SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Isaacs William) "

Sökning: WFRF:(Isaacs William)

  • Resultat 51-51 av 51
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
51.
  • Zheng, S. Lilly, et al. (författare)
  • Genetic variants and family history predict prostate cancer similar to prostate-specific antigen
  • 2009
  • Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 15:3, s. 1105-1111
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Although prostate-specific antigen (PSA) is the best biomarker for predicting prostate cancer, its predictive performance needs to be improved. Results from the Prostate Cancer Prevention Trial revealed the overall performance measured by the areas under curve of the receiver operating characteristic at 0.68. The goal of the present study is to assess the ability of genetic variants as a PSA-independent method to predict prostate cancer risk. EXPERIMENTAL DESIGN: We systematically evaluated all prostate cancer risk variants that were identified from genome-wide association studies during the past year in a large population-based prostate cancer case-control study population in Sweden, including 2,893 prostate cancer patients and 1,781 men without prostate cancer. RESULTS: Twelve single nucleotide polymorphisms were independently associated with prostate cancer risk in this Swedish study population. Using a cutoff of any 11 risk alleles or family history, the sensitivity and specificity for predicting prostate cancer were 0.25 and 0.86, respectively. The overall predictive performance of prostate cancer using genetic variants, family history, and age, measured by areas under curve was 0.65 (95% confidence interval, 0.63-0.66), significantly improved over that of family history and age (0.61%; 95% confidence interval, 0.59-0.62; P = 2.3 x 10(-10)). CONCLUSION: The predictive performance for prostate cancer using genetic variants and family history is similar to that of PSA. The utility of genetic testing, alone and in combination with PSA levels, should be evaluated in large studies such as the European Randomized Study for Prostate Cancer trial and Prostate Cancer Prevention Trial.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 51-51 av 51
Typ av publikation
tidskriftsartikel (49)
forskningsöversikt (2)
Typ av innehåll
refereegranskat (48)
övrigt vetenskapligt/konstnärligt (2)
populärvet., debatt m.m. (1)
Författare/redaktör
Xu, Jianfeng (27)
Wiklund, Fredrik (26)
Isaacs, William B (25)
Grönberg, Henrik (19)
Zheng, S Lilly (17)
Sun, Jielin (17)
visa fler...
Stattin, Pär (15)
Wiley, Kathleen E (14)
Isaacs, Sarah D (12)
Chang, Bao-li (12)
Adami, Hans Olov (10)
Hsu, Fang Chi (10)
Duggan, David (10)
Carpten, John D (10)
Walsh, Patrick C (10)
Hopper, John L. (9)
Gronberg, Henrik (9)
Foulkes, William D (9)
Giles, Graham G (8)
Isaacs, Aaron (8)
Zhu, Yi (7)
Chanock, Stephen J (7)
McCarthy, Mark I (7)
Le Marchand, Loïc (7)
Hunter, David J (7)
Hofman, Albert (7)
Whittemore, Alice S (7)
Lange, Ethan M (7)
Turner, Aubrey R (7)
Haiman, Christopher ... (6)
Schleutker, Johanna (6)
Cancel-Tassin, Geral ... (6)
Stanford, Janet L (6)
Thibodeau, Stephen N (6)
Deloukas, Panos (6)
Severi, Gianluca (6)
Kraft, Peter (6)
Easton, Douglas F. (6)
van Duijn, Cornelia ... (6)
Cooney, Kathleen A. (6)
Ostrander, Elaine A. (6)
Eeles, Ros (6)
Loos, Ruth J F (6)
Uitterlinden, André ... (6)
Hayward, Caroline (6)
Boerwinkle, Eric (6)
Schaid, Daniel J (6)
McDonnell, Shannon K (6)
Cussenot, Olivier (6)
Lindgren, Cecilia M. (6)
visa färre...
Lärosäte
Umeå universitet (31)
Karolinska Institutet (23)
Lunds universitet (14)
Uppsala universitet (7)
Mälardalens universitet (5)
Örebro universitet (4)
visa fler...
Stockholms universitet (2)
Sveriges Lantbruksuniversitet (2)
Göteborgs universitet (1)
Luleå tekniska universitet (1)
Linköpings universitet (1)
Chalmers tekniska högskola (1)
Linnéuniversitetet (1)
visa färre...
Språk
Engelska (51)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (33)
Naturvetenskap (7)
Lantbruksvetenskap (2)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy