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Sökning: WFRF:(Dahlen B.)

  • Resultat 181-190 av 278
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181.
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182.
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183.
  • Bergenholtz, Gunnar, 1939, et al. (författare)
  • Sveriges ledande position inom odontologisk forskning hotas
  • 2003
  • Ingår i: Tandläkartidn. ; 9, s. 60-61
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Nationella samordningsgruppens aktiviteter syftar till att: - identifiera forskningsmiljöer som kan stärkas genom nationell koordinering - sammanföra yngre forskare från olika forskningsmiljöer - sammanföra etablerade forskare men yngre forskare - stimulera till forskningssamarbete på ett nationellt plan
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184.
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185.
  • Blidberg, K, et al. (författare)
  • Chemokine release by neutrophils in chronic obstructive pulmonary disease
  • 2012
  • Ingår i: Innate immunity. - : SAGE Publications. - 1753-4267 .- 1753-4259. ; 18:3, s. 503-510
  • Tidskriftsartikel (refereegranskat)abstract
    • Neutrophils are among the first cells to arrive at the site of injury. Chemokines secreted by neutrophils affect the migration of both neutrophils and other inflammatory cells, such as monocytes. It has been reported that LPS-induced release of IL-8 (CXCL-8) by neutrophils is amplified by neutrophil-derived TNF-α. We hypothesize that chemokine release by neutrophils is altered in chronic obstructive pulmonary disease (COPD) compared with healthy controls and that TNF-α may be involved in this alteration. Peripheral blood neutrophils isolated from smokers with COPD ( n = 12), smokers without COPD ( n = 12) and healthy, non-smokers ( n = 12) were stimulated with LPS, TNF-α or organic dust. Anti-TNF-α Ab (infliximab) was used to study the effect of neutrophil-derived TNF-α. Release of CXCL-8, macrophage inflammatory protein-1 α (MIP-1α, CCL-3), monocyte chemotactic protein-1 (MCP-1, CCL-2) and TNF-α was measured. Neutrophils spontaneously released CXCL-8, CCL-2 and CCL-3. Inhibition of TNF-α reduced the spontaneous release of CXCL-8 and CCL-3. Stimulation with LPS and organic dust increased the release of CXCL-8 and CCL-3 (but not CCL-2) which was reduced by inhibition of TNF-α. In the COPD group, inhibition of TNF-α failed to inhibit the release of LPS-induced CXCL-8. The role of neutrophils as cytokine and chemokine producers was confirmed. Neutrophil-derived TNF-α contributed to the release of chemokines after stimulation with LPS and organic dust, as the response was inhibited by infliximab. In the COPD group, infliximab did not significantly inhibit the release of CXCL-8, suggesting that the role of TNF-α is altered in COPD.
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186.
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187.
  • Bood, Mattias, et al. (författare)
  • Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
  • 2018
  • Ingår i: Chemical Science. - : Royal Society of Chemistry (RSC). - 2041-6520 .- 2041-6539. ; 9:14, s. 3494-3502
  • Tidskriftsartikel (refereegranskat)abstract
    • Emissive base analogs are powerful tools for probing nucleic acids at the molecular level. Herein we describe the development and thorough characterization of pentacyclic adenine (pA), a versatile base analog with exceptional fluorescence properties. When incorporated into DNA, pA pairs selectively with thymine without perturbing the B-form structure and is among the brightest nucleobase analogs reported so far. Together with the recently established base analog acceptor qAnitro, pA allows accurate distance and orientation determination via Forster resonance energy transfer (FRET) measurements. The high brightness at emission wavelengths above 400 nm also makes it suitable for fluorescence microscopy, as demonstrated by imaging of single liposomal constructs coated with cholesterolanchored pA-dsDNA, using total internal reflection fluorescence microscopy. Finally, pA is also highly promising for two-photon excitation at 780 nm, with a brightness (5.3 GM) that is unprecedented for a base analog.
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  • Resultat 181-190 av 278
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tidskriftsartikel (187)
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Dahlen, B (184)
Dahlen, SE (120)
Djukanovic, R (48)
Chung, KF (33)
Sterk, PJ (32)
Chanez, P (30)
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Larsson, K (22)
Corfield, J (22)
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Adcock, IM (21)
Bel, EH (21)
De Meulder, B (20)
Singer, F (20)
Hedlin, G (20)
Fowler, SJ (20)
Sousa, AR (19)
Kull, I (19)
Auffray, C (18)
Bush, A (18)
Roberts, G (18)
Sandstrom, T (18)
Kuna, P (18)
Hashimoto, S (17)
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Dahlen, S (14)
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