| 2011. |
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| 2012. |
- Petrén, Henrik, et al.
(author)
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eta-meson production in proton-proton collisions at excess energies of 40 and 72 MeV
- 2010
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 82:5, s. 055206-
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Journal article (peer-reviewed)abstract
- The production of eta mesons in proton-proton collisions has been studied using the WASA detector at the CELSIUS storage ring at excess energies of Q = 40 MeV and Q = 72 MeV. The eta was detected through its 2 gamma decay in a near-4 pi electromagnetic calorimeter, whereas the protons were measured by a combination of straw chambers and plastic scintillator planes in the forward hemisphere. About 6.9 x 10(4) and 9.3 x 10(4) events were found at Q = 40 MeV and Q = 72 MeV, respectively, with background contributions of less than 5%. A simple parametrization of the production cross section in terms of low partial waves was used to evaluate the acceptance corrections. Strong evidence was found for the influence of higher partial waves. The Dalitz plots show the presence of p waves in both the pp and the eta {pp} systems and the angular distributions of the eta in the center-of-mass frame suggest the influence of d-wave eta mesons.
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| 2013. |
- Phillipson, Mia, et al.
(author)
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The gastric mucus layers: constituents and regulation of accumulation.
- 2008
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In: American journal of physiology. Gastrointestinal and liver physiology. - : American Physiological Society. - 0193-1857 .- 1522-1547. ; 295:4
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Journal article (peer-reviewed)abstract
- The mucus layer continuously covering the gastric mucosa consists of a loosely adherent layer that can be easily removed by suction, leaving a firmly adherent mucus layer attached to the epithelium. These two layers exhibit different gastroprotective roles; therefore, individual regulation of thickness and mucin composition were studied. Mucus thickness was measured in vivo with micropipettes in anesthetized mice [isoflurane; C57BL/6, Muc1-/-, inducible nitric oxide synthase (iNOS)-/-, and neuronal NOS (nNOS)-/-] and rats (inactin) after surgical exposure of the gastric mucosa. The two mucus layers covering the gastric mucosa were differently regulated. Luminal administration of PGE(2) increased the thickness of both layers, whereas luminal NO stimulated only firmly adherent mucus accumulation. A new gastroprotective role for iNOS was indicated since iNOS-deficient mice had thinner firmly adherent mucus layers and a lower mucus accumulation rate, whereas nNOS did not appear to be involved in mucus secretion. Downregulation of gastric mucus accumulation was observed in Muc1-/- mice. Both the firmly and loosely adherent mucus layers consisted of Muc5ac mucins. In conclusion, this study showed that, even though both the two mucus layers covering the gastric mucosa consist of Muc5ac, they are differently regulated by luminal PGE(2) and NO. A new gastroprotective role for iNOS was indicated since iNOS-/- mice had a thinner firmly adherent mucus layer. In addition, a regulatory role of Muc1 was demonstrated since downregulation of gastric mucus accumulation was observed in Muc1-/- mice.
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| 2014. |
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| 2015. |
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| 2016. |
- Pircs, Karolina, et al.
(author)
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Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease
- 2022
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In: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 145:9, s. 3035-3057
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Journal article (peer-reviewed)abstract
- Huntington's disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in aging humans. To address this, we generated induced neurons (iNs) through direct reprogramming of human skin fibroblasts, which retain age-dependent epigenetic characteristics. HD-iNs displayed profound deficits in autophagy, characterised by reduced transport of late autophagic structures from the neurites to the soma. These neurite-specific alterations in autophagy resulted in shorter, thinner and fewer neurites specifically in HD-iNs. CRISPRi-mediated silencing of HTT did not rescue this phenotype but rather resulted in additional autophagy alterations in ctrl-iNs, highlighting the importance of wild type HTT in normal neuronal autophagy. In summary, our work identifies a distinct subcellular autophagy impairment in adult patient derived Huntington's disease neurons and provides a new rational for future development of autophagy activation therapies.
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| 2017. |
- Plym, Anna, et al.
