| 1021. |
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| 1022. |
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| 1023. |
- Jiménez, C., et al.
(författare)
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Performance simulations for a submillimetre-wave satellite instrument to measure cloud ice
- 2007
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Ingår i: Quarterly Journal of the Royal Meteorological Society. - : Wiley. - 0035-9009 .- 1477-870X. ; 133:S2, s. 129-149
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Tidskriftsartikel (refereegranskat)abstract
- The performance of a conically scanning satellite instrument for the measurement of cloud ice was studied. The instrument measures radiances in 12 channels placed around the 183, 325 and 448 GHz water vapour lines and the 243, 664 and 874 GHz window channels, and is designed to provide estimations of ice water path (IWP), the equivalent sphere diameter (DME), and the median ice mass height (ZME). Overall median relative errors of around 20% for IWP, 33 µm for DME, and 240 m for ZME for a midlatitude winter scenario, and 17% for IWP, 30 µm for DME, and 310 m for ZME for a tropical scenario were found. Detection limits (relative retrieval error reaching 100%) of around 2 gm−2 were estimated for both scenarios. The performance of a five-receiver instrument, where either the 664 or 874 GHz channel is dropped, was close, but with increased errors for very thin and high clouds. A trade-off between having the 874 GHz receiver or two infrared channels at 10.7 and 12 µm emerged, as very similar performance was found between the six-receiver instrument and the five-receiver instrument with the infrared channels. Another trade-off between receiver selection and noise was also apparent, with some of the four-receiver selections operating at half noise levels being able to compete with the standard six-receiver instrument. Dual-polarized measurements were also tested, but they did not significantly improve the retrievals of IWP or DME.
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| 1024. |
- Jimenez-Ferrer, Itzia, et al.
(författare)
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The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease
- 2021
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Ingår i: Brain, Behavior, and Immunity. - : Elsevier BV. - 0889-1591. ; 91, s. 369-382
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Tidskriftsartikel (refereegranskat)abstract
- Background: Abnormal folding, aggregation and spreading of alpha-synuclein (αsyn) is a mechanistic hypothesis for the progressive neuropathology in Parkinson's disease (PD). Spread of αsyn between cells is supported by clinical, neuropathological and experimental evidence. It has been proposed that a pro-inflammatory micro-environment in response to αsyn can promote its aggregation. We have previously shown that allelic differences in the major histocompatibility complex class two transactivator (Mhc2ta) gene, located in the VRA4 locus, alter MHCII expression levels, microglial activation and antigen presentation capacity in rats upon human αsyn over-expression. In addition, Mhc2ta regulated dopaminergic neurodegeneration and the extent of motor impairment. The purpose of this study was to determine whether Mhc2ta regulates αsyn aggregation, propagation and dopaminergic pathology in an αsyn pre-formed fibril (PFF)-seeded in vivo model of PD. Methods: The DA and DA.VRA4 congenic rat strains share background genome but display differential microglial antigen presenting capacity due to different Mhc2ta alleles in the VRA4 locus. PFFs of human αsyn or BSA solution were injected unilaterally to the striatum of DA and DA.VRA4 rats two weeks after ipsilateral administration of recombinant adeno-associated virus (rAAV) vectors carrying human αsyn or GFP to the substantia nigra pars compacta. Behavioural assessment was performed at 2, 5 and 8 weeks while histological evaluation of αsyn pathology, inflammation and neurodegeneration as well as determination of serum cytokine profiles were performed at 8 weeks. Results: rAAV-mediated expression of human αsyn in nigral dopaminergic neurons combined with striatal PFF administration induced enhanced αsyn pathology in DA.VRA4 compared to DA rats. Mhc2ta thus significantly regulated the seeding, propagation and toxicity of αsyn in vivo. This was reflected in terms of wider extent and anatomical distribution of αsyn inclusions, ranging from striatum to the forebrain, midbrain, hindbrain and cerebellum in DA.VRA4. Compared to DA rats, DA.VRA4 also displayed enhanced motor impairment and dopaminergic neurodegeneration as well as higher levels of the proinflammatory cytokines IL-2 and TNFα in serum. Conclusions: We conclude that the key regulator of MHCII expression, Mhc2ta, modulates neuroinflammation, αsyn-seeded Lewy-like pathology, dopaminergic neurodegeneration and motor impairment. This makes Mhc2ta and microglial antigen presentation promising therapeutic targets for reducing the progressive neuropathology and clinical manifestations in PD.
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| 1025. |
- Jimenez-Halla, J. Oscar C., et al.
