| 11. |
- Fensch, Jeremy, et al.
(författare)
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Massive star cluster formation and evolution in tidal dwarf galaxies
- 2019
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massiveclusters with similar masses as globular clusters and may hold the key to understanding their formation.Aims.We study star cluster formation in a tidal debris - including the vicinity of three tidal dwarf galaxies - in a massive gas dominatedcollisional ring around NGC 5291. These dwarfs have physical parameters which differ significantly from local starbursting dwarfs.They are gas-rich, highly turbulent, have a gas metallicity already enriched up to half-solar, and are expected to be free of dark matter.The aim is to study massive star cluster formation in this as yet unexplored type of environment.Methods.We use imaging from theHubble Space Telescopeusing broadband filters covering the wavelength range from the near-ultraviolet to the near-infrared. We determine the masses and ages of the cluster candidates by using the spectral energy distribution-fitting code CIGALE, carefully considering age-extinction degeneracy effects on the estimation of the physical parameters.Results.We find that the tidal dwarf galaxies in the ring of NGC 5291 are forming star clusters with an average efficiency of∼40%,comparable to blue compact dwarf galaxies. We also find massive star clusters for which the photometry suggests that they wereformed at the very birth of the tidal dwarf galaxies and have survived for several hundred million years. Therefore our study showsthat extended tidal dwarf galaxies and compact clusters may be formed simultaneously. In the specific case observed here, the youngstar clusters are not massive enough to survive for a Hubble time. However one may speculate that similar objects at higher redshift,with higher star formation rate, might form some of the long lived globular clusters.Key words.galaxies: dwarf, galaxies: star clusters: general, galaxies: irregular, galaxies: star formation, galaxies: stellar content,galaxies: interactions
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| 12. |
- Fensch, Jeremy, et al.
(författare)
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Massive star cluster formation and evolution in tidal dwarf galaxies
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 628
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Tidskriftsartikel (refereegranskat)abstract
- Context. The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massive clusters with similar masses as globular clusters and may hold the key to understanding their formation. Aims. We study star cluster formation in a tidal debris, including the vicinity of three tidal dwarf galaxies, in a massive gas-dominated collisional ring around NGC 5291. These dwarfs have physical parameters that differ significantly from local starbursting dwarfs. They are gas rich, highly turbulent, their gas metallicity is already enriched up to half solar values, and they are expected to be free of dark matter. The aim is to study massive star cluster formation in this as yet unexplored type of environment. Methods. We used imaging from the Hubble Space Telescope using broadband filters that cover the wavelength range from the near-ultraviolet to the near-infrared. We determined the masses and ages of the cluster candidates by using the spectral energy distribution-fitting code CIGALE. We considered age-extinction degeneracy effects on the estimation of the physical parameters. Results. We find that the tidal dwarf galaxies in the ring of NGC 5291 are forming star clusters with an average efficiency of ∼40%, which is similar to blue compact dwarf galaxies. We also find massive star clusters for which the photometry suggests that they were formed at the very birth of the tidal dwarf galaxies. These clusters have survived for several hundred million years. Therefore our study shows that extended tidal dwarf galaxies and compact clusters may be formed simultaneously. In the specific case observed here, the young star clusters are not massive enough to survive for a Hubble time. However, it may be speculated that similar objects at higher redshift, with a higher star formation rate, might form some of the long-lived globular clusters.
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| 13. |
- Goetz, Charlotte, et al.
