| 51. |
- Gazinska, Patrycja, et al.
(författare)
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Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles
- 2013
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Ingår i: Modern Pathology. - : Elsevier BV. - 0893-3952 .- 1530-0285. ; 26:7, s. 955-966
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Tidskriftsartikel (refereegranskat)abstract
- Basal-like invasive breast cancer is an important clinical group because of its association with a triple-negative phenotype defined by the lack of expression of estrogen, progesterone and human epidermal growth factor receptors 2, relative lack of therapeutic options and poor prognosis. However, depending on the method used to define these lesions, morphological assessment, immunohistochemical markers or gene expression, a different set of tumors is captured. The aim of this study was to investigate the consequences of using different methodological approaches to define basal-like lesions among triple-negative breast carcinomas with regard to their clinicopathological features and patient outcome. The cohort consisted of 142 invasive breast cancers with a triple-negative receptor status. First, each was reviewed histologically and those with morphological basal-like features were characterized as 'Path-Basal'. Second, the 'Core Basal' immunohistochemical lesions, defined as cytokeratin 5/6 and/or epidermal growth factor receptor 1 positive, within the triple-negative breast cancers were identified, and third their classification based on gene expression profiling was retrieved and those in the molecular 'PAM50 basal-like' subtype recorded. A total of 116 basal-like breast cancers were identified among the 142 triple-negative breast cancers by at least one of these three classifications (80%), but only 13 samples were defined as basal-like with all three methods. None of these 13 tumors were associated with lymphovascular invasion. The 34 morphological 'Path-Basal' lesions were significantly associated with a lack of nodal metastases. Comparing the estimates of death in the three classifications, the highest risk of death was seen for the 'Core Basal' group. In this study, we highlight that the definition of basal-like breast cancer based on different methodologies varies significantly and does not identify the same lesions. This incomplete overlap of cases emphasizes the need for consistent or new approaches to improve precise identification.
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| 53. |
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| 54. |
- Hagfeldt, A., et al.
(författare)
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A system approach to molecular solar cells
- 2004
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Ingår i: Coordination chemistry reviews. - : Elsevier BV. - 0010-8545 .- 1873-3840. ; 248:13-14, s. 1501-1509
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Forskningsöversikt (refereegranskat)abstract
- This paper gives an overview of the research and development of dye-sensitized solar cells (DSC) within the Swedish research program 'Angstrom Solar Center'. A path towards low production cost is the development of a continuous process, which allows the production of solar cells in large volumes and with a high productivity. We have developed a deposition method for the production of the mesoporous TiO2, electrode layer that is based on compression of a powder film at room temperature. This technique allows us to use flexible substrates-a prerequisite fora continuous process. A novel interconnect technology, compatible with a continuous production process, is described. Stability data of plastic DSC, exposed to indoor light for more than 10,000 h, demonstrates the possibility for the technology to be explored for various types of indoor applications. Optimization of the DSC is a challenging task as it is a complex highly interacting molecular system. A system approach is proposed, where the complete DSC is investigated with a series of measurement techniques ('toolbox') that allows the study of the internal processes under relevant conditions. Two examples of such techniques are given.
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| 55. |
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| 56. |
- Hertz, E., et al.
(författare)
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First Clinicogenetic Description of Parkinson's Disease Related to GBA Mutation S107L
- 2019
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Ingår i: Movement Disorders Clinical Practice. - : Wiley. - 2330-1619. ; 6:3, s. 254-258
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Tidskriftsartikel (refereegranskat)abstract
- Background Mutations in the glucocerebrosidase gene (GBA) are a common genetic risk factor for Parkinson's disease (PD). Mutations in the N-terminus part of GBA are less commonly found in association with PD than those in the C-terminus. Phenotypic characterization of GBA-related PD has been challenging, in part attributed to differential impact of distinct GBA mutations. Aim To provide a phenotypic description of two patients with PD heterozygous for the GBA mutation S107L. The S107L mutation is located in the catalytic domain of glucocerebrosidase and has not previously been reported in patients with PD. Methods Motor and nonmotor symptoms (NMS) of PD were evaluated using established rating scales and questionnaires. The genotype was determined by Sanger sequencing. Results Two half-brothers, both heterozygous carriers of S107L, exhibited an early PD onset with several NMS. Conclusions In these patients, heterozygosity for S107L was associated with an early onset of PD with NMS.
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