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- Abolfathi, Bela, et al.
(författare)
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The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
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Tidskriftsartikel (refereegranskat)abstract
- The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
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- Ahearn, Thomas U., et al.
(författare)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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- Almroth Rosell, Elin, 1977, et al.
(författare)
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Effects of simulated natural and massive resuspension on benthic oxygen, nutrient and dissolved inorganic carbon fluxes in Loch Creran, Scotland
- 2012
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Ingår i: Journal of Sea Research. - : Elsevier BV. - 1385-1101. ; 72
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Tidskriftsartikel (refereegranskat)abstract
- The effect of repeated natural resuspension on benthic oxygen consumption and the effect of natural and massive resuspension on oxygen consumption and fluxes of phosphate, silicate, ammonium and dissolved inorganic carbon (DIC) were studied at two stations (S1 and S2) in a Scottish sea loch. Station S11 had organically enriched sediment and station S1 had lower organic content in the sediment. The fluxes were measured in situ using the Göteborg benthic lander. Natural resuspension, simulating resuspension events due to strong wind, waves or currents, and massive resuspension, simulating resuspension due to e.g. trawling or dredging, were created inside the incubation chambers by regulating the stirring of the incubated overlying water or by retracting and shaking the incubated sediment. Natural resuspension showed clear effects on the oxygen consumption at station S11, where it increased with an average of 12.8 (standard error (s.e.) 0.17) and 7.7 (s.e. 0.12) mmol m− 2 d− 1 during the first and second incubations, respectively. At station S1 there was no clear effect of natural resuspension on the oxygen consumption. Massive resuspension increased the oxygen consumption on S1 with an average of 608 (standard deviation (sd) 366) mmol m− 2 d− 1 and on S11 with an average of 2396 (sd 2265) mmol m− 2 d− 1. The fluxes of ammonium, phosphate and silicate were affected by the massive resuspension in 50, 14 and 33% of the chambers, respectively, on station S11. However, in the majority of the cases there were no effects on the nutrient and DIC fluxes of massive resuspension. The absolute concentrations of DIC, ammonium and silicate did however instantly increase with an average of 419 (sd 297), 48 (sd 27) and 6.9 (sd 3.7) μM, respectively, at S11 upon massive resuspension. The concentrations of phosphate decreased instantly with an average of 0.2 (sd 0.1) μM. On station S1 there were effects only on the ammonium and silicate concentrations, which increased with 0.8 (sd 0.3) and 1.13 (sd 0.36) μM, respectively. The large increase in oxygen consumption due to massive resuspension indicates that activities like e.g. trawling and dredging that take place in areas where water exchange occurs infrequently may lead to oxygen depletion in bottom water, which in turn might affect the ecological balance. Silicate, ammonium and DIC can be released due to massive resuspension and contribute to increased algal blooms in surface waters.
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