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  • Result 21-22 of 22
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21.
  • Schumacher, Fredrick R., et al. (author)
  • A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among
  • 2010
  • In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 19:15, s. 3089-3101
  • Journal article (peer-reviewed)abstract
    • The insulin-like growth factor (IGF) pathway has been implicated in prostate development and carcinogenesis. We conducted a comprehensive analysis, utilizing a resequencing and tagging single-nucleotide polymorphism (SNP) approach, between common genetic variation in the IGF1, IGF binding protein (BP) 1, and IGFBP3 genes with IGF-I and IGFBP-3 blood levels, and prostate cancer (PCa) risk, among Caucasians in the NCI Breast and Prostate Cancer Cohort Consortium. We genotyped 14 IGF1 SNPs and 16 IGFBP1/IGFBP3 SNPs to capture common [minor allele frequency (MAF) >= 5%] variation among Caucasians. For each SNP, we assessed the geometric mean difference in IGF blood levels (N = 5684) across genotypes and the association with PCa risk (6012 PCa cases/6641 controls). We present two-sided statistical tests and correct for multiple comparisons. A non-synonymous IGFBP3 SNP in exon 1, rs2854746 (Gly32Ala), was associated with IGFBP-3 blood levels (P-adj = 8.8 x 10(-43)) after adjusting for the previously established IGFBP3 promoter polymorphism A-202C (rs2854744); IGFBP-3 blood levels were 6.3% higher for each minor allele. For IGF1 SNP rs4764695, the risk estimates among heterozygotes was 1.01 (99% CI: 0.90-1.14) and 1.20 (99% CI: 1.06-1.37) for variant homozygotes with overall PCa risk. The corrected allelic P-value was 8.7 x 10(-3). IGF-I levels were significantly associated with PCa risk (P-trend = 0.02) with a 21% increase of PCa risk when compared with the highest quartile to the lowest quartile. We have identified SNPs significantly associated with IGFBP-3 blood levels, but none of these alter PCa risk; however, a novel IGF1 SNP, not associated with IGF-I blood levels, shows preliminary evidence for association with PCa risk among Caucasians.
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22.
  • Severson, Tesa, et al. (author)
  • Androgen receptor reprogramming demarcates prognostic, context-dependent gene sets in primary and metastatic prostate cancer
  • 2022
  • In: Clinical Epigenetics. - : Springer Science and Business Media LLC. - 1868-7075 .- 1868-7083. ; 14:1
  • Journal article (peer-reviewed)abstract
    • The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work has demonstrated that AR-DNA binding is systematically and consistently reprogrammed during prostate tumorigenesis and disease progression. We charted these reprogrammed AR sites and identified genes proximal to them. We were able to devise gene lists based on AR status within specific histological contexts: normal prostate epithelium, primary prostate tumor, and metastatic prostate cancer. We evaluated expression of the genes in these gene sets in subjects from two distinct clinical cohorts—men treated with surgery for localized prostate cancer and men with metastatic prostate cancer. Among men with localized prostate cancer, expression of genes proximal to AR sites lost in the transition from normal prostate to prostate tumor was associated with clinical outcome. Among men with metastatic disease, expression of genes proximal to AR sites gained in metastatic tumors was associated with clinical outcome. These results are consistent with the notion that AR is fundamental to both maintaining differentiation in normal prostate tissue and driving de-differentiation in advanced prostate cancer. More broadly, the study demonstrates the power of incorporating context-dependent epigenetic data into genetic analyses.
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  • Result 21-22 of 22
Type of publication
journal article (21)
conference paper (1)
Type of content
peer-reviewed (22)
Author/Editor
Albanes, Demetrius (9)
Haiman, Christopher ... (8)
Kraft, Peter (8)
Brennan, Paul (7)
Riboli, Elio (6)
Henderson, Brian E (6)
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Chanock, Stephen J (6)
Cybulski, Cezary (6)
Severi, Gianluca (6)
Johansson, Mattias (6)
Yeager, Meredith (6)
Hunter, David J (6)
Wolk, Alicja (5)
Stevens, Victoria L (5)
Cancel-Tassin, Geral ... (5)
Koutros, Stella (5)
White, Emily (5)
Zheng, Wei (5)
Easton, Douglas F. (5)
Huang, Wen-Yi (5)
Foretova, Lenka (5)
Scelo, Ghislaine (5)
Overvad, Kim (4)
Kaaks, Rudolf (4)
Boeing, Heiner (4)
Gapstur, Susan M (4)
Freedman, Barry I. (4)
Larsson, Susanna C. (4)
Peters, Ulrike (4)
Canzian, Federico (4)
Dunning, Alison M. (4)
Lissowska, Jolanta (4)
Shu, Xiao-Ou (4)
Gaziano, J Michael (4)
Kolonel, Laurence N (4)
Le Marchand, Loïc (4)
Stram, Daniel O (4)
Fletcher, Tony (4)
Rotter, Jerome I. (4)
Lipworth, Loren (4)
Boland, Anne (4)
Deleuze, Jean-Franco ... (4)
Brown, Kevin M (4)
Holcatova, Ivana (4)
Zaridze, David (4)
Mates, Dana (4)
Janout, Vladimir (4)
Bencko, Vladimir (4)
Rudnai, Peter (4)
Fabianova, Eleonora (4)
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University
Umeå University (10)
Uppsala University (10)
Karolinska Institutet (7)
Lund University (6)
Linköping University (2)
University of Gothenburg (1)
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Luleå University of Technology (1)
Stockholm University (1)
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Language
English (22)
Research subject (UKÄ/SCB)
Medical and Health Sciences (17)
Natural sciences (1)
Engineering and Technology (1)

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