| 571. |
- Ravi, Naveen, et al.
(författare)
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Identification of targetable lesions in anaplastic thyroid cancer by genome profiling
- 2019
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Anaplastic thyroid cancer (ATC) is a rare and extremely malignant tumor with no available cure. The genetic landscape of this malignancy has not yet been fully explored. In this study, we performed whole exome sequencing and the RNA-sequencing of fourteen cases of ATC to delineate copy number changes, fusion gene events, and somatic mutations. A high frequency of genomic amplifications was seen, including 29% of cases having amplification of CCNE1 and 9% of CDK6; these events may be targetable by cyclin dependent kinase (CDK) inhibition. Furthermore, 9% harbored amplification of TWIST1, which is also a potentially targetable lesion. A total of 21 fusion genes in five cases were seen, none of which were recurrent. Frequent mutations included TP53 (55%), the TERT promoter (36%), and ATM (27%). Analyses of mutational signatures showed an involvement of processes that are associated with normal aging, defective DNA mismatch repair, activation induced cytidine deaminase (AID)/apolipoprotein B editing complex (APOBEC) activity, failure of DNA double-strand break repair, and tobacco exposure. Taken together, our results shed new light on the tumorigenesis of ATC and show that a relatively large proportion (36%) of ATCs harbor genetic events that make them candidates for novel therapeutic approaches. When considering that ATC today has a mortality rate of close to 100%, this is highly relevant from a clinical perspective.
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| 572. |
- Reinfeldt, Sabine, 1978, et al.
(författare)
-
Long-term follow-up and review of the Bone Conduction Implant
- 2022
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Ingår i: Hearing Research. - : Elsevier BV. - 0378-5955 .- 1878-5891. ; 421
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Tidskriftsartikel (refereegranskat)abstract
- Active transcutaneous bone conduction devices are a type of bone conduction device developed to keep the skin intact and provide direct bone conduction stimulation. The Bone Conduction Implant (BCI) is such a device and has been implanted in 16 patients. The objective of this paper is to give a broad overview of the BCI development to the final results of 13 patients at 5-year follow-up. Follow-up of these patients included audiological performance investigations, questionnaires, as well as safety evaluation and objective functionality testing of the device. Among those audiological measure-ments were sound field warble tone thresholds, speech recognition threshold (SRT), speech recognition score (SRS) and signal to noise ratio threshold (SNR-threshold).The accumulated implant time for all 16 patients was 113 years in February 2022. During this time, no serious adverse events have occurred. The functional improvement for the 13 patients reported in this paper was on average 29.5 dB (average over 0.5, 1, 2 and 4 kHz), while the corresponding effective gain was-12.4 dB. The SRT improvement was 24.5 dB and the SRS improvement was 38.1%, while the aided SNR-threshold was on average -6.4 dB.It was found that the BCI can give effective and safe hearing rehabilitation for patients with conduc-tive and mild-to-moderate mixed hearing loss. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
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| 573. |
- Reinfeldt, Sabine, 1978, et al.
(författare)
-
Nasal sound pressure as objective verification of implant in active transcutaneous bone conduction devices
- 2019
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Ingår i: Medical Devices: Evidence and Research. - 1179-1470. ; 12, s. 193-202
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Active transcutaneous bone conduction devices consist of an external audio processor and an internal implant under intact skin. During the surgical procedure, it is important to verify the functionality of the implant before the surgical wound is closed. In a clinical study with the new bone conduction implant (BCI), the functionality of the implant was tested with an electric transmission test, where the output was the nasal sound pressure (NSP) recorded in the ipsilateral nostril. The same measurement was performed in all follow-up visits to monitor the implant's functionality and transmission to bone over time. The objective of this study was to investigate the validity of the NSP method as a tool to objectively verify the implant's performance intraoperatively, as well as to follow-up the implant's performance over time. Design: Thirteen patients with the BCI were included, and the NSP measurement was part of the clinical study protocol. The implant was electrically stimulated with an amplitude-modulated signal generator using a swept sine 0.1-10 kHz. The NSP was measured with a probe tube microphone in the ipsilateral nostril. Results: The NSP during surgery was above the noise floor for most patients within the frequency interval 0.4-5 kHz, showing NSP values for expected normal transmission of a functioning implant. Inter-subject comparison showed large variability, but follow-up results showed only minor variability within each subject. Further investigation showed that the NSP was stable over time. Conclusion: The NSP method is considered applicable to verify the implant's functionality during and after surgery. Such a method is important for implantable devices, but should be simplified and clinically adapted. Large variations between subjects were found, as well as smaller variability in intra-subject comparisons. As the NSP was found to not change significantly over time, stable transmission to bone, and implant functionality, were indicated.
