SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Hashimoto S.) "

Sökning: WFRF:(Hashimoto S.)

  • Resultat 61-70 av 242
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  • Östling, Jörgen, et al. (författare)
  • IL-17-high asthma with features of a psoriasis immunophenotype
  • 2019
  • Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 144:5, s. 1198-1213
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required.Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity.Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n = 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes.Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and β-defensin.Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
  •  
62.
  • Asano, H., et al. (författare)
  • Spectroscopic study of the Λ(1405) resonance via the d (K-, n) reaction at J-PARC
  • 2019
  • Ingår i: 13th International Conference on Hypernuclear and Strange Particle Physics, HYP 2018. - : AIP Publishing. - 9780735418721 ; 2130
  • Konferensbidrag (refereegranskat)abstract
    • The structure of the Λ(1405) hyperon is an important and long-standing issue related to the K̄-nucleus interaction. The J-PARC E31 experiment has been performed to investigate the Λ(1405) spectrum shape. Because it is hard to form the Λ(1405) directly by a K̄N scattering in free space, E31 uses the d(K-, n) reaction with an incident kaon momentum of 1 GeV/c. We will identify three final states - ς-π+, ς+π-, ς0π0-so that the isospin structure of hyperon resonance states produced can be decomposed. The first physics run of the E31 experiment was performed in 2016. To enhance the statistics of the data set, we have performed the second physics run in the beginning of 2018. During the second run of E31, around 3.9×1010 kaons impacted on the deuteron target.
  •  
63.
  •  
64.
  •  
65.
  •  
66.
  •  
67.
  • Sada, Y., et al. (författare)
  • Structure near the K- + p + p threshold in the in-flight 3He(K-, Λp)n reaction
  • 2016
  • Ingår i: Progress of Theoretical and Experimental Physics. - : Oxford University Press (OUP). - 2050-3911. ; 2016:5
  • Tidskriftsartikel (refereegranskat)abstract
    • To search for an S = -1 di-baryonic state which decays toΛp, the 3He(K-,Λp)nmissing reaction was studied at 1.0 GeV/c. Unobserved neutrons were kinematically identified from the missing mass MX of the 3He (K-,Λp) X reaction in order to have a large acceptance for the Λpn final state. The observed Λpn events, distributed widely over the kinematically allowed region of the Dalitz plot, establish that the major component comes from a three-nucleon absorption process. A concentration of events at a specific neutron kinetic energy was observed in a region of low momentum transfer to the Λp. To account for the observed peak structure, the simplest S-wave polewas assumed to exist in the reaction channel, having a Breit-Wigner formin energy and with a Gaussian form factor. A minimum X2 method was applied to deduce its mass, MX = 2355+6 -8 (stat.) ±12 (syst.)MeV/c2, and decay width, γX = 110+19 -17 (stat.) ±27 (syst.)MeV/c2, respectively. The form factor parameter QX ∼ 400MeV/c implies that the range of the interaction is about 0.5 fm.
  •  
68.
  •  
69.
  • Yamaga, Takumi, et al. (författare)
  • Study of the elementary (K -, n) reactions to search for the K NN bound state via the 3He (K -, n) reaction at J-PARC
  • 2016
  • Ingår i: XVIth International Conference on Hadron Spectroscopy, Hadron 2015. - : Author(s). - 9780735413894 ; 1735
  • Konferensbidrag (refereegranskat)abstract
    • We have searched for the simplest kaonic nuclear state, K̄NN, using the in-flight 3He (K-, n) reaction at the J-PARC hadron experimental facility. In the semi-inclusive neutron missing-mass spectrum at θnlab=0°, an excess of yield was observed just below the K- pp mass-threshold, which cannot be explained by any elementary reactions [PTEP 2015, 061D01]. To understand the missing-mass spectrum of 3He (K-, n) X, we investigated the elementary (K-, n) reactions using hydrogen and deuterium targets. The p (K-, n) X missing-mass spectrum was well described by the charge-exchange reaction. However, in the d (K-, n) X spectrum, we observed an excess of yield just below the K- p mass-threshold, which was similar to that in the 3He (K-, n) X spectrum.
  •  
70.
  • Khaleva, E, et al. (författare)
  • Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
  • 2023
  • Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 61:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) working group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies.MethodsCOMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult, and paediatric clinicians, pharmaceutical representatives and health regulators from across Europe. Evidence included a systematic review of development, validity, and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria.ResultsBoth adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire, and Asthma Control Test (ACT) or Childhood-ACT while the adult COM includes the Severe Asthma Questionnaire and the Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately).ConclusionsThis patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-70 av 242
Typ av publikation
tidskriftsartikel (195)
konferensbidrag (39)
forskningsöversikt (4)
annan publikation (1)
Typ av innehåll
refereegranskat (202)
övrigt vetenskapligt/konstnärligt (37)
Författare/redaktör
Watanabe, K. (27)
Kwon, Y. (24)
Tanaka, Y. (24)
Nakamura, T. (23)
Grau, N. (23)
Alexander, J (22)
visa fler...
Oskarsson, Anders (21)
Stenlund, Evert (21)
Hill, J. C. (21)
Jia, J. (21)
Milov, A. (21)
Vrba, V. (21)
Lebedev, A. (21)
Tomasek, M. (21)
Bathe, S. (21)
Kim, Y. J. (21)
Park, S. K. (21)
Sukhanov, A. (21)
Awes, T. C. (21)
Buesching, H. (21)
Christiansen, Peter (21)
Chujo, T. (21)
Enokizono, A. (21)
Glenn, A. (21)
Gunji, T. (21)
Hamagaki, H. (21)
Inaba, M. (21)
Kang, J. H. (21)
Khanzadeev, A. (21)
Kim, D. J. (21)
Lee, K. S. (21)
Miake, Y. (21)
Okada, K. (21)
Ozawa, K. (21)
Rak, J. (21)
Read, K. F. (21)
Samsonov, V. (21)
Shigaki, K. (21)
Shimomura, M. (21)
Sugitate, T. (21)
Torii, H. (21)
Esumi, S. (21)
Garishvili, I. (21)
Mohanty, A. K. (21)
Nagle, J. L. (21)
Shukla, P. (21)
Hanks, J. (21)
Petti, R. (21)
Fleuret, F. (21)
Belmont, R. (21)
visa färre...
Lärosäte
Karolinska Institutet (132)
Lunds universitet (37)
Stockholms universitet (34)
Göteborgs universitet (21)
Uppsala universitet (18)
Umeå universitet (11)
visa fler...
Kungliga Tekniska Högskolan (11)
Chalmers tekniska högskola (9)
Karlstads universitet (7)
Linköpings universitet (3)
Naturhistoriska riksmuseet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (242)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (94)
Medicin och hälsovetenskap (43)
Teknik (13)
Lantbruksvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy