| 41. |
- Frey, H. U., et al.
(författare)
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Small and meso-scale properties of a substorm onset auroral arc
- 2010
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 115, s. A10209-
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Tidskriftsartikel (refereegranskat)abstract
- We present small and meso-scale properties of a substorm onset arc observed simultaneously by the Reimei and THEMIS satellites together with ground-based observations by the THEMIS GBO system. The optical observations revealed the slow equatorward motion of the growth-phase arc and the development of a much brighter onset arc poleward of it. Both arcs showed the typical particle signature of electrostatic acceleration in an inverted-V structure together with a strong Alfven wave acceleration signature at the poleward edge of the onset arc. Two THEMIS spacecraft encountered earthward flow bursts around the times the expanding optical aurora reached their magnetic footprints in the ionosphere. The particle and field measurements allowed for the reconstruction of the field-aligned current system and the determination of plasma properties in the auroral source region. Auroral arc properties were extracted from the optical and particle measurements and were used to compare measured values to theoretical predictions of the electrodynamic model for the generation of auroral arcs. Good agreement could be reached for the meso-scale arc properties. A qualitative analysis of the internal structuring of the bright onset arc suggests the operation of the tearing instability which provides a 'rope-like' appearance due to advection of the current in the sheared flow across the arc. We also note that for the observed parameters ionospheric conductivity gradients due to electron precipitation will be unstable to the feedback instability in the ionospheric Alfven resonator that can drive structuring in luminosity over the range of scales observed.
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| 47. |
- Hosokawa, Keisuke, et al.
(författare)
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Aurora in the Polar Cap : A Review
- 2020
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Ingår i: Space Science Reviews. - : Springer. - 0038-6308 .- 1572-9672. ; 216:1
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Forskningsöversikt (refereegranskat)abstract
- This paper reviews our current understanding of auroral features that appear poleward of the main auroral oval within the polar cap, especially those that are known as Sun-aligned arcs, transpolar arcs, or theta auroras. They tend to appear predominantly during periods of quiet geomagnetic activity or northwards directed interplanetary magnetic field (IMF). We also introduce polar rain aurora which has been considered as a phenomenon on open field lines. We describe the morphology of such auroras, their development and dynamics in response to solar wind-magnetosphere coupling processes, and the models that have been developed to explain them.
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| 48. |
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| 50. |
- Khaleva, E, et al.
(författare)
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Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
- 2023
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 61:4
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Tidskriftsartikel (refereegranskat)abstract
- Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) working group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies.MethodsCOMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult, and paediatric clinicians, pharmaceutical representatives and health regulators from across Europe. Evidence included a systematic review of development, validity, and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria.ResultsBoth adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire, and Asthma Control Test (ACT) or Childhood-ACT while the adult COM includes the Severe Asthma Questionnaire and the Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately).ConclusionsThis patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.
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