| 421. |
- Yi-Ting, Lin, et al.
(författare)
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Global Plasma Metabolomics to Identify Potential Biomarkers of Blood Pressure Progression.
- 2020
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Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - : Lippincott Williams & Wilkins. - 1079-5642 .- 1524-4636. ; 40:8, s. e227-e237
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The pathophysiology of hypertension remains incompletely understood. We investigated associations of circulating metabolites with longitudinal blood pressure (BP) changes in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort and validated the findings in the Uppsala Longitudinal Study of Adult Men cohort. Approach and Results: Circulating metabolite levels were assessed with liquid- and gas-chromatography coupled to mass spectrometry among persons without BP-lowering medication at baseline. We studied associations of baseline levels of metabolites with changes in BP levels and the clinical BP stage between baseline and a follow-up examination 5 years later. In the discovery cohort, we investigated 504 individuals that contributed with 757 observations of paired BP measurements. The mean baseline systolic and diastolic BPs were 144 (19.7)/76 (9.7) mm Hg, and change in systolic and diastolic BPs were 3.7 (15.8)/-0.5 (8.6) mm Hg over 5 years. The metabolites associated with diastolic BP change were ceramide, triacylglycerol, total glycerolipids, oleic acid, and cholesterylester. No associations with longitudinal changes in systolic BP or BP stage were observed. Metabolites with similar structures to the 5 top findings in the discovery cohort were investigated in the validation cohort. Diacylglycerol (36:2) and monoacylglycerol (18:0), 2 glycerolipids, were associated with diastolic BP change in the validation cohort.CONCLUSIONS: Circulating baseline levels of ceramide, triacylglycerol, total glycerolipids, and oleic acid were positively associated with longitudinal diastolic BP change, whereas cholesterylester levels were inversely associated with longitudinal diastolic BP change. Two glycerolipids were validated in an independent cohort. These metabolites may point towards pathophysiological pathways of hypertension.
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| 422. |
- Yi-Ting, Lin, et al.
(författare)
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Proteomic Analysis of Longitudinal Changes in Blood Pressure
- 2019
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:10
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Tidskriftsartikel (refereegranskat)abstract
- Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline circulating protein levels assessed with a proximity extension assay and BP stage progression at follow-up 5 years later among persons without BP-lowering drugs at baseline in two independent community-based cohorts from the Prospective Investigation of the Vasculature in Uppsala Seniors study (PIVUS) and the Uppsala Longitudinal Study of Adult Men (ULSAM). We used an independent cohort, the Malmö Diet and Cancer Study (MDC), for replication. The primary outcome of BP stage progression was defined as per the 2017 AHA/ACC (American Heart Association/ American College of Cardiology) Guideline BP categories. We also investigated associations of protein levels with changes in BP on a continuous scale, and meta-analyzed all three cohorts. Levels of renin were associated with BP stage progression with a 5% false discovery rate (FDR) in the ULSAM (n = 238) and PIVUS (n = 566) cohorts, but we could not replicate this association in the MDC cohort (n = 2659). The association in the discovery cohorts was modest, with an odds ratio for BP stage progression over 5 years of 1.33 (95% confidence interval 1.14 to 1.56) per standard deviation of baseline renin. In conclusion, we could not find any novel robust associations with longitudinal BP increase in a proximity extension assay-based proteomics investigation in three cohorts.
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| 423. |
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| 424. |
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| 425. |
- Zadegan, Farrokh Ghani, et al.
(författare)
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A Study of Instrument Reuse and Retargeting in P1687
- 2011
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Ingår i: <em>IEEE Twelfth Workshop on RTL and High Level Testing (WRTLT 2011), MNIT Jaipur, India, November 25-26, 2011.</em>.
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Konferensbidrag (refereegranskat)abstract
- Modern chips may contain a large number of embedded test, debug, configuration, and monitoring features, called instruments. An instrument and its instrument data, instrument access procedures, may be pre-developed and reused and instruments may be accessed in different ways through the life-time of the chip, which requires retargeting. To address instruments reuse and retargeting, IEEE P1678 specifies a hardware architecture, a hardware description language, and an access procedure description language. In this paper, we investigate how P1687 facilitates instrument access procedure reuse and retargeting.
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| 426. |
- Zadegan, Farrokh Ghani, et al.
(författare)
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Automated Design for IEEE P1687
- 2011
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Ingår i: <em>The 11th Swedish System-on-Chip Conference, Varberg, Sweden, May 2-3, 2011.</em>.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 427. |
- Zadegan, Farrokh Ghani, et al.
