SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Brown Suzanne J.) "

Sökning: WFRF:(Brown Suzanne J.)

  • Resultat 41-43 av 43
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
41.
  • Pettersson-Kymmer, Ulrika, et al. (författare)
  • HLA and KIR Associations of Cervical Neoplasia
  • 2018
  • Ingår i: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 218:12, s. 2006-2015
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognised by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk.Methods: Here, we used HLA and KIR dosages imputed from SNP genotype data from 2,143 cervical neoplasia cases and 13,858 healthy controls of European decent.Results: Four novel HLA alleles were identified in association with cervical neoplasia: HLA-DRB3*9901 (OR=1.24, P=2.49×10-9), HLA-DRB5*0101 (OR=1.29, P=2.26×10-8), HLA-DRB5*9901 (OR=0.77, P=1.90×10-9) and HLA-DRB3*0301 (OR=0.63, P=4.06×10-5), due to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles. We also found homozygosity of HLA-C1 group alleles is a protective factor for HPV16-related cervical neoplasia (C1/C1, OR=0.79, P=0.005). This protective association was restricted to carriers of either KIR2DL2 (OR=0.67, P=0.00045) or KIR2DS2 (OR=0.69, P=0.0006).Conclusions: Our findings suggest that HLA-C1 group alleles play a role in protecting against HPV16-related cervical neoplasia, mainly through a KIR-mediated mechanism.
  •  
42.
  • Scott, James S., et al. (författare)
  • Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists
  • 2014
  • Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society. - 0022-2623 .- 1520-4804. ; 57:21, s. 8984-8998
  • Tidskriftsartikel (refereegranskat)abstract
    • Agonism of GPR119 is viewed as a potential therapeutic approach for the treatment of type II diabetes and other elements of metabolic syndrome. During progression of a previously disclosed candidate 1 through mice toxicity studies, we observed tonic-clonic convulsions in several mice at high doses. An in vitro hippocampal brain slice assay was used to assess the seizure liability of subsequent compounds, leading to the identification of an aryl sulfone as a replacement for the 3-cyano pyridyl group. Subsequent optimization to improve the overall profile, specifically with regard to hERG activity, led to alkyl sulfone 16. This compound did not cause tonic-clonic convulsions in mice, had a good pharmacokinetic profile, and displayed in vivo efficacy in murine models. Importantly, it was shown to be effective in wild-type (WT) but not GPR119 knockout (KO) animals, consistent with the pharmacology observed being due to agonism of GPR119.
  •  
43.
  • Zhou, Junhua, et al. (författare)
  • Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause
  • 2021
  • Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:9, s. 1360-1372
  • Tidskriftsartikel (refereegranskat)abstract
    • Sequence analysis identifies gain-of-function somatic mutations in GNA11 or GNAQ in CTNNB1-mutant aldosterone-producing adenomas. Most patients with these mutations presented during puberty, pregnancy or menopause, with elevated LHCGR expression. Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for codriver mutations in APAs. Here we identified gain-of-function mutations in both CTNNB1 and GNA11 by whole-exome sequencing of 3/41 APAs. Further sequencing of known CTNNB1-mutant APAs led to a total of 16 of 27 (59%) with a somatic p.Gln209His, p.Gln209Pro or p.Gln209Leu mutation of GNA11 or GNAQ. Solitary GNA11 mutations were found in hyperplastic zona glomerulosa adjacent to double-mutant APAs. Nine of ten patients in our UK/Irish cohort presented in puberty, pregnancy or menopause. Among multiple transcripts upregulated more than tenfold in double-mutant APAs was LHCGR, the receptor for luteinizing or pregnancy hormone (human chorionic gonadotropin). Transfections of adrenocortical cells demonstrated additive effects of GNA11 and CTNNB1 mutations on aldosterone secretion and expression of genes upregulated in double-mutant APAs. In adrenal cortex, GNA11/Q mutations appear clinically silent without a codriver mutation of CTNNB1.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 41-43 av 43
Typ av publikation
tidskriftsartikel (38)
konferensbidrag (4)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (42)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Garland, Suzanne M. (8)
Cooper, Cyrus (7)
Dillner, Joakim (7)
Brown, Darron R. (7)
Kjaer, Susanne K. (7)
Sigurdsson, Kristjan (7)
visa fler...
Hernandez-Avila, Mau ... (7)
Wheeler, Cosette M. (7)
Perez, Gonzalo (7)
Koutsky, Laura A. (7)
Tay, Eng Hseon (7)
Ault, Kevin A. (7)
Leodolter, Sepp (7)
Tang, Grace W. K. (7)
Ferris, Daron G. (7)
Paavonen, Jorma (7)
Steben, Marc (7)
Joura, Elmar A. (7)
Majewski, Slawomir (7)
Munoz, Nubia (7)
Myers, Evan R. (7)
Villa, Luisa L. (7)
Larsson, Anders (6)
Hankey, Graeme J. (6)
Weiderpass, Elisabet ... (6)
Bensenor, Isabela M. (6)
Dandona, Lalit (6)
Dandona, Rakhi (6)
Geleijnse, Johanna M ... (6)
Jonas, Jost B. (6)
Kokubo, Yoshihiro (6)
Lopez, Alan D. (6)
Lotufo, Paulo A. (6)
Malekzadeh, Reza (6)
Miller, Ted R. (6)
Mokdad, Ali H. (6)
Sepanlou, Sadaf G. (6)
Thorne-Lyman, Andrew ... (6)
Vollset, Stein Emil (6)
Werdecker, Andrea (6)
Yonemoto, Naohiro (6)
Murray, Christopher ... (6)
Moradi-Lakeh, Maziar (6)
Dharmaratne, Samath ... (6)
Goto, Atsushi (6)
Pourmalek, Farshad (6)
Santos, Itamar S. (6)
Abu-Raddad, Laith J. (6)
Iversen, Ole-Erik (6)
Garcia, Patricia (6)
visa färre...
Lärosäte
Lunds universitet (22)
Göteborgs universitet (12)
Uppsala universitet (8)
Karolinska Institutet (8)
Umeå universitet (5)
Stockholms universitet (3)
visa fler...
Mittuniversitetet (2)
Kungliga Tekniska Högskolan (1)
Högskolan i Gävle (1)
Högskolan Väst (1)
Chalmers tekniska högskola (1)
RISE (1)
visa färre...
Språk
Engelska (43)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (33)
Naturvetenskap (6)
Samhällsvetenskap (3)
Teknik (1)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy