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Sökning: WFRF:(Iversen P)

  • Resultat 141-150 av 201
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141.
  • Iversen, AKN, et al. (författare)
  • Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus
  • 2003
  • Ingår i: Journal of Infectious Diseases. - 1537-6613. ; 187:2, s. 215-225
  • Tidskriftsartikel (refereegranskat)abstract
    • The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.
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148.
  • Kharbush, Jenan J., et al. (författare)
  • Particulate Organic Carbon Deconstructed : Molecular and Chemical Composition of Particulate Organic Carbon in the Ocean
  • 2020
  • Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 7
  • Forskningsöversikt (refereegranskat)abstract
    • The dynamics of the particulate organic carbon (POC) pool in the ocean are central to the marine carbon cycle. POC is the link between surface primary production, the deep ocean, and sediments. The rate at which POC is degraded in the dark ocean can impact atmospheric CO2 concentration. Therefore, a central focus of marine organic geochemistry studies is to improve our understanding of POC distribution, composition, and cycling. The last few decades have seen improvements in analytical techniques that have greatly expanded what we can measure, both in terms of organic compound structural diversity and isotopic composition, and complementary molecular omics studies. Here we provide a brief overview of the autochthonous, allochthonous, and anthropogenic components comprising POC in the ocean. In addition, we highlight key needs for future research that will enable us to more effectively connect diverse data sources and link the identity and structural diversity of POC to its sources and transformation processes.
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150.
  • King, P.D.C., et al. (författare)
  • Large Tunable Rashba Spin Splitting of a Two-Dimensional Electron Gas in Bi2Se3
  • 2011
  • Ingår i: Physical Review Letters. - : aps physics. ; 107:9
  • Tidskriftsartikel (refereegranskat)abstract
    • We report a Rashba spin splitting of a two-dimensional electron gas in the topological insulator Bi2Se3 from angle-resolved photoemission spectroscopy. We further demonstrate its electrostatic control, and show that spin splittings can be achieved which are at least an order-of-magnitude larger than in other semiconductors. Together these results show promise for the miniaturization of spintronic devices to the nanoscale and their operation at room temperature.
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  • Resultat 141-150 av 201
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