| 11. |
- Petersson, Bodil, 1967-, et al.
(författare)
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Experimental Heritage as Practice : Approaching the Past through the Present at the Intersection of Art and Archaeology
- 2020
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Ingår i: Internet Archaeology. - York : University of York. - 1363-5387. ; :55, s. 1-84
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Tidskriftsartikel (refereegranskat)abstract
- This text presents the emerging transdisciplinary practice of Experimental Heritage as performed within an ongoing Irish-Swedish research project involving artists and archaeologists. The project is situated simultaneously in western Ireland and south-eastern Sweden. It explores the chosen Irish and Swedish landscapes of Clare and Öland, their similarities and differences, with the aid of combined and integrated artistic and archaeological practices. The starting points for common explorations are: stone and water, movement and time/the multitemporal, and the tangible and intangible aspects of landscape experience. In a transdisciplinary process we explore new ways of combining art, archaeology and heritage within and between these landscapes.One path towards fulfilling the strivings is to explore art, archaeology and heritage through the senses. A phenomenological landscape perspective and an eco-cultural approach is combined with Performance Studies and movement-based practice. These perspectives and methodologies are paired with artistic and archaeological approaches to research such as those conducted through poetry, music, performance, visual arts, physical surveys, mapping and excavations.Methods of working have developed from walking in the landscape to sketching, through visuals, sound and movement, group dialogue, team building and exploring the materiality of making. Group movement-based workshops are used to support receptivity and inner listening for decision making through somatic principles and the senses. The project encourages transdisciplinary as well as translocal practice to arrive at new approaches and perspectives on how the past matters to us in the present and how it might have an impact on the future.To achieve true both transdisciplinary and translocal ways of working through art and archaeology/heritage, we need to expand beyond conventional art and archaeology/heritage research, communication and presentation within the well-known framework of universities, cultural history museums and art institutions. The constraints of these conventions are substituted by alternative settings in the landscape. This landscape-based practice includes method development across disciplines, times and geographic distances. It also includes collaborations with people from local communities that can contribute to the explorations with their perspectives, experiences and stories.The advantage of Experimental Heritage as practice in the landscape is its ability to challenge our current worldview to better understand other times and cultures as well as our own. This in turn provides us with new tools to create alternative futures resting on care and respect for the need for diversity and breaking with boundaries set up between nature and culture as well as hierarchies of central and peripheral. We intend to find out more about the multitemporal layers in the landscapes surrounding us and how they relate to our inner landscapes of multitemporal perception. The combination and equal roles of artists and archaeologists as well as the contributions of researchers, and members of the local communities in this work is crucial. Equality and diversity encourage transdisciplinary knowledge development.
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| 12. |
- Stevens, Kristen N, et al.
(författare)
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19p13.1 is a triple negative-specific breast cancer susceptibility locus
- 2012
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 72, s. 1795-
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Tidskriftsartikel (refereegranskat)abstract
- The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.
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