| 681. |
- Molander, Mikael, et al.
(författare)
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p-Mentha-1,3-dien-9-ol: A novel aggregation-sex pheromone for monitoring longhorn beetles (Cerambycidae) in Eurasia and North America
- 2022
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Ingår i: Journal of Applied Entomology. - : Wiley. - 0931-2048 .- 1439-0418. ; 146, s. 1098-1108
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Tidskriftsartikel (refereegranskat)abstract
- Longhorn beetles (Cerambycidae) are a diverse family of beetles that can cause considerable damage as forest pests and vectors of pathogens, as well as being important components of forest food webs and ecosystem functionality. In recent years, numerous cerambycid pheromones have been identified, revealing some broad general patterns in functionality in terms of sex or aggregation-sex pheromones in different subfamilies and different types of compounds characterizing the pheromones of various cerambycid taxa. Here, we describe the identification of the aggregation-sex pheromones of the Eurasian longhorn beetle Aromia moschata moschata (L.) (Cerambycinae; tribe Callichromatini) and the North American species Holopleura marginata LeConte (Cerambycinae; Holopleurini), as part of an ongoing effort to extend the taxonomic coverage of identified cerambycid pheromones and to expand the prospects for cerambycid monitoring into the study of biodiversity and ecosystem services. Both species were found to use the novel pheromone compound p-mentha-1,3-dien-9-ol, which also attracted significant numbers of the longhorn beetle Xestoleptura crassipes (LeConte) (Lepturinae; Lepturini) in trials in California. p-Mentha-1,3-dien-9-ol represents a class of pheromone compounds novel to both tribes (Callichromatini and Holopleurini), further increasing the chemical space of identified pheromones within the subfamily Cerambycinae. This compound is also noteworthy because it represents an entirely different chemical class of pheromones than the monoepoxide (E)-2-cis-6,7-epoxynonenal, previously reported as an aggregation-sex pheromone for the invasive Asian congener Aromia bungii (Faldermann).
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| 682. |
- Molander, Mikael, et al.
(författare)
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The aggregation-sex pheromones of the cerambycid beetles Anaglyptus mysticus and Xylotrechus antilope ssp. antilope: new model species for insect conservation through pheromone-based monitoring
- 2019
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Ingår i: Chemoecology. - : Springer Science and Business Media LLC. - 0937-7409 .- 1423-0445. ; 29, s. 111-124
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Tidskriftsartikel (refereegranskat)abstract
- We studied the pheromone chemistry of the cerambycids Anaglyptus mysticus and Xylotrechus antilope ssp. antilope with the goal of identifying attractants that could be used as tools for pheromone-based monitoring of these two species, which are rare and red-listed in parts of northern Europe. Beetles were reared from naturally colonized branches of hazel (Corylus avellana) or oak (Quercusrobur), respectively, and used for headspace sampling. The extracts of volatiles were analyzed by gas chromatography-mass spectrometry. Males of A. mysticus consistently produced large quantities of (R)-3-hydroxy-2-hexanone and 2-nonanone, minor amounts of 2,3-hexanedione, and trace amounts of six other compounds. The average proportion of 2-nonanone to (R)-3-hydroxy-2-hexanone was 70:100. Males of X. antilope produced large quantities of (S)-2-hydroxy-3-octanone, and minor quantities of 2,3-octanedione. None of these compounds were present in the corresponding extracts of females from either species. The attractiveness of the dominant compounds produced by each species was determined in field bioassays. Lures with racemic 3-hydroxy-2-hexanone and 2-nonanone as single compounds were not attractive to A. mysticus. However, the compounds acted synergistically in blends of 100:100 and 160:100 of 2-nonanone to the hydroxyketone's (R)-enantiomer, but not in a 40:100 blend. Similarly (S)-2-hydroxy-3-octanone and its racemate attracted significantly more X. antilope than controls. Males and females of both species were captured in approximately equal numbers. The aggregation-sex pheromones of A. mysticus and X.antilope have high potential to serve as sensitive and efficient tools for detection and monitoring of local populations, and in studies of the species' ecology and conservation requirements.
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| 683. |
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| 684. |
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| 685. |
- Mosa, Waddah, et al.
(författare)
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Software-supported Hazards Identification for Plug & Produce Systems
- 2024
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Ingår i: Flexible Automation and Intelligent Manufacturing: Establishing Bridges for More Sustainable Manufacturing Systems. - : Springer Nature. - 9783031382406 - 9783031382413 ; , s. 603-610
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Konferensbidrag (refereegranskat)abstract
- This paper presents a model-based safety software that performs Hazard Identification (HI) for Plug&Produce (P&P) systems automatically. P&P systems, inspired by Plug&Play in computers, aim to integrate devices and tools into the manufacturing system with minimum integration efforts and costs. When plugging a new resource, it will exchange all the required information with the manufacturing system and be ready to operate within minutes rather than days or weeks. One of the challenges that face this concept is performing proper risk assessment after each change in the system. Therefore, the risk assessment needs to be automated as much as possible. This paper is about automating one risk assessment step: Hazard Identification. A new safety model is designed to identify hazards. The presented software analyses this model by implementing a novel algorithm that uses lookup tables to cover various possible hazards when resources work together. This software will support the risk reduction team by drastically reducing the time needed for HI and being ready for the next steps in risk analyses. Automating identifying hazards is an essential step towards automating the entire risk assessment process and achieving safe P&P systems.
