| 61. |
- Ghandriz, Toheed, 1982, et al.
(författare)
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Optimization data on total cost of ownership for conventional and battery electric heavy vehicles driven by humans and by Automated Driving Systems
- 2020
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Ingår i: Data in Brief. - : Elsevier BV. - 2352-3409. ; 30
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Tidskriftsartikel (refereegranskat)abstract
- In road freight transport, the emerging technologies such as automated driving systems improve the mobility, productivity and fuel efficiency. However, the improved efficiency is not enough to meet environmental goals due to growing demands of transportation. Combining automated driving systems and electrified propulsion can substantially improve the road freight transport efficiency. However, the high cost of the battery electric heavy vehicles is a barrier hindering their adoption by the transportation companies. Automated driving systems, requiring no human driver on–board, make the battery electric heavy vehicles competitive to their conventional counterparts in a wider range of transportation tasks and use cases compared to the vehicles with human drivers. The presented data identify transportation tasks where the battery electric heavy vehicles driven by humans or by automated driving systems have lower cost of ownership than their conventional counterparts. The data were produced by optimizing the vehicle propulsion system together with the loading/unloading schemes and charging powers, with the objective of minimizing the total cost of ownership on 3072 different transportation scenarios, according to research article “Impact of automated driving systems on road freight transport and electrified propulsion of heavy vehicles” (Ghandriz et al., 2020). The data help understanding the effects of traveled distance, road hilliness and vehicle size on the total cost of ownership of the vehicles with different propulsion and driving systems. Data also include sensitivity tests on the uncertain parameters.
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| 62. |
- Ghandriz, Toheed, 1982, et al.
(författare)
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Sensitivity Analysis of Optimal Energy Management in Plug-in Hybrid Heavy Vehicles
- 2017
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Ingår i: 2017 2nd IEEE International Conference on Intelligent Transportation Engineering (ICITE). - 9781509062737 ; , s. 320-327
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Konferensbidrag (refereegranskat)abstract
- Optimal energy management strategies of hybrid vehicles are computationally expensive when considering the entire trip ahead rather than a short upcoming horizon. Considering the entire representative trip is already needed in concept design stages of the vehicle. In order to come up with an appropriate design while minimizing the total ownership cost the energy management strategies must already be used together with early concept evaluations. To investigate the possibility of replacing the optimal energy management with simpler approaches, here, the sensitivity of optimal solution to some of vehicle parameters and traffic flow is studied. It is seen that a simpler approach, i.e. an instantaneous optimization, can be used, in case of smooth traffic flow, since the gain of optimal strategy in reduction of operational cost is less than 4% for different vehicle hardware setup and for selected representative driving cycle. Dynamic programming is used as a solution method for finding the optimal strategy.
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| 63. |
- Ghandriz, Toheed, 1982, et al.
(författare)
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Transportation-mission-based Optimization of Heterogeneous Heavy-vehicle Fleet Including Electrified Propulsion
- 2021
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Ingår i: Energies. - : MDPI AG. - 1996-1073 .- 1996-1073. ; 14:11
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Tidskriftsartikel (refereegranskat)abstract
- Commercial-vehicle manufacturers design vehicles to operate over a wide range of transportation tasks and driving cycles. However, certain possibilities of reducing emissions, manufacturing and operational costs from end vehicles are neglected if the target range of transportation tasks is narrow and known in advance, especially in case of electrified propulsion. Apart from real-time energy optimization, vehicle hardware can be meticulously tailored to best fit a known transportation task. As proposed in this study, a heterogeneous fleet of heavy-vehicles can be designed in a more cost- and energy-efficient manner, if the coupling between vehicle hardware, transportation mission, and infrastructure is considered during initial conceptual-design stages. To this end, a rather large optimization problem was defined and solved to minimize the total cost of fleet ownership in an integrated manner for a real-world case study. In the said case-study, design variables of optimization problem included mission, recharging infrastructure, loading--unloading scheme, number of vehicles of each type, number of trips, vehicle-loading capacity, selection between conventional, fully electric, and hybrid powertrains, size of internal-combustion engines and electric motors, number of axles being powered, and type and size of battery packs. This study demonstrated that by means of integrated fleet customization, battery-electric heavy-vehicles could strongly compete against their conventional combustion-powered counterparts. Primary focus has been put on optimizing vehicle propulsion, transport mission, infrastructure and fleet size rather than routing.