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| 574. |
- Reinfeldt, Sabine, 1978, et al.
(författare)
-
The bone conduction implant: Clinical results of the first six patients.
- 2015
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Ingår i: International journal of audiology. - : Informa UK Limited. - 1708-8186 .- 1499-2027. ; 54:6, s. 408-416
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate audiological and quality of life outcomes for a new active transcutaneous device, called the bone conduction implant (BCI), where the transducer is implanted under intact skin. Design: A clinical study with sound field audiometry and questionnaires at six-month follow-up was conducted with a bone-anchored hearing aid on a softband as reference device. Study sample: Six patients (age 18-67 years) with mild-to-moderate conductive or mixed hearing loss. Results: The surgical procedure was found uneventful with no adverse events. The first hypothesis that BCI had a statistically significant improvement over the unaided condition was proven by a pure-tone-average improvement of 31.0 dB, a speech recognition threshold improvement in quiet (27.0 dB), and a speech recognition score improvement in noise (51.2 %). At speech levels, the signal-to-noise ratio threshold for BCI was - 5.5 dB. All BCI results were better than, or similar to the reference device results, and the APHAB and GBI questionnaires scores showed statistically significant improvements versus the unaided situation, supporting the second and third hypotheses. Conclusions: The BCI provides significant hearing rehabilitation for patients with mild-to-moderate conductive or mixed hearing impairments, and can be easily and safely implanted under intact skin.
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| 575. |
- Rezvani, Zeinab, 1981-, et al.
(författare)
-
Advances in consumer electric vehicle adoption research : a review and research agenda
- 2015
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Ingår i: Transportation Research Part D. - Oxford : Elsevier. - 1361-9209 .- 1879-2340. ; 34, s. 122-136
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Tidskriftsartikel (refereegranskat)abstract
- In spite of the purported positive environmental consequences of electrifying the light duty vehicle fleet, the number of electric vehicles (EVs) in use is still insignificant. One reason for the modest adoption figures is that the mass acceptance of EVs to a large extent is reliant on consumers’ perception of EVs. This paper presents a comprehensive overview of the drivers for and barriers against consumer adoption of plug-in EVs, as well as an overview of the theoretical perspectives that have been utilized for understanding consumer intentions and adoption behavior towards EVs. In addition, we identify gaps and limitations in existing research and suggest areas in which future research would be able to contribute.
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| 576. |
- Rezvani, Zeinab, 1981-, et al.
