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Sökning: WFRF:(Gidlof S)

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31.
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34.
  • Rudnicki, M, et al. (författare)
  • When endometriosis is the barrier for fertility
  • 2017
  • Ingår i: Acta obstetricia et gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 96:6, s. 621-622
  • Tidskriftsartikel (refereegranskat)
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35.
  • Solders, M., et al. (författare)
  • Mature naive B cells are retained in the placental intervillous blood and positively associate with specific chemokines in full-term healthy pregnancy
  • 2019
  • Ingår i: American Journal of Reproductive Immunology. - : Wiley. - 1046-7408 .- 1600-0897. ; 82:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Problem Circulating B-cell numbers are lower during pregnancy compared with non-pregnant women, but the underlying reasons for this are unknown. Pregnancy-related hormones could influence B-cell lymphopoiesis in the bone marrow, but B cells may also be recruited to the placenta. To investigate the latter, we examined whether the proportions of total B cells and B cells at different maturational stages in placental intervillous blood (IVB) differ compared with peripheral blood (PB). Method of study From 23 paired samples of PB and IVB following full-term healthy pregnancies, total B cells and immature/transitional, mature/naive, and memory B cells were identified by flow cytometry. Chemokine levels in blood were analyzed using a Luminex assay. Placental explant-derived supernatant was assayed for B-cell chemotactic activity. Results The proportions of total B cells and mature/naive B cells were significantly higher in IVB relative to PB, while the fractions of immature/transitional cells and memory B cells were higher in PB. Multivariate factor analysis demonstrated that a specific chemokine profile in IVB, including CCL20, positively associated with higher proportions of mature/naive B cells in the intervillous space. All B cells expressed CCR6, the corresponding receptor for CCL20, but the intensity of CCR6 expression was significantly higher in mature/naive B cells relative to immature/transitional B cells. Migration assays showed that placental explant-derived supernatants attract B cells. Conclusion These results indicate that B cells, and mature/naive B cells in particular, are retained in the intervillous blood in response to certain chemokines produced by the placenta during late healthy pregnancy.
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36.
  • Trifunovic, A, et al. (författare)
  • Creation of mtDNA mutator mice
  • 2004
  • Ingår i: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. - 0005-2728. ; 1657, s. 21-21
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Resultat 31-37 av 37

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