| 61. |
- Abbasi, R., et al.
(författare)
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Observation of anisotropy in the galactic cosmic-ray arrival directions at 400 TeV with IceCube
- 2012
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 746:1, s. 33-
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we report the first observation in the Southern hemisphere of an energy dependence in the Galactic cosmic-ray anisotropy up to a few hundred TeV. This measurement was performed using cosmic-ray-induced muons recorded by the partially deployed IceCube observatory between 2009 May and 2010 May. The data include a total of 33 x 10(9) muon events with a median angular resolution of similar to 3 degrees. A sky map of the relative intensity in arrival direction over the Southern celestial sky is presented for cosmic-ray median energies of 20 and 400 TeV. The same large-scale anisotropy observed at median energies around 20 TeV is not present at 400 TeV. Instead, the high-energy sky map shows a different anisotropy structure including a deficit with a post-trial significance of -6.3 sigma. This anisotropy reveals a new feature of the Galactic cosmic-ray distribution, which must be incorporated into theories of the origin and propagation of cosmic rays.
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| 62. |
- Abbasi, R., et al.
(författare)
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Search for relativistic magnetic monopoles with IceCube
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 87:2, s. 022001-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first results in the search for relativistic magnetic monopoles with the IceCube detector, a subsurface neutrino telescope located in the South Polar ice cap containing a volume of 1 km(3). This analysis searches data taken on the partially completed detector during 2007 when roughly 0.2 km(3) of ice was instrumented. The lack of candidate events leads to an upper limit on the flux of relativistic magnetic monopoles of Phi(90%C.L.) similar to 3 x 10(-18) cm(-2) sr(-1) s(-1) for beta >= 0.8. This is a factor of 4 improvement over the previous best experimental flux limits up to a Lorentz boost gamma below 10(7). This result is then interpreted for a wide range of mass and kinetic energy values.
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| 63. |
- Abbasi, R., et al.
(författare)
-
Search for ultrahigh-energy tau neutrinos with IceCube
- 2012
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:2, s. 022005-
-
Tidskriftsartikel (refereegranskat)abstract
- The first dedicated search for ultrahigh-energy (UHE) tau neutrinos of astrophysical origin was performed using the IceCube detector in its 22-string configuration with an instrumented volume of roughly 0: 25 km(3). The search also had sensitivity to UHE electron and muon neutrinos. After application of all selection criteria to approximately 200 live-days of data, we expect a background of 0.60 +/- 0.19(stat)(-0.58)(+0.56)(syst) events and observe three events, which after inspection, emerge as being compatible with background but are kept in the final sample. Therefore, we set an upper limit on neutrinos of all flavors from UHE astrophysical sources at 90% C.L. of E-v(2)Phi(90)(v(x)) < 16.3 x 10(-8) GeV cm(-2) sr(-1) s(-1) over an estimated primary neutrino energy range of 340 TeV to 200 PeV.
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| 64. |
- Abbasi, R., et al.
(författare)
-
Searches for high-energy neutrino emission in the galaxy with the combined icecube-amanda detector
- 2013
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 763:1, s. 33-
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Tidskriftsartikel (refereegranskat)abstract
- We report on searches for neutrino sources at energies above 200 GeV in the Northern sky of the Galactic plane, using the data collected by the South Pole neutrino telescope, IceCube, and AMANDA. The Galactic region considered in this work includes the local arm toward the Cygnus region and our closest approach to the Perseus Arm. The searches are based on the data collected between 2007 and 2009. During this time AMANDA was an integrated part of IceCube, which was still under construction and operated with 22 strings (2007-2008) and 40 strings (2008-2009) of optical modules deployed in the ice. By combining the advantages of the larger IceCube detector with the lower energy threshold of the more compact AMANDA detector, we obtain an improved sensitivity at energies below ∼10 TeV with respect to previous searches. The analyses presented here are a scan for point sources within the Galactic plane, a search optimized for multiple and extended sources in the Cygnus region, which might be below the sensitivity of the point source scan, and studies of seven pre-selected neutrino source candidates. For one of them, Cygnus X-3, a time-dependent search for neutrino emission in coincidence with observed radio and X-ray flares has been performed. No evidence of a signal is found, and upper limits are reported for each of the searches. We investigate neutrino spectra proportional to E -2 and E -3 in order to cover the entire range of possible neutrino spectra. The steeply falling E -3 neutrino spectrum can also be used to approximate neutrino energy spectra with energy cutoffs below 50 TeV since these result in a similar energy distribution of events in the detector. For the region of the Galactic plane visible in the Northern sky, the 90% confidence level muon neutrino flux upper limits are in the range E 3 dN/dE ∼ 5.4-19.5 × 10-11 TeV2 cm-2 s-1 for point-like neutrino sources in the energy region [180.0 GeV-20.5 TeV]. These represent the most stringent upper limits for soft-spectra neutrino sources within the Galaxy reported to date.
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| 65. |
- Abbasi, R., et al.