(författare)
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The plasma environment of comet 67P/Churyumov-Gerasimenko
- 2022
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Ingår i: Space Science Reviews. - : Springer. - 0038-6308 .- 1572-9672. ; 218:8
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Forskningsöversikt (refereegranskat)abstract
- The environment of a comet is a fascinating and unique laboratory to study plasma processes and the formation of structures such as shocks and discontinuities from electron scales to ion scales and above. The European Space Agency's Rosetta mission collected data for more than two years, from the rendezvous with comet 67P/Churyumov-Gerasimenko in August 2014 until the final touch-down of the spacecraft end of September 2016. This escort phase spanned a large arc of the comet's orbit around the Sun, including its perihelion and corresponding to heliocentric distances between 3.8 AU and 1.24 AU. The length of the active mission together with this span in heliocentric and cometocentric distances make the Rosetta data set unique and much richer than sets obtained with previous cometary probes. Here, we review the results from the Rosetta mission that pertain to the plasma environment. We detail all known sources and losses of the plasma and typical processes within it. The findings from in-situ plasma measurements are complemented by remote observations of emissions from the plasma. Overviews of the methods and instruments used in the study are given as well as a short review of the Rosetta mission. The long duration of the Rosetta mission provides the opportunity to better understand how the importance of these processes changes depending on parameters like the outgassing rate and the solar wind conditions. We discuss how the shape and existence of large scale structures depend on these parameters and how the plasma within different regions of the plasma environment can be characterised. We end with a non-exhaustive list of still open questions, as well as suggestions on how to answer them in the future.
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| 14. |
- Gunell, Herbert, et al.
(författare)
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Ion acoustic waves near a comet nucleus : Rosetta observations at comet 67P/Churyumov-Gerasimenko
- 2021
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 39:1, s. 53-68
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Tidskriftsartikel (refereegranskat)abstract
- Ion acoustic waves were observed between 15 and 30 km from the centre of comet 67P/Churyumov-Gerasimenko by the Rosetta spacecraft during its close flyby on 28 March 2015. There are two electron populations: one cold at k(B)T(e) approximate to 0.2 eV and one warm at k(B)T(e) approximate to 2 eV. The ions are dominated by a cold (a few hundredths of electronvolt) distribution of water group ions with a bulk speed of (3-3.7) km s(-1). A warm k(B)T(e) approximate to 6 eV ion population, which also is present, has no influence on the ion acoustic waves due to its low density of only 0.25 % of the plasma density. Near closest approach the propagation direction was within 50 degrees from the direction of the bulk velocity. The waves, which in the plasma frame appear below the ion plasma frequency f(pi) approximate to 2 kHz, are Doppler-shifted to the spacecraft frame where they cover a frequency range up to approximately 4 kHz. The waves are detected in a region of space where the magnetic field is piled up and draped around the inner part of the ionised coma. Estimates of the current associated with the magnetic field gradient as observed by Rosetta are used as input to calculations of dispersion relations for current-driven ion acoustic waves, using kinetic theory. Agreement between theory and observations is obtained for electron and ion distributions with the properties described above. The wave power decreases over cometocentric distances from 24 to 30 km. The main difference between the plasma at closest approach and in the region where the waves are decaying is the absence of a significant current in the latter. Wave observations and theory combined supplement the particle measurements that are difficult at low energies and complicated by spacecraft charging.
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| 15. |
- Göransson, Melker, 1974, et al.
(författare)
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP β-mediated interleukin 6 expression
- 2005
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 115:4, s. 556-560
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Tidskriftsartikel (refereegranskat)abstract
- The myxoid/round cell liposarcoma oncogene FUS-DDIT3 is the result of a translocation derived gene fusion between the splicing factor FUS and DDIT3. In order to investigate the downstream targets of DDIT3, and the transforming effects of the FUS-DDIT3 fusion protein, we have introduced DDIT3-GFP and FUS-DDIT3-GFP constructs into a human flbrosarcoma cell line. The gene expression profiles of stable transfectants were compared to the original fibrosarcoma cell line by microarray analysis. We here report that the NFκB and C/EBP β controlled gene IL6 is upregulated in DDIT3- and FUS-DDIT3-expressing fibrosarcoma cell lines and in myxoid liposarcoma cell lines. Strong expression of the tumor associated multifunctional cytokine interleukin 6 was confirmed both at mRNA and protein level. Knockdown experiments using siRNA against CEBPB transcripts showed that the effect of FUS-DDIT3 on IL6 expression is C/EBP β dependent. Chromatin immunoprecipitation revealed direct interaction between the IL6 promoter and the C/EBP β protein. In addition, the effect of DDIT3 and FUS-DDIT3 on the expression of other acute phase genes was examined using real-time PCR. We demonstrate for the first time that DDIT3 and FUS-DDIT3 show opposite transcriptional regulation of IL8 and suggest that FUS-DDIT3 may affect the synergistic activation of promoters regulated by C/EBP β and NFκB.
