| 11. |
- Bejerot, Susanne, 1955-, et al.
(författare)
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Evidence-Based Brief Obsessive-Compulsive Scale
- 2017
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Ingår i: Journal of Central Nervous System Disease. - : Sage Publications. - 1179-5735. ; 9
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Bejerot, Susanne, 1955-, et al.
(författare)
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The Brief Obsessive-Compulsive Scale (BOCS) : a self-report scale for OCD and obsessive-compulsive related disorders
- 2014
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Ingår i: Nordic Journal of Psychiatry. - : Informa Healthcare. - 0803-9488 .- 1502-4725. ; 68:8, s. 549-559
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Tidskriftsartikel (refereegranskat)abstract
- Background: The Brief Obsessive Compulsive Scale (BOCS), derived from the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the children's version (CY-BOCS), is a short self-report tool used to aid in the assessment of obsessive-compulsive symptoms and diagnosis of obsessive-compulsive disorder (OCD). It is widely used throughout child, adolescent and adult psychiatry settings in Sweden but has not been validated up to date.Aim: The aim of the current study was to examine the psychometric properties of the BOCS amongst a psychiatric outpatient population.Method: The BOCS consists of a 15-item Symptom Checklist including three items (hoarding, dysmorphophobia and self-harm) related to the DSM-5 category "Obsessive-compulsive related disorders", accompanied by a single six-item Severity Scale for obsessions and compulsions combined. It encompasses the revisions made in the Y-BOCS-II severity scale by including obsessive-compulsive free intervals, extent of avoidance and excluding the resistance item. 402 adult psychiatric outpatients with OCD, attention-deficit/hyperactivity disorder, autism spectrum disorder and other psychiatric disorders completed the BOCS.Results: Principal component factor analysis produced five subscales titled "Symmetry", "Forbidden thoughts", "Contamination", "Magical thoughts" and "Dysmorphic thoughts". The OCD group scored higher than the other diagnostic groups in all subscales (P < 0.001). Sensitivities, specificities and internal consistency for both the Symptom Checklist and the Severity Scale emerged high (Symptom Checklist: sensitivity = 85%, specificities = 62-70% Cronbach's alpha = 0.81; Severity Scale: sensitivity = 72%, specificities = 75-84%, Cronbach's alpha = 0.94).Conclusions: The BOCS has the ability to discriminate OCD from other non-OCD related psychiatric disorders. The current study provides strong support for the utility of the BOCS in the assessment of obsessive-compulsive symptoms in clinical psychiatry.
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| 13. |
- Bjerkenstedt, Lars, et al.
(författare)
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Support for limited brain availability of tyrosine in patients with schizophrenia
- 2006
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Ingår i: International Journal of Neuropsychopharmacology. - 1461-1457 .- 1469-5111. ; 9, s. 247-255
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Tidskriftsartikel (refereegranskat)abstract
- Several mechanisms have been suggested to account for altered dopaminergic neurotransmission in schizophrenia. The brain is the only organ for which amino-acid transport is limited and competition for transport over the blood-brain barrier (BBB) occurs at physiological plasma concentrations. One line of research suggests that patients with schizophrenia have altered brain levels of the essential amino acid tyrosine, the precursor for the synthesis of dopamine. The most common hypothesis is that less tyrosine is available because of competition with elevated levels of other amino acids. By consequence, the synthesis of dopamine in the brain will decrease. In contrast, another line of evidence suggests a change in the affinity for one of the transport proteins. A limitation of this research has been that the systems for amino-acid transport across the BBB have not been fully characterized at a molecular or functional level. The L system is the major system for transport of tyrosine across cell membranes including the BBB. The A system is also involved in this transport. Earlier in-vitro studies using fibroblasts have demonstrated a normal L system in schizophrenia but nevertheless reduced tyrosine transport. The combination of molecular research, fibroblast techniques, and brain imaging provides a new basis for clinical research on the role of amino-acid membrane transport in schizophrenia.
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| 14. |
- Boden, Robert, et al.