(författare)
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Computational study of the mechanism and selectivity of palladium catalyzed propargylic substitution with phosphorus nucleophiles
- 2012
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Ingår i: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 18:39, s. 12424-12436
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Tidskriftsartikel (refereegranskat)abstract
- The mechanism and sources of selectivity in the palladium-catalyzed propargylic substitution reaction that involves phosphorus nucleophiles, and which yields predominantly allenylphosphonates and related compounds, have been studied computationally by means of density functional theory. Full free-energy profiles are computed for both H-phosphonate and H-phosphonothioate substrates. The calculations show that the special behavior of H-phosphonates among other heteroatom nucleophiles is indeed reflected in higher energy barriers for the attack on the central carbon atom of the allenyl/propargyl ligand relative to the ligand-exchange pathway, which leads to the experimentally observed products. It is argued that, to explain the preference of allenyl- versus propargyl-phosphonate/phosphonothioate formation in reactions that involve H-phosphonates and H-phosphonothioates, analysis of the complete free-energy surfaces is necessary, because the product ratio is determined by different transition states in the respective branches of the catalytic cycle. In addition, these transition states change in going from a H-phosphonate to a H-phosphonothioate nucleophile.
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| 1026. |
- Jimenez-Halla, J. Oscar C., et al.
(författare)
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Organomagnesium clusters : Structure, stability, and bonding in archetypal models
- 2011
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Ingår i: Journal of Organometallic Chemistry. - : Elsevier BV. - 0022-328X .- 1872-8561. ; 696:25, s. 4104-4111
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Tidskriftsartikel (refereegranskat)abstract
- We have studied the molecular structure and the nature of the chemical bond in the monomers and tetramers of the Grignard reagent CH(3)MgCl as well as MgX(2) (X = H, Cl, and CH(3)) at the BP86/TZ2P level of theory. For the tetramers, we discuss the stability of three possible molecular structures of C(2h), D(2h), and T(d) symmetry. The most stable structure for (MgCl(2))(4) is D(2h), the one for (MgH(2))(4) is C(2h), and that of (CH(3)MgCl)(4) is T(d). The latter is 38 kcal/mol more stable with chlorines in bridge positions and methyl groups coordinated to a Mg vertex than vice versa. We find through a quantitative energy decomposition analysis (EDA) that the tetramerization energy is predominantly composed of electrostatic attraction Delta V(elstat) (60% of all bonding terms Delta V(elstat) + Delta E(oi)) although the orbital interaction Delta E(oi) also provides an important contribution (40%).
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| 1027. |
- Jiménez-Murcia, Susana, et al.
(författare)
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A comparison of DSM-IV-TR and DSM-5 diagnostic criteria for gambling disorder in a large clinical sample
- 2019
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 10:APR
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Gambling-related crimes are known to be associated with gambling disorder (GD). Due to a lack of consensus in the scientific community regarding the relevance of this diagnostic criterion, it was removed from the DSM-5. The primary aim of this study was to investigate through structural equation modeling (SEM) whether higher GD severity in treatment-seeking GD patients with a criminal record is mediated through the illegal acts criterion itself, or whether it can be better explained by other related clinical factors. Methods: An initial sample of 2,081 patients seeking treatment for gambling problems was included in the sample. SEM was used to evaluate the mediational role of the illegal acts criterion between the sex, age and personality traits, gambling severity, and comorbid depression levels. Comparisons between patients with coinciding and divergent DSM criterion for GD diagnosis were carried out. Results: Illegal acts mediated the relationship between personality traits and GD severity: younger age, high levels of novelty seeking, and low levels of self-transcendence increased the risk of endorsing the illegal acts criterion. No differences between coincident-divergent groups in terms of DSM-IV and DSM-5 diagnosis were found with regards to sex (p=.878), education level (p=.387) or civil status (p=.792). Discussion and conclusions: The results obtained in the present study offer new insights into the utility of using a history of illegal acts, their different personality characteristics and psychopathology to categorize GD patients. Our findings suggest that patients who engage in criminal behavior may require a more comprehensive intervention.
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| 1028. |
- Jiménez-Murcia, Susana, et al.
