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Sökning: WFRF:(Heikkila R)

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51.
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52.
  • Tynninen, O, et al. (författare)
  • Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
  • 2002
  • Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 86:12, s. 1905-1908
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.
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53.
  • Villman, Kenneth, et al. (författare)
  • TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer
  • 2006
  • Ingår i: Acta Oncol. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 45:5, s. 590-6
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this study was to evaluate amplification of topoisomerase IIalpha (TOP2A) and HER2 genes as predictors of response to chemotherapy in advanced breast cancer. Gene copy number of TOP2A and HER2 were analysed with chromogenic in situ hybridization (CISH) on paraffin-embedded tissue sections from the primary tumour of 85 patients treated with anthracycline containing chemotherapy. TOP2A gene amplification was present in 14 (16%) and HER2 gene amplification in 38 (45%) of the primary tumours. Two of the 14 cases with TOP2A amplification were amplified without concurrent HER2 amplification. Neither TOP2A nor HER2 gene amplification were significantly associated with response to chemotherapy (p = 0.35 and p = 0.49, respectively).
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54.
  • Vuoksimaa, E, et al. (författare)
  • Aggression and academic performance
  • 2017
  • Ingår i: BEHAVIOR GENETICS. - 0001-8244. ; 47:6, s. 656-656
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
  •  
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  • Resultat 51-54 av 54
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tidskriftsartikel (47)
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Heikkila, P (12)
Kaprio, J (8)
Blomqvist, C (8)
Andrulis, IL (8)
Willemsen, G (7)
Boomsma, DI (7)
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Hall, P (7)
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Chang-Claude, J (7)
Nevanlinna, H (7)
Aittomaki, K (7)
Chenevix-Trench, G (7)
Easton, DF (7)
Bartels, M (6)
Lindblom, A (6)
Martin, NG (6)
Hopper, JL (6)
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