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Numrering	Referens	Omslagsbild	Hitta
51.	Ji, LN, et al. (författare) Early versus late intensification of glucose-lowering therapy in patients with type 2 diabetes: Results from the DISCOVER study 2021 Ingår i: Diabetes research and clinical practice. - : Elsevier BV. - 1872-8227 .- 0168-8227. ; 178, s. 108947- Tidskriftsartikel (refereegranskat)
52.	Karlsson, Cecilia, 1968, et al. (författare) Identification of Proteins Associated with the Early Restoration of Insulin Sensitivity After Biliopancreatic Diversion 2020 Ingår i: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 105:11 Tidskriftsartikel (refereegranskat)abstract Context: Insulin resistance (IR) is a risk factor for type 2 diabetes, diabetic kidney disease, cardiovascular disease and nonalcoholic steatohepatitis. Biliopancreatic diversion (BPD) is the most effective form of bariatric surgery for improving insulin sensitivity. Objective: To identify plasma proteins correlating with the early restoration of insulin sensitivity after BPD. Design: Prospective single-center study including 20 insulin-resistant men with morbid obesity scheduled for BPD. Patient characteristics and blood samples were repeatedly collected from baseline up to 4 weeks postsurgery. IR was assessed by homeostatic model assessment for insulin resistance (HOMA-IR), Matsuda Index, and by studying metabolic profiles during meal tolerance tests. Unbiased proteomic analysis was performed to identify plasma proteins altered by BPD. Detailed plasma profiles were made on a selected set of proteins by targeted multiple reaction monitoring mass spectrometry (MRM/MS). Changes in plasma proteome were evaluated in relation to metabolic and inflammatory changes. Results: BPD resulted in improved insulin sensitivity and reduced body weight. Proteomic analysis identified 29 proteins that changed following BPD. Changes in plasma levels of afamin, apolipoprotein A-IV (ApoA4), and apolipoprotein A-II (ApoA2) correlated significantly with changes in IR. Conclusion: Circulating levels of afamin, ApoA4, and ApoA2 were associated with and may contribute to the rapid improvement in insulin sensitivity after BPD.
53.	Khunti, K, et al. (författare) Prevalence and progression of chronic kidney disease among patients with type 2 diabetes: Insights from the DISCOVER study 2021 Ingår i: Diabetes, obesity & metabolism. - : Wiley. - 1463-1326 .- 1462-8902. ; 23:8, s. 1956-1960 Tidskriftsartikel (refereegranskat)
54.	Linnersjo, A, et al. (författare) Recent time trends in acute myocardial infarction in Stockholm, Sweden 2000 Ingår i: International journal of cardiology. - : Elsevier BV. - 0167-5273. ; 76:1, s. 17-21 Tidskriftsartikel (refereegranskat)
55.	Ljungkvist, G, et al. (författare) Study on the origin and collection of exogenous compounds in exhaled breath aerosol particles 2015 Ingår i: EUROPEAN RESPIRATORY JOURNAL. - 0903-1936. ; 46 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
56.	Miyazaki, N, et al. (författare) The functional organization of the internal components of Rice dwarf virus 2010 Ingår i: Journal of biochemistry. - : Oxford University Press (OUP). - 1756-2651 .- 0021-924X. ; 147:6, s. 843-850 Tidskriftsartikel (refereegranskat)
57.	Nakamura, M, et al. (författare) Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma 2019 Ingår i: Oncoimmunology. - 2162-4011. ; 8:6, s. e1593811- Tidskriftsartikel (refereegranskat)
58.	Nasman, A, et al. (författare) Incidence of human papillomavirus positive tonsillar and base of tongue carcinoma: a stabilisation of an epidemic of viral induced carcinoma? 2015 Ingår i: European journal of cancer (Oxford, England : 1990). - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 51:1, s. 55-61 Tidskriftsartikel (refereegranskat)
59.	Nichols, Aaron L., et al. (författare) Selective Serotonin Reuptake Inhibitors within Cells : Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane 2023 Ingår i: Journal of Neuroscience. - : SOC NEUROSCIENCE. - 0270-6474 .- 1529-2401. ; 43:13, s. 2222-2241 Tidskriftsartikel (refereegranskat)abstract Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depres-sive disorder. The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin transporter (SERT) are poorly understood, partially because no studies exist on the cellular and subcellular pharmacokinetic properties of SSRIs in living cells. We studied escitalopram and fluoxetine using new intensity-based, drug-sensing fluorescent reporters targeted to the plasma membrane, cytoplasm, or endoplasmic reticulum (ER) of cultured neurons and mammalian cell lines. We also used chemical detection of drug within cells and phospholipid membranes. The drugs attain equilibrium in neuronal cytoplasm and ER at approximately the same concentration as the externally applied solution, with time constants of a few s (escitalopram) or 200-300 s (fluoxetine). Simultaneously, the drugs accumulate within lipid membranes by >18-fold (escitalo-pram) or 180-fold (fluoxetine), and possibly by much larger factors. Both drugs leave cytoplasm, lumen, and membranes just as quickly during washout. We synthesized membrane-impermeant quaternary amine derivatives of the two SSRIs. The qua-ternary derivatives are substantially excluded from membrane, cytoplasm, and ER for .2.4 h. They inhibit SERT transport -associated currents sixfold or 11-fold less potently than the SSRIs (escitalopram or fluoxetine derivative, respectively), provid-ing useful probes for distinguishing compartmentalized SSRI effects. Although our measurements are orders of magnitude faster than the therapeutic lag of SSRIs, these data suggest that SSRI-SERT interactions within organelles or membranes may play roles during either the therapeutic effects or the antidepressant discontinuation syndrome.
60.	Nicolucci, A, et al. (författare) Quality of life in people with type 2 diabetes in the 3 years following initiation of second-line therapy: The DISCOVER study 2022 Ingår i: Diabetes research and clinical practice. - : Elsevier BV. - 1872-8227 .- 0168-8227. ; 185, s. 109218- Tidskriftsartikel (refereegranskat)

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Författare/redaktör: Hammar, N (115); Fenici, P (31); Kosiborod, M. (29); Hammar, U. (29); Khunti, K (27); Walldius, G (23); visa fler...; Nicolucci, A (21); Hammar, M (21); Shestakova, MV (20); Watada, H (19); Hammar, Mattias (18); Gomes, MB (18); Shimomura, I (14); Cid-Ruzafa, J (13); Medina, J (12); Ji, LN (11); Cooper, A (11); Berggren, Jesper (11); Rathmann, W (11); Jankowska, Elzbieta (11); Hammar, Ingela, 1964 (11); Chen, HT (10); Surmont, F (10); Alfredsson, L (10); Ahlbom, A (10); Tang, FM (10); Tang, F. (9); Pocock, S. (9); Van Hemelrijck, M (9); Pukkala, E (8); Charbonnel, B (8); Norhammar, A. (8); Arnold, SV (8); Thuresson, M (8); Eliasch, H (8); Birkeland, KI (7); Auvinen, A (7); Hedlin, G (7); Ekbom, A (7); Soderhall, C (7); Haldorsen, T (7); Karlsson, U. O. (7); Farnert, A (7); Wettermark, B (7); Ji, L (7); Jungner, I (7); Leimanis, A (7); Cavender, MA (7); Fu, AZ (7); Chelnokov, A. (7); visa färre...

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