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| 64. |
- Hellgren, Jonas, 1974, et al.
(författare)
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A Systematic Way of Choosing Driveline Confriguration and Sizing Components in Hybrid Vehicles
- 2000
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Ingår i: 2000 Future Transportation Technology Conference, August 21-23, 2000, in Costa Mesa, California, USA, 2000.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Energy saving in general and less polluting vehicles in specific, become more and more urgent topics. One reason is that, in a world where the demand for fast transportation is increasing, the risk of global warming is a fact. Hybrid Vehicles (HV:s) are proposed as a more environmentally friendly candidate than conventional vehicles. Nowadays, there are numerous different types of HV:s and the components can, in theory, be sized in infinite ways. There is no simple answer to how to choose driveline configuration and size components in a HV. This paper describes one method, Driveline Synthesis (DS), that systematically presents a suitable driveline, on the basis of demands and conditions. Examples of demands are driving cycle and emission free zones. Some conditions are fuel price, tax on pollution and discount rate. The most suitable driveline is defined as the most cost effective. Total cost is defined as the sum of: cost of components, fuel cost, cost of external energy and cost of pollution. Genetic algorithms are used as an optimization method.Two major types of drivelines are compared in a case study, a conventional bus with a diesel engine and automatic transmission versus a series hybrid bus with different types of primary power units (diesel engine or fuel cell) and storage devices (super capacitor or NiMH battery). DS gives reasonable answers but needs further validation and development. One conclusion from the work is that the most suitable driveline configuration depends very much on demands, conditions and present technology, i.e. HV:s are only preferable to conventional vehicles under special circumstances.
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| 65. |
- Hellgren, K., et al.
(författare)
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Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers
- 2017
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:1, s. 105-111
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Tidskriftsartikel (refereegranskat)abstract
- Background Safety data on cancer risks following tumour necrosis factor alpha inhibitors (TNFi) in patients with spondyloarthritis (SpA) (here defined as ankylosing spondylitis (AS), undifferentiated spondarthropaties (SpA UNS), psoriatic arthritis (PsA)) are scarce. Our objective was to assess risks for cancer overall and for common subtypes in patients with SpA treated with TNFi compared with TNFi-naive patients with SpA and to the general population. Methods From the Swedish (Anti-Rheumatic Therapy in Sweden (ARTIS)) and Danish (DANBIO) biologics registers, we assembled 8703 (ARTIS=5448, DANBIO=3255) patients with SpA initiating a first TNFi 2001-2011. From the Swedish National Patient and Population Registers we assembled a TNFi-naive SpA cohort (n=28,164) and a Swedish age-matched and sex-matched general population comparator cohort (n=131 687). We identified incident cancers by linkage with the nationwide Swedish and Danish Cancer Registers 2001-2011, and calculated age-standardised and sex-standardised incidence ratios as measures of relative risk (RR). Results Based on 1188 cancers among the TNFi-naive patients with SpA, RR of cancer overall was 1.1 (95% Cl 1.0 to 1.2). Based on 147 cancers among TNFi initiators with SpA, RR versus TNFi-naive was 0.8 (95% CI 0.7 to 1.0) and results were similar for AS and PsA when analysed separately. Site-specific cancer RRs: prostate 0.5 (95% CI 0.3 to 0.8), lung 0.6 (95% CI 0.3 to 1.3), colorectal 1.0 (95% CI 0.5 to 2.0), breast 1.3 (95% Cl 0.9 to 2.0), lymphoma 0.8 (95% CI 0.4 to 1.8) and melanoma 1.4 (95% CI 0.7 to 2.6). Conclusions In patients with SpA, treatment with TNFi was not associated with increased risks of cancer, neither overall nor for the six most common cancer types.
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| 66. |
- Hellgren, Margareta, 1955, et al.