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| 686. |
- Mu, Xiangkui, 1972-
(författare)
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Clinical application of intensity and energy modulated radiotherapy with photon and electron beams
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In modern, advanced radiotherapy (e.g. intensity modulated photon radiotherapy, IMXT) the delivery time for each fraction becomes prolonged to 10-20 minutes compared with the conventional, commonly 2-5 minutes. The biological effect of this prolongation is not fully known. The large number of beam directions in IMXT commonly leads to a large integral dose in the patient. Electrons would reduce the integral dose but are not suitable for treating deep-seated tumour, due to their limited penetration in tissues. By combining electron and photon beams, the dose distributions may be improved compared with either used alone. One obstacle for using electron beams in clinical routine is that there is no available treatment planning systems that optimise electron beam treatments in a similar way as for IMXT. Protons have an even more pronounced dose fall-off, larger penetration depth and less penumbra widening than electrons and are therefore more suitable for advanced radiotherapy. However, proton facilities optimised for advanced radiotherapy are not commonly available. In some instances electron beams may be an acceptable surrogate. The first part of this study is an experimental in vitro study where the situation in a tumour during fractionated radiotherapy is simulated. The effect of the prolonged fraction time is compared with the predictions by radiobiological models. The second part is a treatment planning study to analyse the mixing of electron and photon beams for at complex target volume in comparison with IMXT. In the next step a research version of an electron beam optimiser was used for the improvement of treatment plans. The aim was to develop a method for translating crude energy and intensity matrices for optimised electrons into a deliverable treatment plan without destroying the dose distribution. In the final part, different methods of treating the spinal canal in medulloblastoma were explored in a treatment planning study that was evaluated with biological models for estimating risks for late radiation effects. The effect on cell survival of prolonging fraction time at conventional doses/fraction is significant in an in vitro system. This effect is underestimated by biological models. Prolonging the fraction time will spare tissues with a fast DNA repair. Thus, there is a risk for sparing tumours. The mixed electron and photon beam technique has the potential to treat deep-seated tumours. Compared with IMXT the number of beams can be reduced and as a consequence, the time for each fraction could be kept shorter. The integral dose in the patient will also be lower. The mixed beam technique could potentially be further improved if automatic optimisation for electrons was available. The results suggest that optimisation and segmentation can be automated, and a deliverable treatment plan can be obtained with simple procedures without destroying the quality of the dose distribution. The integral dose in patients may lead to late radiation side effects. In childhood cancers the risk for development of radiation induced cancers is a reality and the integral dose outside the target volume should be minimised. Based on models for cancer induction, protons show the lowest risk while electrons have some benefit compared with different photon techniques. All methods are able to similarly well treat the target volume.
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| 687. |
- Mu, Xiangkui, et al.
(författare)
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Does electron and proton therapy reduce the risk of radiation induced cancer after spinal irradiation for childhood medulloblastoma? A comparative treatment planning study.
- 2005
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Ingår i: Acta oncologica (Stockholm, Sweden). - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 44:6, s. 554-62
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this treatment planning comparison study was to explore different spinal irradiation techniques with respect to the risk of late side-effects, particularly radiation-induced cancer. The radiotherapy techniques compared were conventional photon therapy, intensity modulated x-ray therapy (IMXT), conventional electron therapy, intensity/energy modulated electron therapy (IMET) and proton therapy (IMPT).CT images for radiotherapy use from five children, median age 8 and diagnosed with medulloblastoma, were selected for this study. Target volumes and organs at risk were defined in 3-D. Treatment plans using conventional photon therapy, IMXT, conventional electron therapy, IMET and IMPT were set up. The probability of normal tissue complication (NTCP) and the risk of cancer induction were calculated using models with parameters-sets taken from published data for the general population; dose data were taken from dose volume histograms (DVH).Similar dose distributions in the targets were achieved with all techniques but the absorbed doses in the organs-at-risk varied significantly between the different techniques. The NTCP models based on available data predicted very low probabilities for side-effects in all cases. However, the effective mean doses outside the target volumes, and thus the predicted risk of cancer induction, varied significantly between the techniques. The highest lifetime risk of secondary cancers was estimated for IMXT (30%). The lowest risk was found with IMPT (4%). The risks associated with conventional photon therapy, electron therapy and IMET were 20%, 21% and 15%, respectively.This model study shows that spinal irradiation of young children with photon and electron techniques results in a substantial risk of radiation-induced secondary cancers. Multiple beam IMXT seems to be associated with a particularly high risk of secondary cancer induction. To minimise this risk, IMPT should be the treatment of choice. If proton therapy is not available, advanced electron therapy may provide a better alternative.
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| 688. |
- Muniz, Jorge, et al.
