| 31. |
- Maddock, Jane, et al.
(författare)
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Vitamin D and cognitive function : A Mendelian randomisation study.
- 2017
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.
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| 32. |
- Marcinkevicius, Benjaminas, et al.
(författare)
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Fuel ion ratio determination using the 14 MeV Tandem neutron spectrometer for JET DTE1 campaign discharges
- 2022
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Ingår i: Fusion engineering and design. - : Elsevier. - 0920-3796 .- 1873-7196. ; 184
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates the determination of the fuel ion ratio nT/ntot in fusion experiments using two different approaches. The methods are applied to plasma discharges from the deuterium-tritium campaign at the Joint European Torus (JET) in 1997. Multiple discharges have been analysed using data acquired with the Tandem (KM2) neutron spectrometer, using a new neutron spectrometer response function and improved line-of-sight information.The two different approaches were generally similar with the exception of the beam slowing down modelling, handled by two different particle transport codes, namely, TRANSP and PENCIL.The results show that nT/ntot can be determined using Tandem neutron spectrometer data; nT/ntot using both of the approaches are consistent and within the uncertainty for a range of studied discharges.The obtained results support previous studies on nT/ntot determination using neutron spectroscopy. In addition, we have shown that PENCIL can be used instead of TRANSP for a range of discharges which could simplify and speed up the estimation of nT/ntot. The possible limitations of the approach using PENCIL could be investigated using different neutron spectrometer data from the 2021 JET deuterium-tritium campaign.A similar spectrometer like Tandem is planned to be operational at ITER and the results of this paper form the first experimental verification of the capability for nT/ntot measurements with such spectrometers. Further research on this could lead to better understanding of these instruments and their limitations before the start of experiments at ITER.
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| 33. |
- Mattsson, Cecilia, et al.
(författare)
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[Thyrotoxicosis]
- 2004
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Ingår i: Lakartidningen. - 0023-7205. ; 101:42, s. 3249-52
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Tidskriftsartikel (refereegranskat)
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| 34. |
- Mjörndal, Tom, et al.
(författare)
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Adverse drug reactions as a cause for admissions to a department of internal medicine.
- 2002
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Ingår i: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 11:1, s. 65-72
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To assess the occurrence and pattern of adverse drug reactions as a cause for acute hospital admission.METHODS: In 681 randomly selected patients, acutely admitted to a clinic of internal medicine at a Swedish university hospital, information was collected from their medical records about current symptoms and use of drugs, previous diseases and the results of medical investigations and tests. In addition, a standardized interview according to a questionnaire was carried out. A group of experts in clinical pharmacology assessed the data obtained from the patients' case records and the results of the interviews, and then, according to WHO criteria, judged the probability that an adverse drug reaction could have caused or contributed to the actual admission to hospital.RESULTS: Out of the 681 cases included, 94 (13.8%) had symptoms and signs that were judged as drug-related and that had caused or contributed to the admission. Eighty-two patients (12.0%) had altogether 99 symptoms that were classified as adverse drug reactions. Of these, 91% were type A reactions. The relationship between the medication and the reaction was judged certain in eight, probable in 17, and possible in 74 cases. The most common adverse drug reactions were cardiovascular (36.3%). Twelve patients (1.8%) had symptoms indicating intoxications.CONCLUSIONS: The prevalence of drug-related problems causing or contributing to admission to a clinic of internal medicine is high and is dominated by type A reactions, i.e. reactions in principle predictable and preventable. This implies a possibility to increase drug safety by preventive measures.
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| 35. |
- Ohlander, Ulrika, et al.
(författare)
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Performance using low-cost gaze-control for simulated flight tasks
- 2016
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Ingår i: Proceedings of the Human Factors and Ergonomics Society Europe Chapter 2016 Annual Conference. ; , s. 201-210
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Konferensbidrag (refereegranskat)abstract
- In the current study, interaction using gaze control was compared to computer mouse using the MATB-II (Multi-Attribute Task Battery) environment. The study had two aims; the first was to explore the utility of low-cost technologies in a rapid prototyping and testing environment for aviation. The second aim was to use such an environment to compare a novel interaction device (a low-cost gaze control device) to a familiar interaction device (computer mouse). Method: Thirty participants performed two scenarios with each interaction device. The software MATB-II provided simulated flight tasks and recorded performance. Mental workload was assessed by the NASA Task Load Index (TLX) questionnaire after each scenario. Results: The results showed that gaze control resulted in significantly higher overall mental workload than computer mouse. Performance was better with mouse in two of the four tasks. Conclusions: Concerning the first aim, the study demonstrated the value of low-cost technology for initial user testing before using more expensive high-fidelity environments. Concerning the second aim, the computer mouse resulted in better performance and lower mental workload. This may either be due to higher user familiarity with computer mouse interaction or to limitations of the gaze control equipment and insufficient adjustments of the interface design to optimize for gaze control.
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| 36. |
- Omstedt, Anders, 1949, et al.