(författare)
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Feasibility of a randomized controlled intervention with physical activity in participants with impaired glucose tolerance recruited by FINDRISC: A pilot study
- 2014
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Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 42:5, s. 463-470
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Tidskriftsartikel (refereegranskat)abstract
- Background: This study aimed to explore the feasibility and effect of an intervention in clinical practice with isolated physical activity in individuals with IGT, recruited by the FINDRISC questionnaire. Methods: The questionnaire was sent to a population of 9734 individuals, 35-75 years old, in Sweden. Those with a risk score >= 15 were encouraged to perform an oral glucose tolerance test. Individuals with IGT were invited to participate in a randomized controlled trial with a focus on physical activity. The participants were allocated to one of three arms; basic intervention, intensive intervention or to care as usual. A total of 52 individuals were carefully examined and questionnaires about diet and lifestyle were completed at baseline and after one year. All analyses were adjusted for differences in age and sex, and calorie intake when relevant. Results: The prevalence of chronic diseases in the study population was high, creating considerable difficulties in conducting a standardized test for fitness. Waist circumference (p=0.020), sagittal diameter (p=0.035), body weight (p=0.038) and BMI (p=0.043) decreased significantly more in the intensive care group than in care as usual and the basic care group. However, the significance was abolished when differences in energy intake were accounted for. Conclusions: In an intention to treat, prospective lifestyle interventions with physical activity are feasible, but a high prevalence of comorbidities needs to be considered. Also, an intervention focused on isolated physical activity inevitably led to changes in diet with weight loss and significant improvement of essential risk factors in spite of the participants' burden of chronic diseases.
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| 67. |
- Hellgren, Margareta, 1955, et al.
(författare)
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Haemoglobin A1c as a screening tool for type 2 diabetes and prediabetes in populations of Swedish and Middle-East ancestry
- 2017
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Ingår i: Primary Care Diabetes. - : Elsevier BV. - 1751-9918 .- 1878-0210. ; 60, s. S148-S148
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To explore and compare sensitivity and specificity for HbA1c >= 48 mmol/mol as a predictor for type 2 diabetes mellitus (T2DM) in two populations with different ethnicity and to examine the predictive value of two levels of HbA1c (>= 42 mmol/mol, >= 39 mmol/mol) for prediabetes in these populations. Methods: Four cohorts were examined with an oral glucose tolerance test. (1) The MEDIM Study (n = 1991 individuals of Swedish and Iraqi ancestry); (2) The Skaraborg Project (n=1327 individuals of Swedish ancestry); (3) The 4-D study (n=424 individuals of Swedish, Iraqi and Turkish ancestry); (4) The Flemingsberg study (n = 212 participants of Turkish ancestry). Results: HbA1c >= 48 mmol/mol had a sensitivity for T2DM of 31% and 25% respectively in individuals of Middle-East and Swedish ancestry. The positive and negative predictive value was high in both populations (70.3, 96.4 and 96.2, 97.6 respectively). Using HbA1c >= 42 mmol/mol and >= 39 mmol/mol as a predictor for prediabetes gave a sensitivity of 17% and 36% in individuals of Middle-East and 15% and 34% in individuals of Swedish ancestry. Conclusions: Even if HbA1c >= 48 mmol/mol is a valuable diagnostic tool, it is a blunt and insensitive tool for screening and would exclude most people with T2DM, independent of ancestry and age. HbA1c is an inefficient way to detect individuals with prediabetes. (C) 2017 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
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| 68. |
- Hellström, Ann, 1959, et al.