(författare)
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Design Automation for IEEE P1687
- 2011
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Ingår i: Proceedings -Design, Automation and Test in Europe, DATE. - : IEEE. - 9781612842080 ; , s. 1-6
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Konferensbidrag (refereegranskat)abstract
- The IEEE P1687 (IJTAG) standard proposal aimsat standardizing the access to embedded test and debug logic(instruments) via the JTAG TAP. P1687 specifies a componentcalled Segment Insertion Bit (SIB) which makes it possible toconstruct a multitude of alternative P1687 instrument accessnetworks for a given set of instruments. Finding the best accessnetwork with respect to instrument access time and the numberof SIBs is a time-consuming task in the absence of EDA support.This paper is the first to describe a P1687 design automationtool which constructs and optimizes P1687 networks. Our EDAtool, called PACT, considers the concurrent and sequential accessschedule types, and is demonstrated in experiments on industrialSOCs, reporting total access time and average access time.
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| 428. |
- Zadegan, Farrokh Ghani, et al.
(författare)
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Test Scheduling in an IEEE P1687 Environment with Resource and Power Constraints
- 2011
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Ingår i: Proceedings of the Asian Test Symposium. - : IEEE. - 9781457719844 ; , s. 525-531
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Konferensbidrag (refereegranskat)abstract
- In contrast to IEEE 1149.1, IEEE P1687 allows, through segment insertion bits, flexible scan paths for accessing on-chip instruments, such as test, debug, monitoring, measurement and configuration features. Flexible access to embedded instruments allows test time reduction, which is important at production test. However, the test access scheme should be carefully selected such that resource constraints are not violated and power constraints are met. For IEEE P1687, we detail in this paper session-based and session-less test scheduling, and propose resource and power-aware test scheduling algorithms for the detailed scheduling types. Results using the implementation of our algorithms shows on ITC’02-based benchmarks significant test time reductions when compared to non-optimized test schedules.
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| 429. |
- Zadegan, Farrokh Ghani, et al.
(författare)
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Test Time Analysis for IEEE P1687
- 2010
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Ingår i: <em>Proceedings of the Asian Test Symposium</em>. - 9780769542485 ; , s. 455-460
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Konferensbidrag (refereegranskat)abstract
- The IEEE P1687 (IJTAG) standard proposal aims at providing a standardized interface between on-chip embedded logic (instruments), such as scan-chains and temperature sensors, and the IEEE 1149.1 standard which provides test data transport and test protocol for board test. A key feature in P1687 is to include Select Instrument Bits (SIBs) in the scan path to allow flexibility in test architecture design and test scheduling. This paper presents algorithms to compute the test time in a P1687 context. The algorithms are based on analysis for flat and hierarchical test architectures, considering two test schedule types - concurrent and sequential test scheduling. Furthermore, two types of overhead are identified, i.e. control data overhead and JTAG protocol overhead. The algorithms are implemented and employed in experiments on realistic industrial designs.
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| 430. |
- Zanetti, Daniela, et al.
(författare)
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Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease Addressing the Barker Hypothesis With Mendelian Randomization
- 2018
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Ingår i: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 2574-8300. ; 11:6
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower birthweight is causal for these diseases, but causality is difficult to infer from observational studies. METHODS: We performed regression analyses to assess associations of birthweight with cardiovascular disease and T2D in 237 631 individuals from the UK Biobank. Further, we assessed the causal relationship of such associations using Mendelian randomization. RESULTS: In the observational analyses, birthweight showed inverse associations with systolic and diastolic blood pressure (beta, -0.83 and -0.26; per raw unit in outcomes and SD change in birthweight; 95% confidence interval [CI], -0.90 to -0.75 and -0.31 to -0.22, respectively), T2D (odds ratio, 0.83; 95% CI, 0.79-0.87), lipid-lowering treatment (odds ratio, 0.84; 95% CI, 0.81-0.86), and coronary artery disease (hazard ratio, 0.85; 95% CI, 0.78-0.94), whereas the associations with adult body mass index and body fat (beta, 0.04 and 0.02; per SD change in outcomes and birthweight; 95% CI, 0.03-0.04 and 0.01-0.02, respectively) were positive. The Mendelian randomization analyses indicated inverse causal associations of birthweight with low-density lipoprotein cholesterol, 2-hour glucose, coronary artery disease, and T2D and positive causal association with body mass index but no associations with blood pressure. CONCLUSIONS: Our study indicates that lower birthweight, used as a proxy for intrauterine growth retardation, is causally related with increased susceptibility to coronary artery disease and T2D. This causal relationship is not mediated by adult obesity or hypertension.
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