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Sökning: WFRF:(Kohler S.)

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61.
  • Banning, LCP, et al. (författare)
  • Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia
  • 2020
  • Ingår i: Journal of geriatric psychiatry and neurology. - : SAGE Publications. - 0891-9887 .- 1552-5708. ; 33:5, s. 256-264
  • Tidskriftsartikel (refereegranskat)abstract
    • To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
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62.
  • Beaudon, Emelie, et al. (författare)
  • Lomonosovfonna and Holtedahlfonna ice cores reveal east west disparities of the Spitsbergen environment since AD 1700
  • 2013
  • Ingår i: Journal of Glaciology. - 0022-1430 .- 1727-5652. ; 59:218, s. 1069-1083
  • Tidskriftsartikel (refereegranskat)abstract
    • An ice core extracted from Holtedahlfonna ice cap, western Spitsbergen, record spanning the period 1700–2005, was analyzed for major ions. The leading empirical orthogonal function (EOF) component is correlated with an index of summer melt (log([Na + ]/[Mg 2+ ]) from 1850 and shows that almost 50% of the variance can be attributed to seasonal melting since the beginning of the industrial revolution. The Holtedahlfonna d 18 O value is less negative than in the more easterly Lomonosovfonna ice core, suggesting that moist air masses originate from a closer source, most likely the Greenland Sea. During the Little Ice Age the lower methanesulfonic acid (MSA) concentration and MSA non-sea-salt sulfate fraction are consistent with the Greenland Sea as the main source for biogenic ions in the ice cores. Both the melt index and the MSA fraction suggest that the early decades of the 18th century may have exhibited the coldest summers of the last 300 years in Svalbard. Ammonium concentrations rise from 1880, which may result from the warming of the Greenland Sea or from zonal differences in atmospheric pollution transport over Svalbard. During winter, neutralized aerosols are trapped within the tropospheric inversion layer, which is usually weaker over open seas than over sea ice, placing Holtedahlfonna within the inversion more frequently than Lomonosovfonna.
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