(författare)
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Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm Infants
- 2020
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 12:7
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Tidskriftsartikel (refereegranskat)abstract
- Fetal and early postnatal inflammation have been associated with increased morbidity in extremely preterm infants. This study aimed to demonstrate if postpartum levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) were associated with early inflammation. In a cohort of 90 extremely preterm infants, DHA and AA in cord blood, on the first postnatal day and on postnatal day 7 were examined in relation to early systemic inflammation, defined as elevated C-reactive protein (CRP) and/or interleukin-6 (IL-6) within 72 h from birth, with or without positive blood culture. Median serum level of DHA was 0.5 mol% (95% CI (confidence interval) 0.2-0.9,P= 0.006) lower than the first postnatal day in infants with early systemic inflammation, compared to infants without signs of inflammation, whereas levels of AA were not statistically different between infants with and without signs of inflammation. In cord blood, lower serum levels of both DHA (correlation coefficient -0.40;P= 0.010) and AA (correlation coefficient -0.54;p< 0.001) correlated with higher levels of IL-6. Levels of DHA or AA did not differ between infants with and without histological signs of chorioamnionitis or fetal inflammation. In conclusion, serum levels of DHA at birth were associated with the inflammatory response during the early postnatal period in extremely preterm infants.
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| 69. |
- Hellström, Ann, 1959, et al.
(författare)
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Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity A Randomized Clinical Trial
- 2021
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Ingår i: JAMA Pediatrics. - : American Medical Association (AMA). - 2168-6203 .- 2168-6211. ; 175:4, s. 359-367
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Lack of arachidonic acid (AA) and docosahexaenoic acid (DHA) after extremely preterm birth may contribute to preterm morbidity, including retinopathy of prematurity (ROP). OBJECTIVE To determine whether enteral supplementation with fatty acids from birth to 40 weeks' postmenstrual age reduces ROP in extremely preterm infants. DESIGN, SETTING, AND PARTICIPANTS The Mega Donna Mega trial, a randomized clinical trial, was a multicenter study performed at 3 university hospitals in Sweden from December 15, 2016, to December 15, 2019. The screening pediatric ophthalmologists were masked to patient groupings. A total of 209 infants born at less than 27 weeks' gestation were tested for eligibility, and 206 infants were included. Efficacy analyses were performed on as-randomized groups on the intention-to-treat population and on the per-protocol population using as-treated groups. Statistical analyses were performed from February to April 2020. INTERVENTIONS Infants received either supplementation with an enteral oil providing AA (100mg/kg/d) and DHA (50mg/kg/d) (AA:DHA group) or no supplementation within 3 days after birth until 40 weeks' postmenstrual age. MAIN OUTCOMES AND MEASURES The primary outcomewas severe ROP (stage 3 and/or type 1). The secondary outcomes were AA and DHA serum levels and rates of other complications of preterm birth. RESULTS A total of 101 infants (58 boys [57.4%]; mean [SD] gestational age, 25.5 [1.5] weeks) were included in the AA:DHA group, and 105 infants (59 boys [56.2%]; mean [SD] gestational age, 25.5 [1.4] weeks) were included in the control group. Treatment with AA and DHA reduced severe ROP compared with the standard of care (16 of 101 [15.8%] in the AA:DHA group vs 35 of 105 [33.3%] in the control group; adjusted relative risk, 0.50 [95% CI, 0.28-0.91]; P =.02). The AA:DHA group had significantly higher fractions of AA and DHA in serum phospholipids compared with controls (overall mean difference in AA:DHA group, 0.82 mol% [95% CI, 0.46-1.18 mol%]; P <.001; overall mean difference in control group, 0.13 mol% [95% CI, 0.01-0.24 mol%]; P =.03). There were no significant differences between the AA:DHA group and the control group in the rates of bronchopulmonary dysplasia (48 of 101 [47.5%] vs 48 of 105 [45.7%]) and of any grade of intraventricular hemorrhage (43 of 101 [42.6%] vs 42 of 105 [40.0%]). In the AA:DHA group and control group, respectively, sepsis occurred in 42 of 101 infants (41.6%) and 53 of 105 infants (50.5%), serious adverse events occurred in 26 of 101 infants (25.7%) and 26 of 105 infants (24.8%), and 16 of 101 infants (15.8%) and 13 of 106 infants (12.3%) died. CONCLUSIONS AND RELEVANCE This study found that, compared with standard of care, enteral AA:DHA supplementation lowered the risk of severe ROP by 50% and showed overall higher serum levels of both AA and DHA. Enteral lipid supplementation with AA:DHA is a novel preventive strategy to decrease severe ROP in extremely preterm infants.
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| 70. |
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