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| 16. |
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| 17. |
- Johansson, Fredrik Leffe, 1988-, et al.
(författare)
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Plasma densitites, flow and Solar EUV flux at comet 67P : A cross-calibration approach
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746.
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Tidskriftsartikel (refereegranskat)abstract
- Context.During its two year mission at comet 67P, Rosetta nearly continuously monitored the inner coma plasma environment forgas production rates varying over three orders of magnitude, at distances to the nucleus from a few to a few hundred km. To achievethe best possible measurements, cross-calibration of the plasma instruments is needed.Aims.To provide a consistent plasma density data set for the full mission, in the process providing a statistical characterisation of theplasma processes in the inner coma and their evolution.Methods.We construct physical models for two different methods to cross-calibrate the spacecraft potential and the ion current asmeasured by the Rosetta Langmuir Probes (LAP) to the electron density as measured by the Mutual Impedance Probe (MIP). We alsodescribe the methods used to estimate spacecraft potential, and validate the results with the Ion Composition Analyser, (ICA).Results.We retrieve a continuous plasma density dataset for the entire cometary mission with a much improved dynamical rangecompared to any plasma instrument alone and, at times, improve the temporal resolution from 0.24-0.74 Hz to 57.8 Hz. The physicalmodel also yields, at 3 hour time resolution, ion flow speeds as well as a proxy for the solar EUV flux from the photoemission fromthe Langmuir Probes.Conclusions.We report on two independent estimates of the ion flow speed which are consistent with the bulk H2O+ion velocitiesas measured by ICA. We find the ion flow to be much faster than the neutral gas, lending further evidence that the ions are mostlycollisionally decoupled from the neutrals in the coma. Also, the measured EUV flux is perfectly consistent with independent measurements previously published in Johansson et al. (2017) and lends support for the conclusions drawn therein regarding an attenuationof solar EUV from a distant nanograin dust population between the comet and the Sun, when the comet activity was high. The newdensity dataset is consistent with the existing MIP density dataset, but facilitates plasma analysis at much shorter timescales, with anincreased temporal resolution of a factor of (up to) 240 and covers also long time periods where densities were too low to be measuredby MIP.
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| 18. |
- Kappos, Ludwig, et al.
(författare)
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Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
- 2018
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 391, s. 1263-1273
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Tidskriftsartikel (refereegranskat)abstract
- © 2018 Elsevier Ltd Background: No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor 1,5 modulator, on disability progression in patients with SPMS. Methods: This event-driven and exposure-driven, double-blind, phase 3 trial was done at 292 hospital clinics and specialised multiple sclerosis centres in 31 countries. Using interactive response technology to assign numbers linked to treatme nt arms, patients (age 18–60 years) with SPMS and an Expanded Disability Status Scale score of 3·0–6·5 were randomly assigned (2:1) to once daily oral siponimod 2 mg or placebo for up to 3 years or until the occurrence of a prespecified number of confirmed disability progression (CDP) events. The primary endpoint was time to 3-month CDP. Efficacy was assessed for the full analysis set (ie, all randomly assigned and treated patients); safety was assessed for the safety set. This trial is registered with ClinicalTrials.gov, number NCT01665144. Findings: 1651 patients were randomly assigned between Feb 5, 2013, and June 2, 2015 (1105 to the siponimod group, and 546 to the placebo group). One patient did not sign the consent form, and five patients did not receive study drug, all of whom were in the siponimod group. 1645 patients were included in the analyses (1099 in the siponimod group and 546 in the placebo). At baseline, the mean time since first multiple sclerosis symptoms was 16·8 years (SD 8·3), and the mean time since conversion to SPMS was 3·8 years (SD 3·5); 1055 (64%) patients had not relapsed in the previous 2 years, and 918 (56%) of 1651 needed walking assistance. 903 (82%) patients receiving siponimod and 424 (78%) patients receiving placebo completed the study. 