(författare)
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Searches for periodic neutrino emission from binary systems with 22 and 40 strings of IceCube
- 2012
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 748:2, s. 118-
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we present the results of searches for periodic neutrino emission from a catalog of binary systems. Such modulation, observed in the photon flux, would be caused by the geometry of these systems. In the analysis, the period is fixed by these photon observations, while the phase and duration of the neutrino emission are treated as free parameters to be fit with the data. If the emission occurs during similar to 20% or less of the total period, this analysis achieves better sensitivity than a time-integrated analysis. We use the IceCube data taken from 2007 May 31 to 2008 April 5 with its 22 string configuration and from 2008 April 5 to 2009 May 20 with its 40 string configuration. No evidence for neutrino emission is found, with the strongest excess occurring for Cygnus X-3 at 2.1 sigma significance after accounting for trials. Neutrino flux upper limits for both periodic and time-integrated emission are provided.
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| 66. |
- Abbasi, R., et al.
(författare)
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Searching for soft relativistic jets in core-collapse supernovae with the IceCube optical follow-up program
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 539, s. A60-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Transient neutrino sources such as gamma-ray bursts (GRBs) and supernovae (SNe) are hypothesized to emit bursts of high-energy neutrinos on a time-scale of less than or similar to 100 s. While GRB neutrinos would be produced in high relativistic jets, core-collapse SNe might host soft-relativistic jets, which become stalled in the outer layers of the progenitor star leading to an efficient production of high-energy neutrinos. Aims. To increase the sensitivity to these neutrinos and identify their sources, a low-threshold optical follow-up program for neutrino multiplets detected with the IceCube observatory has been implemented. Methods. If a neutrino multiplet, i.e. two or more neutrinos from the same direction within 100 s, is found by IceCube a trigger is sent to the Robotic Optical Transient Search Experiment, ROTSE. The 4 ROTSE telescopes immediately start an observation program of the corresponding region of the sky in order to detect an optical counterpart to the neutrino events. Results. No statistically significant excess in the rate of neutrino multiplets has been observed and furthermore no coincidence with an optical counterpart was found. Conclusions. The search allows, for the first time, to set stringent limits on current models predicting a high-energy neutrino flux from soft relativistic hadronic jets in core-collapse SNe. We conclude that a sub-population of SNe with typical Lorentz boost factor and jet energy of 10 and 3 x 1051 erg, respectively, does not exceed 4.2% at 90% confidence.
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| 67. |
- Abbasi, R., et al.
(författare)
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The design and performance of IceCube DeepCore
- 2012
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 35:10, s. 615-624
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Tidskriftsartikel (refereegranskat)abstract
- The IceCube neutrino observatory in operation at the South Pole, Antarctica, comprises three distinct components: a large buried array for ultrahigh energy neutrino detection, a surface air shower array, and a new buried component called DeepCore. DeepCore was designed to lower the IceCube neutrino energy threshold by over an order of magnitude, to energies as low as about 10 GeV. DeepCore is situated primarily 2100 m below the surface of the icecap at the South Pole, at the bottom center of the existing IceCube array, and began taking physics data in May 2010. Its location takes advantage of the exceptionally clear ice at those depths and allows it to use the surrounding IceCube detector as a highly efficient active veto against the principal background of downward-going muons produced in cosmic-ray air showers. DeepCore has a module density roughly five times higher than that of the standard IceCube array, and uses photomultiplier tubes with a new photocathode featuring a quantum efficiency about 35% higher than standard IceCube PMTs. Taken together, these features of DeepCore will increase IceCube's sensitivity to neutrinos from WIMP dark matter annihilations, atmospheric neutrino oscillations, galactic supernova neutrinos, and point sources of neutrinos in the northern and southern skies. In this paper we describe the design and initial performance of DeepCore.
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| 68. |
- Adrian-Martinez, S., et al.
(författare)
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The First Combined Search For Neutrino Point-Sources In The Southern Hemisphere With The Antares And Icecube Neutrino Telescopes
- 2016
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 823:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present the results of searches for point-like sources of neutrinos based on the first combined analysis of data from both the ANTARES and IceCube neutrino telescopes. The combination of both detectors, which differ in size and location, forms a window in the southern sky where the sensitivity to point sources improves by up to a factor of 2 compared with individual analyses. Using data recorded by ANTARES from 2007 to 2012, and by IceCube from 2008 to 2011, we search for sources of neutrino emission both across the southern sky and from a preselected list of candidate objects. No significant excess over background has been found in these searches, and flux upper limits for the candidate sources are presented for E-2.5 and E-2 power-law spectra with different energy cut-offs.
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| 69. |
- Amare, Azmeraw, et al.
(författare)
-
Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
- 2023
-
Ingår i: Research square. - : Research Square Platform LLC.
-
Tidskriftsartikel (refereegranskat)abstract
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������.
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| 70. |
- Amare, Azmeraw T, et al.
(författare)
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Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.
- 2023
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Ingår i: Molecular psychiatry. - 1476-5578.
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Tidskriftsartikel (refereegranskat)abstract
- Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P < 0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P = 9.8 × 10-12, R2 = 1.9%) and continuous (P = 6.4 × 10-9, R2 = 2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P = 3.9 × 10-4, R2 = 0.9%), but not for the continuous outcome (P = 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.
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