(författare)
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Treatment outcome in male Gambling Disorder patients associated with alcohol use
- 2016
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 7:MAR
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The primary objective of this study was to analyze the association between alcohol consumption and short-term response to treatment (post intervention) in male patients with gambling disorder enrolled in a group cognitive behavioral therapy (CBT) program. Methods: The sample consisted of 111 male individuals with a diagnosis of Gambling Disorder, with a mean age of 45 years (SD = 12.2). All participants were evaluated by a comprehensive assessment battery and assigned to CBT groups of 10-14 patients attending 16 weekly outpatient sessions lasting 90 min each. Results: The highest mean pre- and post-therapy differences were recorded for the alcohol risk/dependence group on the obsessive/compulsive and anxiety dimensions of the SCL-90-R. As regards the presence of relapses and dropouts over the course of the CBT sessions, the results show a significant association with moderate effect size: Patients with risk consumption or alcohol dependence were more likely to present poor treatment outcomes. Conclusions: Alcohol abuse was frequent in GD, especially in patients with low family income and high accumulated debts. High levels of somatization and high overall psychopathology (measured by the SCL-90-R) were associated with increased risk of alcohol abuse. Alcohol abuse was also associated with poor response to treatment.
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| 1029. |
- Jiménez-Navarro, Inmaculada C., et al.
(författare)
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Application of an integrated catchment-lake model approach for simulating effects of climate change on lake inputs and biogeochemistry
- 2023
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 885
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Tidskriftsartikel (refereegranskat)abstract
- Climate change is simultaneously affecting lakes and their catchments, resulting in altered runoff patterns in the catchment and modified mixing and biogeochemical dynamics in lakes. The effects of climate change in a catchment will eventually have an impact on the dynamics of a downstream water body as well. An integrated model would allow considering how changes in the watershed affect the lake, but coupled modelling studies are rare. In this study we integrate a catchment model (SWAT+) and a lake model (GOTM-WET) to obtain holistic predictions for Lake Erken, Sweden. Using five different global climate models, projections of climate, catchment loads and lake water quality for the mid and end of the 21st century have been obtained under two future scenarios (SSP 2-45 and SSP 5-85). Temperature, precipitation and evapotranspiration will increase in the future, overall resulting in an increase in water inflow to the lake. An increasing importance of surface runoff will also have consequences on the catchment soil, hydrologic flow paths, and the input of nutrients to the lake. In the lake, water temperatures will rise, leading to increased stratification and a drop in oxygen levels. Nitrate levels are predicted to remain unchanged, while phosphate and ammonium levels increase. A coupled catchment-lake configuration such as that illustrated here allows prediction of future biogeochemical conditions of a lake, including linking land use changes to changing lake conditions, as well as eutrophication and browning studies. Since climate affects both the lake and the catchment, simulations of climate change should ideally take into account both systems.
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| 1030. |
- Jiménez-Peñuela, Jéssica, et al.
(författare)
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Differences in fatty acids composition between Plasmodium infected and uninfected house sparrows along an urbanization gradient
- 2022
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 815
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Tidskriftsartikel (refereegranskat)abstract
- Anthropogenic activities such as intensification of agriculture, animal husbandry and expansion of cities can negatively impact wildlife through its influence on the availability of high-quality food resources and pathogen transmission. The house sparrow (Passer domesticus), an urban exploiter, is undergoing a population decline. Nutritional constrains and infectious diseases has been highlighted as potential causes. Fatty acids (FAs) play an important role in modulating certain immune responses needed to combat parasite infections. FAs are highly influenced by dietary availability and have been shown to vary between urban and rural birds. Habitat anthropization also affects avian malaria epidemiology but little attention has been given to the relationship between blood parasite infection, host FAs composition and anthropization. Here, we analysed 165 juvenile birds either infected by Plasmodium or uninfected, captured at 15 localities grouped in triplets containing urban, rural and natural habitats. The total level of FAs was higher in birds from urban than from rural habitats, suggesting a greater availability of fat-rich foods sources. Furthermore, Plasmodium infected birds had higher relative levels of ω-3 polyunsaturated fatty acids (PUFAs) but lower of ω-6 PUFAs than uninfected birds. In concordance, the ω-6/ω-3 ratio was also lower in infected than in uninfected birds, but only from natural habitats, likely driven by the slightly higher ω-3 PUFAs in infected birds from natural habitats. Birds from anthropized environments may metabolize the ω-3 PUFAs to promote anti-inflammatory responses against stressors, which would result in lower ω-3 affecting their response against Plasmodium. Alternatively, lower ω-6 PUFAs may influence birds susceptibility to infection due to a weaker pro-inflammatory response. These descriptive results do not allow us to identify the causality of these associations but highlight the need to further investigate the relevance of FAs for birds to fight infectious diseases in habitats with different degree of urbanization.
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