(författare)
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A comparison of cardiovascular risk factors for ten antipsychotic drugs in clinical practice
- 2013
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Ingår i: Neuropsychiatric Disease and Treatment. - 1176-6328 .- 1178-2021. ; 9, s. 371-377
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Tidskriftsartikel (refereegranskat)abstract
- It is well known that abdominal obesity, dyslipidemia, and insulin resistance are highly prevalent in patients receiving maintenance treatment with antipsychotics, but there is limited knowledge about the association between cardiovascular risk factors and treatment with antipsychotic drugs. In this naturalistic study we investigated a sample of 809 antipsychotic-treated patients from Swedish psychosis outpatient teams. Cardiovascular risk factors (eg, metabolic syndrome, homeostasis model assessment of insulin resistance, and low-density lipoprotein values) were measured, and their associations to current antipsychotic pharmacotherapy were studied. Ten antipsychotic drugs were compared in a stepwise logistic regression model. For the patients, the presence of the components of metabolic syndrome ranged from 35% for hyperglycemia to 64% for elevated waist circumference. Hypertriglyceridemia was associated with clozapine (odds ratio [OR] = 1.81, 95% confidence interval [CI] 1.08-3.04), reduced high-density lipoprotein with both clozapine and olanzapine (OR = 1.73, 95% CI 1.01-2.97; and OR = 2.03, 95% CI 1.32-3.13), hypertension with perphenazine (OR = 2.00, 95% CI 1.21-3.59), and hyperglycemia inversely with ziprasidone (OR = 0.21, 95% CI 0.05-0.89) and positively with haloperidol (OR = 2.02, 95% CI 1.18-3.48). There were no significant relationships between any of the antipsychotic drugs and increased waist circumference, homeostasis model assessment of insulin resistance, or low-density lipoprotein levels. In conclusion, treatment with antipsychotic drugs is differentially associated with cardiovascular risk factors, even after adjusting for waist circumference, sex, age, and smoking.
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| 15. |
- Carlsson, Fredrik, et al.
(författare)
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Effect of heat on interspecific competition in saprotrophic wood fungi
- 2014
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Ingår i: Fungal ecology. - : Elsevier BV. - 1754-5048 .- 1878-0083. ; 11, s. 100-106
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Tidskriftsartikel (refereegranskat)abstract
- Some boreal wood fungi that are associated with forest fire or open dry habitats have an increased resistance to heat in comparison to species associated with a less specific distribution or species found in mesic forests. We hypothesize that extreme temperature-stress experienced during fires will favor species adapted to heat and, ultimately, the composition of species inhabiting logs in such habitats will change. Competitiveness after temperature stress was examined in three fire-associated species – Dichomitus squalens, Gloeophyllum sepiarium and Phlebiopsis gigantea – and three non fire-associated species – Ischnoderma benzoinum, Phellinus pini and Fomitopsis pinicola. There was a difference between the fire-associated species and the non fire-associated species with respect to competitive strength after heat stress. All fire-associated species had an advantage after heat treatment, colonizing a larger volume of wood than any non-fire-associated competitor. Our findings suggest that increased heat tolerance of mycelia can exert a competitive balance shift after forest fire. It shows that a system governed by forest fire will be dominance controlled under certain conditions. Furthermore, from a management perspective, during a prescribed burning, certain species already present in the ecosystem will be favored if the fire is not allowed to totally consume the substrates.
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| 16. |
- Carlsson, Fredrik, 1974-, et al.
(författare)
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Increased CO2 evolution caused by heat treatment in wood-decaying fungi
- 2017
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Ingår i: Mycological progress. - : Springer Science and Business Media LLC. - 1617-416X .- 1861-8952. ; 16:5, s. 513-519
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Tidskriftsartikel (refereegranskat)abstract
- Wood-decaying fungi are regarded as the main decomposers of woody debris in boreal forests. Given that fungal respiration makes a significant contribution to terrestrial carbon flows, it is important to understand how the wood-decaying fungal metabolism is regulated in relation to different environmental conditions and disturbances. In the present study, we investigated the effect of temperature stress on wood decomposition rate in 18 species of wood-decaying fungi, representing a broad range of species-habitat associations. Heat shock duration and temperature were calibrated to match the conditions of a forest fire. We found a general increase in fungal decay rate after heat shock; the response was more pronounced in species associated with fire-prone forests. The underlying mechanism is unclear, but possibly relates to an up-regulation at the cellular level in response to heat shock. Our results show that the decomposition rate of dead wood can be strongly affected by environmental triggers.
