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- Undorf, Sabine, et al.
(författare)
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Learning from the 2018 heatwave in the context of climate change : are high-temperature extremes important for adaptation in Scotland?
- 2020
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 15:3
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Tidskriftsartikel (refereegranskat)abstract
- To understand whether high temperatures and temperature extremes are important for climate change adaptation in Scotland, we place the 2018 heatwave in the context of past, present, and future climate, and provide a rapid but comprehensive impact analysis. The observed hottest day (d), 5 d, and 30 d period of 2018 and the 5 d period with the warmest nights had return periods of 5-15 years for 1950-2018. The warmest night and the maximum 30 d average nighttime temperature were more unusual with return periods of >30 years. Anthropogenic climate change since 1850 has made all these high-temperature extremes more likely. Higher risk ratios are found for experiments from the CMIP6-generation global climate model HadGEM3-GA6 compared to those from the very-large ensemble system weather@home. Between them, the best estimates of the risk ratios for daytime extremes range between 1.2-2.4, 1.2-2.3, and 1.4-4.0 for the 1, 5, and 30 d averages. For the corresponding nighttime extremes, the values are higher and the ranges wider (1.5- >50, 1.5-5.5, and 1.6- >50). The short-period nighttime extremes were more likely in 2018 than in 2017, suggesting a contribution from year-to-year climate variability to the risk enhancement of extreme temperatures due to anthropogenic effects. Climate projections suggest further substantial increases in the likelihood of 2018 temperatures between now and 2050, and that towards the end of the century every summer might be as hot as 2018. Major negative impacts occurred, especially on rural sectors, while transport and water infrastructure alleviated most impacts by implementing costly special measures. Overall, Scotland could cope with the impacts of the 2018 heatwave. However, given the likelihood increase of high-temperature extremes, uncertainty about consequences of even higher temperatures and/or repeated heatwaves, and substantial costs of preventing negative impacts, we conclude that despite its cool climate, high-temperature extremes are important to consider for climate change adaptation in Scotland.
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| 24. |
- van Dongen, J, et al.
(författare)
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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
- 2021
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Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 26:6, s. 2148-2162
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Tidskriftsartikel (refereegranskat)abstract
- DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3–82%) of the aggression–methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.
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