(författare)
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Future changes in the Baltic Sea acid-base (pH) and oxygen balances
- 2012
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Ingår i: Tellus. Series B, Chemical and physical meteorology. - : Stockholm University Press. - 0280-6509 .- 1600-0889. ; 64
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Tidskriftsartikel (refereegranskat)abstract
- Possible future changes in Baltic Sea acid–base (pH) and oxygen balances were studied using a catchment–sea coupled model system and numerical experiments based on meteorological and hydrological forcing datasets and scenarios. By using objective statistical methods, climate runs for present climate conditions were examined and evaluated using Baltic Sea modelling. The results indicate that increased nutrient loads will not inhibit future Baltic Sea acidification; instead, the seasonal pH cycle will be amplified by increased biological production and mineralization. All examined scenarios indicate future acidification of the whole Baltic Sea that is insensitive to the chosen global climate model. The main factor controlling the direction and magnitude of future pH changes is atmospheric CO2 concentration (i.e. emissions). Climate change and land-derived changes (e.g. nutrient loads) affect acidification mainly by altering the seasonal cycle and deep-water conditions. Apart from decreasing pH, we also project a decreased saturation state of calcium carbonate, decreased respiration index, and increasing hypoxic area – all factors that will threaten the marine ecosystem. We demonstrate that substantial reductions in fossil-fuel burning are needed to minimize the coming pH decrease and substantial reductions in nutrient loads are needed to reduce the coming increase in hypoxic and anoxic waters.
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| 37. |
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| 38. |
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| 39. |
- Reuterving, Carl-Olof, 1946-
(författare)
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Salivary glands and oral lesions in diabetes mellitus : an experimental and clinical study with special reference to the influence of metabolic control and duration of the disease
- 1987
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Diabetes mellitus is associated with several clinically significant abnormalities in the oral cavity and salivary glands, the most common being periodontitis, salivary gland enlargement and a sensation of dry mouth. The prevalence of dental caries in diabetics is mostly reported to be decreased or unaffected. Since there is a shortage of information concerning the influence of metabolic control and duration of diabetes on these abnormalities, the present studies were performed.Three-month-old rats were made alloxan-diabetic and investigated after one and twelve months’ duration of diabetes for oral lesions and feeding behavior. They had free access to a standard pellet diet and tap water. Streptococcus mutans and lactobacilli were naturally occurring. In diabetic rats the proportion of the oral flora which was lactobacilli was positively correlated to the blood glucose level. Untreated long-term alloxan-diabetic rats developed advanced periodontal disease and root surface caries in the molars at sites of interdental impaction of foreign material. The degree of alveolar bone loss was positively correlated to the blood glucose level. Diabetic rats were hyperphagic and had a longer total eating time, including day-time eating, mainly by having longer meals but no significant increase of meal frequency, as compared with non-diabetic animals. The untreated alloxan-diabetic rats developed reduced salivary gland weight which was of the same degree in short- and longterm diabetic animals. Short- and long-term untreated alloxan-diabetic rats showed a similar degree of morpho- metrically estimated lipid accumulation in the acinar cells of the submandibular glands, and the degree was positively correlated to the blood glucose level. However, lipid inclusion occurred only in rats with a morning nonfasting blood glucose level exceeding 15 mmol/L. The capillaries in the submandibular glands of the untreated long-term alloxan-diabetic rats had a significantly increased thickness of the basement membranes as compared with the observations in short-term diabetic and non-diabetic rats. Untreated alloxan-diabetic rats were also shown to have a decreased salivary flow rate compared with non-diabetic rats, and the decreased flow was negatively correlated to the blood glucose concentration. Salivary flow rate increased with the duration of the disease. The diabetic rats had increased salivary glucose levels, which were positively correlated to blood glucose values when the latter were above 15 mmol/L, suggesting a threshold mechanism for salivary glucose excretion. Insulin therapy reversed salivary flow rate and salivary glucose concentrations toward normal.Salivary investigations were performed in eleven diabetic patients on two occasions with different metabolic control. Salivary flow rate showed marked interindividual differences but was not significantly changed by improved metabolic control although several of the patients initially had severely deranged glucose metabolism. A positive correlation between the glucose concentration in blood and saliva was seen in the parotid saliva during secretory stimulation. No significant change in electrolytes, amylase or antimicrobial factors was found.
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| 40. |
- Rezagholi, Mahmoud
(författare)
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Cost-Efficient Designs for Assessing Work-Related Biomechanical Exposures
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Work-related disorders due to biomechanical exposures have been subject to extensive research. Studies addressing these exposures have, however, paid limited attention to an efficient use of resources in exposure assessment. The present thesis investigates cost-efficient procedures for assessment of work-related biomechanical exposures, i.e. procedures aiming at a proper balance between statistical and economic performance.Paper I is a systematic review of tools used in literature providing cost-efficient data collection designs. Two main approaches were identified in nine publications, i.e. comparing cost efficiency among alternative data collection designs, and optimizing resource allocation between different stages of data collection, e.g. subjects and samples within subjects. The studies presented, in general, simplified analyses, in particular with respect to economics.Paper II compared the cost-efficiency of four video-based techniques for assessing upper arm postures. The comparison was based both on a comprehensive model of cost and error and additionally on two simplified models. Labour costs were a dominant factor in the cost efficiency comparison. Measurement bias and costs other than labour cost influenced the rank and economic evaluation of the assessment techniques.Paper III compared the cost efficiency of different combinations of direct and indirect methods for exposure assessments. Although a combination of methods could significantly reduce the total cost of obtaining a desired level of precision, the total cost was, in the investigated scenario, lowest when only direct measurements were performed. However, when the total number of measurements was fixed, a combination was the most cost efficient choice.In Paper IV, demand functions were derived for a four-stage measurement strategy with the focus of either minimizing the cost for a required precision, or maximizing the precision for a predetermined budget. The paper presents algorithms for identifying optimal values of measurement inputs at all four stages, adjusted to integers, as necessary for practical application.In summary, the thesis shows that it is important to address all sources of costs and errors associated with alternative measurement designs in any particular study, and that an optimal determination of samples at different stages can be identified in several cases not previously addressed in the literature.
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