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21.	Hivert, Marie-France, et al. (author) Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program 2011 In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 60:4, s. 1340-1348 Journal article (peer-reviewed)abstract OBJECTIVE Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested if a GRS based on an updated list of 34 type 2 diabetes-associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes Prevention Program (DPP). RESEARCH DESIGN AND METHODS We genotyped 34 type 2 diabetes-associated variants in 2,843 DPP participants at high risk of type 2 diabetes from five ethnic groups representative of the U.S. population, who had been randomized to placebo, metformin, or lifestyle intervention. We built a GRS by weighting each risk allele by its reported effect size on type 2 diabetes risk and summing these values. We tested its ability to predict diabetes incidence or regression to NGR in models adjusted for age, sex, ethnicity, waist circumference, and treatment assignment. RESULTS lit multivariate-adjusted models, the GRS was significantly associated with increased risk of progression to diabetes (hazard ratio [HR] = 1.02 per risk allele [95% CI 1.00-1.05]; P = 0.03) and a lower probability of regression to NGR (HR = 0.95 per risk allele [95% CI 0.93-0.981; P < 0.0001). At baseline, a higher GRS was associated with a lower insulinogenic index (P < 0.001), confirming an impairment in beta-cell function. We detected no significant interaction between GRS and treatment, but the lifestyle intervention was effective in the highest quartile of ORS (P < 0.0001). CONCLUSIONS A high GRS is associated with increased risk of developing diabetes and lower probability of returning to NGR in high-risk individuals, but a lifestyle intervention attenuates this risk. Diabetes 60:1340-1348, 2011
22.	Soler Artigas, María, et al. (author) Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. 2011 In: American journal of respiratory and critical care medicine. - 1535-4970. ; 184:7, s. 786-95 Journal article (peer-reviewed)abstract Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population samples, but their association with chronic obstructive pulmonary disease (COPD) has not yet been proven, nor have their combined effects on lung function and COPD been studied.

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Type of publication: journal article (22)

Type of content: peer-reviewed (22)

Author/Editor: Khaw, Kay-Tee (3); Harrington, Robert A (3); Vineis, Paolo (3); Wareham, Nicholas J. (3); McCarthy, Mark I (3); Van de Werf, Frans (3); show more...; Armstrong, Paul W. (3); Califf, Robert M. (3); Linseisen, Jakob (2); Overvad, Kim (2); Clavel-Chapelon, Fra ... (2); Boeing, Heiner (2); Krogh, Vittorio (2); Tumino, Rosario (2); Riboli, Elio (2); Franks, Paul (2); De Angelis, R (2); Heinrich, Joachim (2); Cooper, Cyrus (2); Deloukas, Panos (2); Syvänen, Ann-Christi ... (2); Ardanaz, Eva (2); Palli, Domenico (2); Panico, Salvatore (2); Kellis, Manolis (2); Navarro, Carmen (2); Bueno-de-Mesquita, H ... (2); Trichopoulos, Dimitr ... (2); Boffetta, Paolo (2); Peeters, Petra H. M. (2); Hallmans, Göran (2); Lissowska, Jolanta (2); van Duijn, Cornelia ... (2); Surakka, Ida (2); Ripatti, Samuli (2); Kähönen, Mika (2); Marchini, Jonathan (2); Nyberg, Fredrik, 196 ... (2); Albrecht, Eva (2); Karrasch, Stefan (2); Mangino, Massimo (2); Wichmann, H. Erich (2); Spector, Tim D. (2); Kaprio, Jaakko (2); Schulz, Holger (2); Brennan, Paul (2); Montalescot, Gilles (2); Olin, Anna-Carin, 19 ... (2); Tricoci, Pierluigi (2); Barroso, Ines (2); show less...

University: Uppsala University (10); Umeå University (4); Lund University (4); University of Gothenburg (3); Stockholm University (2); Karolinska Institutet (2); show more...; Royal Institute of Technology (1); University of Skövde (1); Chalmers University of Technology (1); show less...

Language: English (22)

Research subject (UKÄ/SCB): Natural sciences (8); Medical and Health Sciences (6)

Year: 2011 (22)Undo refine

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