(författare)
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Challenges of Engineering Education 5.0 based on I4.0 Policies in Brazil, India, Japan, and Sweden
- 2022
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Ingår i: International Conference on Work Integrated Learning. - Trollhättan : University West. - 9789189325302 ; , s. 95-96
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Industry and academia have placed increasing attention on implementing Industry 4.0 (I4.0) in the production ofgoods and services. Named as Industry 4.0 in Brazil, Made in India in India, Society 5.0 in Japan, andProduktion2030 in Sweden (Ribeiro et al., 2022). Hereafter, we apply I4.0 to simplify, which promises customizedproducts produced in smaller lots, and that repetitive manufacturing tasks can be automated very soon (Karre etal., 2017).Country policies play an important role in pushing different sectors of the economy, aligned as new with theregulatory framework of national and international trade, especially industrial (Aguinis et al., 2020). The implementation of I4.0 literature indicates different specificities in each country, including culture, R&D targets,education and vocational training, and their research opportunities related to how I4.0 affects workers (Jerman etal., 2020). The research-question is: How do different countries approach the opportunities and challenges of Engineering Education 4.0 through similar or different country policies?This study aims to discuss engineering education related to I4.0 policies. This discussion is based on policies fromBrazil, India, Japan, and Sweden related to education and workers 5.0, which include students and employees.Investigating how these countries are adjusting to I4.0 is relevant for national industrial sectors to wish to actefficiently in this new technological context. Industry 4.0 demands new professional skills and will impactemployment. It is noteworthy that this research is in line with the Sustainable Development Goals (SDGs) proposedby the United Nations (UN): Quality Education (SDG-4); o Decent Work and Economic Growth (SDG-8); andIndustry, Innovation, and Infrastructure (ODS-9) which seeks to promote inclusive and sustainableindustrialization and foster innovation. This research aims to contribute to sustainable o rganizational practices;formulation of public policies that alleviate social problems; guidance of professional curricula affected by I 4.0.Papers and Data Selection: A literature search was conducted in the Scopus database, which gathers some of the most important journalsrelated to manufacturing technologies with high impact factors, based on the PRISMA method, which refers to aminimum set of evidence-based items to report studies in systematic reviews and meta -analyses (MOHER et al.,2009). The paper set was assembled from the Scopus core collection, using the following search string: “industry4.0” OR “industry 5.0” AND “policies” AND ". The results were narrowed to texts in English, which yielded 1496papers. All titles and abstracts were read, which resulted in a set composed of 14 papers. We also use official documents relating to I4.0 raised from official government websites.Comparison of Countries’ Education policies and Industry 4.0: The literature addresses difficulties associated with the implementation of I4.0 in emerging economies (Dalagnore,2018; Hong and Muniz Jr., 2022). Not surprisingly, current literature I4.0 related to technology adoption is themost prevalent theme discussed from a hard, technology-oriented perspective rather than a people-oriented.Production systems are sociotechnical systems, with an explicit understanding that all systems involve ongoinginteractions between people and technology, and they are rapidly transforming virtually all areas of human life,work, and interaction.The European Commission’s (Breque et al., 2021) vision for ‘Industry 5.0’ proposes moves past a narrow andtraditional focus on technology-or economic enabled growth of the existing extractive, production andconsumption driven economic model to a more transformative view of growth that is focused on human progressand well-being based on reducing and shifting consumption to new forms of sustainable, circular and regenerativeeconomic value creation and equitable prosperity. This Human-centric production system design and managementapproach (Industry 5.0) is necessary to support skill development, learning, continuous improvement andcollaboration in the organization (Ribeiro et al., 2022).Conclusion: Brazil, India, Japan and Sweden create policies to support their own technological independence. All countriesindicate concern about education and development of skills related to I4.0.It can be concluded that the four countries studied from the perspective of Industry 4.0 an d Engineering Education4.0 are all embarking on their journeys towards increased digitalization in industry and society as a whole. Therealization of the human-centered Society 5.0 was realized and highlighted comparatively early for Japan, whereasin the Europe Union and thus in Sweden the focus of the importance of Industry 5.0 development in parallelIndustry 4.0 has risen up since year 2021.The results indicate that although there are many initiatives of meeting the needs for new competence andknowledge in the era of I4.0 to accommodate Engineering Education 4.0 there are still challenges for futureresearch to move forward in the nexus between I4.0 and I5.0. The result, of studying different countries'policies, highlights that it is imperative, when approaching novel technologies in I4.0 and designing Engineering Education 4.0, to in parallel consider technological implementations with the inclusion of I5.0 aspects and humancentric perspectives.
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| 689. |
- Munn-Chernoff, M. A., et al.
(författare)
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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
- 2021
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Ingår i: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 26:1
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Tidskriftsartikel (refereegranskat)abstract
- Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
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| 690. |
- Mylam, Karen Juul, et al.
(författare)
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F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study
- 2015
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Ingår i: Leukemia & Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 56:7, s. 2005-2012
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Tidskriftsartikel (refereegranskat)abstract
- We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.
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