(author)
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Causes of sick leave, disability pension, and death following a breast cancer diagnosis in women of working age
- 2019
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In: Breast. - : CHURCHILL LIVINGSTONE. - 0960-9776 .- 1532-3080. ; 45, s. 48-55
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Journal article (peer-reviewed)abstract
- Objectives: Women diagnosed with breast cancer during working age are at increased risk of permanent absence from work, but the underlying medical causes have rarely been studied. We examined the risk of cause-specific sick leave, disability pension, and the competing event death after a breast cancer diagnosis in a population-based cohort study.Materials and methods: From the Breast Cancer Data Base Sweden, we identified 16,603 women diagnosed with stage I-III breast cancer between 2000 and 2012, and 63,773 control women. Using multi-state modelling, we calculated probabilities and durations of sick leave, disability pension, and death by registered cause, together with cause-specific hazard ratios.Results: Five years after diagnosis, causes other than cancer accounted for around half of all sick leave (3.5% out of 6.8% of women) and disability pension (1.4% out of 2.6%) in women with breast cancer. Compared with control women, women with breast cancer were at increased risk of sick leave and disability pension due to mental disorders (HR 1.24, 95% CI 1.15-1.33 and HR 1.54, 95% CI 1.29-1.85, respectively) and disability pension due to inflammatory diseases (HR 1.46, 95% CI 1.05-2.03). The risk of sick leave and disability pension due to cardiovascular disease was also elevated, although only statistically significant for disability pension in women diagnosed after 2005 (HR 2.24, 95% CI 1.22-4.13).Conclusion: Follow-up, support, and rehabilitation programs for women diagnosed with breast cancer must address a wide range of psychological and physical conditions to limit the consequences on working life.
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| 2018. |
- Plym, Anna, et al.
(author)
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Impact of chemotherapy, radiotherapy, and endocrine therapy on sick leave in women with early-stage breast cancer during a 5-year period : a population-based cohort study
- 2020
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In: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 182:3, s. 699-707
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Journal article (peer-reviewed)abstract
- Purpose: To examine the influence of type of oncological treatment on sick leave in women of working age with early-stage breast cancer.Methods: We identified 8870 women aged 30-64 diagnosed with stage I-II breast cancer between 2005 and 2012 in the Breast Cancer Data Base Sweden. Associations between type of oncological treatment (radiotherapy, endocrine therapy, and chemotherapy) and sick leave were estimated by hazard ratios, probabilities, and length of sick leave using multi-state survival analysis.Results: During the first 5 years after diagnosis, women aged 50-54 years at diagnosis receiving chemotherapy spent on average 182 (95% CI 151-218) additional days on sick leave compared with women not receiving chemotherapy, but with otherwise similar characteristics. Correspondingly, women initiating endocrine therapy spent 30 (95% CI 18-44) additional days on sick leave and women receiving post-mastectomy radiotherapy 53 (95% CI 37-69) additional days. At year five, the rate of sick leave was increased in women who had received chemotherapy (HR 1.19, 95% CI 1.11-1.28) or endocrine therapy (HR 1.15, 95% CI 1.05-1.26). Chemotherapy and endocrine therapy were associated with increased rates of sick leave due to depression or anxiety.Conclusion: Our findings of increased long-term risks of sick leave after oncological treatment for breast cancer warrant attention from caregivers taking part in cancer rehabilitation. In light of the ongoing debate about overtreatment of early-stage breast cancer, our findings point to the importance of properly selecting patients for chemotherapy not only for the medical toxicity but also the possible impact on their livelihood.
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| 2019. |
- Pomp, Stephan, et al.
(author)
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Neutron-induced light-ion production from Fe, Pb and U at 96 MeV
- 2007
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In: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 126:1-4, s. 123-125
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Journal article (peer-reviewed)abstract
- Double-differential cross-sections for light-ion production (up to A = 4) induced by 96 MeV neutrons have been measured for Fe, Pb and U. The experiments have been performed at The Svedberg Laboratory in Uppsala, using two independent devices, MEDLEY and SCANDAL. The recorded data cover a wide angular range (20 degrees-160 degrees) with low energy thresholds. The data have been normalised to obtain cross-sections using up elastic scattering events. The latter have been recorded with the same setup, and results for this measurement are reported. The work was performed within the HINDAS collaboration with the primary aim of improving the database for three of the most important nuclei for incineration of nuclear waste with accelerator-driven systems. The obtained cross-section data are of particular interest for the understanding of the so-called pre-equilibrium stage in a nuclear reaction and will be compared with model calculations.
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| 2020. |
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