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| 17. |
- Carlsson, Fredrik, 1974-, et al.
(författare)
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Increased decomposition, triggered by heat shock found in wood fungi
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Wood fungi can be extremely heat resilient: several studies have shown that species can survive highly elevated temperatures relative to their growth optima. In this study we examine the effect of heat shock on subsequent decomposition rates. Sixteen species of wood fungi were tested over a period of 17 weeks. All strains were inoculated on to sterilized pine wood cylinders, placed in small bio chambers and tested twiice a week for CO2 accumulation. After 8 weeks all species were subjected to heat shock. We found that this triggered an increased decomposition rate in all species, this increase peaked 6 weeks after the shock. the peak was higher in wood fungi species that are associated with forest fires compared to specoes with no such association.
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| 18. |
- Carlsson, Fredrik, 1974-, et al.
(författare)
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Increased heat resistance in mycelia from wood fungi prevalent in forests characterized by fire : a possible adaptation to forest fire.
- 2012
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Ingår i: Fungal Biology. - : Elsevier BV. - 1878-6146 .- 1878-6162. ; 116:10, s. 1025-1031
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Tidskriftsartikel (refereegranskat)abstract
- AbstractForest fire has for a long time been the major stand replacing/modifying disturbance in boreal forests. For organisms to adopt to this phenomenon different strategies for protective measurements has evolved. This study focuses on the organism group of wood fungi, and one of several possibilities for adaptation to forest fire - increased heat resistance in the mycelia. 16 species of wood fungi where selected and sorted a priori according to their prevalence for fire affected substrate. These were isolated and re-inoculated on pine wood before testing. Experiments where done in a series where the mycelia was exposed to 100, 140, 180, 220°C for 5, 10, 15, 20, 15 min. A very clear difference was found, the group containing species with a prevalence for a fire affected substrate had a much higher survival rate over all combinations of time and temperature compared to species with a more general ecology. This data suggests that increased heat resistance in mycelia could be a possible adaptation to forest fire. This in turn has major impacts on the ecology and population dynamics of wood fungi. An increase in temperature could shift the population structure in a log, allowing minor non fruiting mycelia content to expand on the expense of earlier dominant colonizers. Furthermore this study has implications on how to control prescribed restoration burning events. When burning areas where the dead wood content is dominated by early decay stages, loss of species can be avoided by proper management.
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| 19. |
- Carlsson, Fredrik, 1974-
(författare)
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Wood Fungi and Forest Fire
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Forest fires have been the major stand-replacing/modifying disturbance in boreal forests. To adapt to fire disturbance, different strategies have evolved. This thesis focuses on wood fungi, and the effect of forest fire on this organism group. In many ways it is a study on adaptation to forest fire, in concurrence with adaptation to dry open habitats. In Paper I we study increased heat resistance in mycelia from species prevalent in fire prone environments. Fungi were cultivated on fresh wood and exposed to different temperatures. Species prevalent in fire affected habitats had a much higher survival rate over all combinations of time and temperature compared to species associated with other environments. Based on this results the competitiveness was tested after temperature stress (paper II), three fire associated species, were tested against three non fire associated species. All fire associated species had a clear advantage after heat treatment, conquering a larger volume of wood than its competitor. In paper III we studied the effect of heat shock on decomposition rate, 18 species was tested. Species were cultivated and monitored for CO2 accumulation for 8 weeks and then heat shocked. All species including non fire associated species seemed to up-regulate decomposition after heat shock, this response was more pronounced in fire associated species. To look at the possible effect of forest fire on population structure (Paper IV), we developed 29 SNP/INDELs for Phlebiopsis. gigantea. We amplified the marker containing fragments in 132 individuals of P. gigantea in 6 populations, 3 which were found in areas affected by forest fire and 3 in unaffected areas. We found no genetic structure in accordance to forest fire. However we detected geographic structure, which stands in contrast to earlier studies. This might be due to the method, using SNP´s and number of individuals in the study. Finally we collected cross-sections of decayed logs to evaluate the number of fungal species domains that are likely to be hit when drilling a saw-dust sample in a log. We used these estimates to simulate how many species that will be found by a certain number of samples. We found that in 99% of the
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| 20. |
- Darvishi, Mehdi, et al.