288 (26%) of 1096 patients receiving siponimod and 173 (32%) of 545 patients receiving placebo had 3-month CDP (hazard ratio 0·79, 95% CI 0·65–0·95; relative risk reduction 21%; p=0·013). Adverse events occurred in 975 (89%) of 1099 patients receiving siponimod versus 445 (82%) of 546 patients receiving placebo; serious adverse events were reported for 197 (18%) patients in the siponimod group versus 83 (15%) patients in the placebo group. Lymphopenia, increased liver transaminase concentration, bradycardia and bradyarrhythmia at treatment initiation, macular oedema, hypertension, varicella zoster reactivation, and convulsions occurred more frequently with siponimod than with placebo. Initial dose titration mitigated cardiac first-dose effects. Frequencies of infections, malignancies, and fatalities did not differ between groups. Interpretation: Siponimod reduced the risk of disability progression with a safety profile similar to that of other S1P modulators and is likely to be a useful treatment for SPMS. Funding: Novartis Pharma AG.
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| 19. |
- Loizides, Michael, et al.
(författare)
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Has taxonomic vandalism gone too far? A case study, the rise of the pay-to-publish model and the pitfalls of Morchella systematics
- 2022
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Ingår i: Mycological progress. - : Springer Science and Business Media LLC. - 1617-416X .- 1861-8952. ; 21:1, s. 7-38
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Tidskriftsartikel (refereegranskat)abstract
- The genus Morchella has gone through turbulent taxonomic treatments. Although significant progress in Morchella systematics has been achieved in the past decade, several problems remain unresolved and taxonomy in the genus is still in flux. In late 2019, a paper published in the open-access journal Scientific Reports raised serious concerns about the taxonomic stability of the genus, but also about the future of academic publishing. The paper, entitled “High diversity of Morchella and a novel lineage of the esculenta clade from the north Qinling Mountains revealed by GCPSR-based study” by Phanpadith and colleagues, suffered from gross methodological errors, included false results and artifactual phylogenies, had misapplied citations throughout, and proposed a new species name invalidly. Although the paper was eventually retracted by Scientific Reports in 2021, the fact that such an overtly flawed and scientifically unsound paper was published in a high-ranked Q1 journal raises alarming questions about quality controls and safekeeping procedures in scholarly publishing. Using this paper as a case study, we provide a critical review on the pitfalls of Morchella systematics followed by a series of recommendations for the delimitation of species, description of taxa, and ultimately for a sustainable taxonomy in Morchella. Problems and loopholes in the academic publishing system are also identified and discussed, and additional quality controls in the pre- and post-publication stages are proposed.
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| 20. |
- Markstedt, Elias, 1984, et al.
(författare)
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The subjective meaning of gender: how survey designs affect perceptions of femininity and masculinity
- 2021
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Ingår i: European Journal of Politics and Gender. - : Bristol University Press. - 2515-1088 .- 2515-1096. ; 4:1, s. 51-70
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Tidskriftsartikel (refereegranskat)abstract
- The rationale for this study is that self-categorising rating scales are becoming increasingly popular in large-scale survey research moving beyond binary ways of measuring gender. We are referring here to the use of rating scales that are similar to graded scales capturing left–right or liberal–conservative political ideology, that is, scales that do not include predefinitions of the core concepts (femininity/masculinity, as compared to left/right or liberal/conservative). Yet, previous studies including such non-binary gender measures have paid little attention to potential effects of survey designs. Using an experimental set-up, we are able to show that sequencing of gender measurements influences the answers received. Men were especially affected by our treatments and rated themselves as significantly ‘less masculine’ when prompted to reason about the meaning of gender prior to self-categorisation on scales measuring degrees of femininity and masculinity. Moreover, self-categorising seems to trigger more biological understandings of gender than anticipated in theory.
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