| 31. |
- Mäkinen, Taija, et al.
(författare)
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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
- 2001
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 7:2
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Tidskriftsartikel (refereegranskat)abstract
- The lymphatic vasculature transports extravasated tissue fluid, macromolecules and cells back into the blood circulation. Recent reports have focused on the molecular mechanisms regulating the lymphatic vessels. Vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a soluble form of VEGFR-3 is a potent inhibitor of VEGF-C/VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal. Transgenic mice develop a lymphedema-like phenotype characterized by swelling of feet, edema and dermal fibrosis. They survive the neonatal period in spite of a virtually complete lack of lymphatic vessels in several tissues, and later show regeneration of the lymphatic vasculature, indicating that induction of lymphatic regeneration may also be possible in humans.
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| 32. |
- Nasibulin, Albert G., et al.
(författare)
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A novel cement-based hybrid material
- 2009
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Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotubes (CNTs) and carbon nanofibers (CNFs) are known to possess exceptional tensile strength, elastic modulus and electrical and thermal conductivity. They are promising candidates for the next-generation high-performance structural and multi-functional composite materials. However, one of the largest obstacles to creating strong, electrically or thermally conductive CNT/CNF composites is the difficulty of getting a good dispersion of the carbon nanomaterials in a matrix. Typically, time-consuming steps of purification and fimctionalization of the carbon nanomaterial are required. We propose a new approach to grow CNTs/CNFs directly on the surface of matrix particles. As the matrix we selected cement, the most important construction material. We synthesized in a simple one-step process a novel cement hybrid material (CHM), wherein CNTs and CNFs are attached to the cement particles. The CHM has been proven to increase 2 times the compressive strength and 40 times the electrical conductivity of the hardened paste, i.e. concrete without sand. © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.
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| 33. |
- Nasibulina, Larisa I., et al.
(författare)
-
Direct synthesis of carbon nanofibers on cement particles
- 2010
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Ingår i: Transportation Research Record. - : SAGE Publications. - 0361-1981 .- 2169-4052. ; :2142, s. 96-101
-
Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotubes (CNTs) and nanofibers (CNFs) are promising candidates for the next generation of high-performance structural and multifunctional composite materials. One of the largest obstacles to creating strong, electrically or thermally conductive CNT-CNF composites is the difficulty of getting a good dispersion of the carbon nanomaterials in a matrix. Typically, time-consuming steps are required in purifying and functionalizing the carbon nanomaterial. A new approach under which CNTs-CNFs are grown directly on the surface of matrix and matrix precursor particles is proposed. Cement was selected as the precursor matrix, since it is the most important construction material. A novel cement hybrid material (CHM) was synthesized in which CNTs and CNFs are attached to the cement particles by two different methods: screw feeder and fluidized bed reactors. CHM has been proved to increase the compressive strength by two times and the electrical conductivity of the hardened paste by 40 times.
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| 34. |
- Pischik, E, et al.
(författare)
-
Long-term complications in acute porphyria
- 2024
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Ingår i: Liver international : official journal of the International Association for the Study of the Liver. - 1478-3231. ; 44:9, s. 2197-2207
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Tidskriftsartikel (refereegranskat)
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| 35. |
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| 36. |
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| 37. |
- Sardh, E, et al.
(författare)
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Overall Health, Daily Functioning, and Quality of Life in Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
- 2020
-
Ingår i: DIGESTIVE AND LIVER DISEASE. - : Elsevier BV. - 1590-8658. ; 52, s. E35-E35
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 38. |
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| 39. |
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