(författare)
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InSAR-based Ground Motion Service of Sweden: evaluation and benefit analysis of a nationwide InSAR service
- 2022
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Konferensbidrag (refereegranskat)abstract
- Space-geodetic techniques such as Global Navigation Satellite Systems (GNSS) and Syntenic Aperture Radar interferometry (InSAR) are powerful tools to measure and monitor ground surface motion. InSAR has widely been used for the detection and quantification of slow mass movements over the past three decades mainly at the local and regional scales. The high performance and millimeter-level measurement accuracy of radar satellite to provide a dense deformation map at different spatial and temporal resolutions are the key factors to think of using SAR data and InSAR technique as an efficient tool for geohazards motoring system at the nationwide scale.Sweden has recently joined to the countries having InSAR Ground Motion Service (GMS) at a nationwide scale. The InSAR service of Sweden, which will soon be freely available for users, provides the displacement time-series of measurement points for the entire country. The Swedish GMS project was started last year and is an ongoing collaboration between the Geological Survey of Norway (NGU) and several Swedish organizations (led by the Swedish National Space Agency (SNSA)). The InSAR-based GMS of Sweden has been generated by NGU using Sentinel-1 data (2015–2020) and the Persistent Scatterer Interferometry (PSI) technique. The web-based GMS of Sweden consists of ~1,5 billion time-series measurement points obtained from both descending and ascending satellite orbital modes.Currently, the Swedish GMS is under evaluation and validation phase and the given plan has been designed to assess the quality or validate the GMS products. We plan to conduct the data validation through two main phases: 1) a cross-comparison between InSAR measurement points and ancillary data such as GNSS, Corner Reflectors (CR), Electronic Corner Reflectors (ECR) and leveling data, and 2) assessment of tropospheric and ionospheric effects on InSAR measurement points. Specifically, we will evaluate different approaches and data for the InSAR tropospheric corrections, such as Very-Long-Baseline Interferometry (VLBI), Water Vapour Radiometry (WVR), and GNSS data at the Onsala Space Observatory (OSO).In the first phase of validation, leveling data collected in Gothenburg and Stockholm cities, mainly over the residential areas and public transport infrastructures compared to the corresponding InSAR measurements points (vertically converted) for a five-year period. The initial results present a high correlation between two sets of the vertical displacements. The same procedure will be performed for the Kiruna city where the mining activities resulted in adrastic urban land subsidence. Since the CRs and ECRs have recently been installed in different parts of Sweden, we do not have them as PS points in the current version of the GMS. Therefore, those CR-based measurement points will be used in future accuracy assessments. In the second phase, we investigated the effects of phase delay induced by troposphere on displacement time-series using two approaches, i.e., time-space filtering and using external data (e.g., atmospheric reanalysis data, GNSS, VLBI and Water Vapor Radiometer (WVR)). Recently, European GMS (EGMS) has been released and the Ortho displacement map is now available for users freely. We also evaluated and compared the EGMS-Ortho displacement map with our independent InSAR processing and GNSS data over the Kiruna.As the InSAR-based GMS can be used to monitor and identify the potential risk of geo-related hazards in Sweden, the society will directly benefit from the outcomes of this project. This open access product will help the stakeholders with decision support for prioritization of risk-reducing measures, and identification of the need for further investigations for areas in danger. The service could also assist municipalities and county administrative boards to have an update information regarding urban areas which are more prone to land subsidence and disruption urban infrastructure.
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