(författare)
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Antecedents to and consequences of consumer’s hedonic goals related to pro-environmental behaviors
- 2015
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Konferensbidrag (refereegranskat)abstract
- Consumer's anticipated emotions have been shown to impact behavioral intentions. Moreover, consumer's anticipated emotions are argued to be influenced by the appraisals of the consumption situation. Understanding these appraisals can clarify some of the reasons underlying different anticipated emotions. Previous research demonstrate associations between positive (i.e., pride, joy) and negative (i.e., guilt, shame) anticipated emotions with consumer's intention for pro-environmental behavior. However, in previous studies, antecedents to consumer's anticipated emotions have been overlooked. This paper contributes in investigating the antecedents and consequences of anticipated emotions in consumer pro-environmental behavior and consequently provides implications for designing communication, education and policy for encouraging consumer's willingness for pro-environmental behavior. Utilizing Izard's (1977) Differential Emotions Scale, this paper examines the relationship between a set of positive and negative anticipated emotions and consumer intentions to adopt a pro-environmental behavior (here adoption of electric vehicles). Moreover, the relation of anticipated emotions with a set of attitudinal factors, adopted from Stern (2000), as the antecedents to the anticipated emotions, is studied. Utilizing a questionnaire (N = 576), and structural equation modeling, we find a significant relationship between consumers' attitude towards electric vehicles and their anticipated emotions. A significant relationship between consumers' attitude towards environmental impacts of driving and anticipated emotions is also found. Positive anticipated emotions are significant predictors of consumers' intentions to adopt electric vehicles.
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| 577. |
- Rezvani, Zeinab, 1981-, et al.
(författare)
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Cause I'll Feel Good! An Investigation into the Effects of Anticipated Emotions and Personal Moral Norms on Consumer Pro-Environmental Behavior
- 2017
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Ingår i: Journal of Promotion Management. - : Routledge. - 1049-6491 .- 1540-7594. ; 23:1, s. 163-183
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Tidskriftsartikel (refereegranskat)abstract
- Anticipated emotions and moral norms have previously been found to influence consumer adoption of pro-environmental products in different ways. However norms and emotions have seldom been combined in order to understand their relations in motivating consumers to adopt sustainable products. Despite the environmental benefits of sustainable products, consumer adoption is slow to take off. Utilizing data from an online survey (N = 576), this study finds that anticipated emotions directly influence consumer adoption and the effect of moral norms is mediated by the anticipated emotions. This study extends the norm activation model and implies communicating positive emotions for promoting sustainable products.
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| 578. |
- Rezvani, Zeinab, 1981-, et al.
(författare)
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Cause I’m Feeling Good! The Influence of Anticipated Emotions on Consumer Pro-environmental Behavior
- 2016
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Ingår i: Rediscovering the Essentiality of Marketing. - Cham : Springer. - 9783319298771 - 9783319806761 - 9783319298764 ; , s. 117-125
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Konferensbidrag (refereegranskat)abstract
- Although consumers express environmental attitudes, the pro-environmental behaviors are not dominant. Despite the benefits of sustainable technologies in reducing the environmental impacts of consumption, consumer adoption of these technologies is very slow to take off. We propose an integrated approach for investigating the effect of consumer anticipated emotions and moral norms on consumer adoption of a sustainable technology (electric vehicles). 576 Swedish car drivers participated in an online survey during winter of 2013. Our findings suggest that anticipated emotions directly influence consumer adoption intentions and the effect of moral norms on behavioral intentions is mediated by the anticipated emotions. The findings have implications for policymakers and car producers in promoting the zero emission transportation. We suggest communicating the positive emotions related to driving an electric vehicle and use of emotions in cars' energy labelling.
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| 579. |
- Rezvani, Zeinab, 1981-, et al.
(författare)
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Consumer Adoption of High-Involvement Sustainable Products : Exploring the Interplay of Gain, Normative, and Hedonic Motivations and the Role of Perceived Social Norm
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Recent conceptual studies identify gain, normative, and hedonic factors as three categories of motivation of consumer pro-environmental behavior. However, empirical understanding of how these motivations interact and affect pro-environmental behavior is limited. This study is based on a survey of car owners in Sweden and utilizes structural equation modeling to analyze the data. The empirical findings show that consumers’ hedonic motivations mediate the effect of normative and gain motivations on pro-environmental behavioral intentions. For consumers who perceive high social norms with regard to sustainable consumption, the direct effect of hedonic motivations on behavioral intention is stronger and the direct effect of gain motivations is insignificant. The business strategy implications point to targeting consumers who perceive high social norms in relation to pro-environmental behavior and communicating the hedonic and normative aspects of pro-environmental behaviors.
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| 580. |
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