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Sökning: WFRF:(Kovacs Peter)

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51.
  • Turcot, Valerie, et al. (författare)
  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
  • 2018
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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53.
  • Zamora, Juan Carlos, et al. (författare)
  • Considerations and consequences of allowing DNA sequence data as types of fungal taxa
  • 2018
  • Ingår i: IMA Fungus. - : INT MYCOLOGICAL ASSOC. - 2210-6340 .- 2210-6359. ; 9:1, s. 167-185
  • Tidskriftsartikel (refereegranskat)abstract
    • Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018). We consider various genetic processes affecting the distribution of alleles among taxa and find that alleles may not consistently and uniquely represent the species within which they are contained. Should the proposals be accepted, the meaning of nomenclatural types would change in a fundamental way from physical objects as sources of data to the data themselves. Such changes are conducive to irreproducible science, the potential typification on artefactual data, and massive creation of names with low information content, ultimately causing nomenclatural instability and unnecessary work for future researchers that would stall future explorations of fungal diversity. We conclude that the acceptance of DNA sequences alone as types of names of taxa, under the terms used in the current proposals, is unnecessary and would not solve the problem of naming putative taxa known only from DNA sequences in a scientifically defensible way. As an alternative, we highlight the use of formulas for naming putative taxa (candidate taxa) that do not require any modification of the ICN.
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54.
  • Alejandre, Elizabeth M., et al. (författare)
  • Characterization Factors to Assess Land Use Impacts on Pollinator Abundance in Life Cycle Assessment
  • 2023
  • Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 57:8, s. 3445-3454
  • Tidskriftsartikel (refereegranskat)abstract
    • While wild pollinators play a key role in global food production, their assessment is currently missing from the most commonly used environmental impact assessment method, Life Cycle Assessment (LCA). This is mainly due to constraints in data availability and compatibility with LCA inventories. To target this gap, relative pollinator abundance estimates were obtained with the use of a Delphi assessment, during which 25 experts, covering 16 nationalities and 45 countries of expertise, provided scores for low, typical, and high expected abundance associated with 24 land use categories. Based on these estimates, this study presents a set of globally generic characterization factors (CFs) that allows translating land use into relative impacts to wild pollinator abundance. The associated uncertainty of the CFs is presented along with an illustrative case to demonstrate the applicability in LCA studies. The CFs based on estimates that reached consensus during the Delphi assessment are recommended as readily applicable and allow key differences among land use types to be distinguished. The resulting CFs are proposed as the first step for incorporating pollinator impacts in LCA studies, exemplifying the use of expert elicitation methods as a useful tool to fill data gaps that constrain the characterization of key environmental impacts.
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55.
  • Andersson, Petra, et al. (författare)
  • Innovativa elsystem i byggnader : konsekvenser för brandsäkerhet
  • 2019
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Det sker en snabb teknikutveckling i den elektriska miljön i byggnader, framförallt i våra bostäder. Ett exempel är lokal produktion av el, där solcellsinstallationer blir alltmer populära. Sådan elproduktion medför även förändringar i övriga delar av byggnaders elektriska infrastruktur, såsom DC-nät och i vissa fall energilagring i batterisystem. Utvecklingen sker till stor del som ett svar på behovet av mer hållbara lösningar, ur ett växthuseffektperspektiv, för vår elförsörjning, och förstärks bland annat av statligt stöd och ökad tillgänglighet på marknaden.Ny elektrisk teknologi kan leda till ökad brandrisk och denna förstudie har haft som mål att undersöka denna problematik. Metoden har varit workshops med intressenter och experter inom området, intervjuer, samt litteraturstudier.Av de studerade områdena förefaller solcellsanläggningar skapa störst utmaningar i framtiden om inget görs. Detta beror dels på bristfälligt regelverk men även på att dessa system är distribuerade i byggnaderna med flera delar som kan orsaka brand och att delar är exponerade för utomhusklimat vilket får stora konsekvenser vad gäller uppkomst av fel.Brandsäkerheten i samhället har sett ur ett långt tidsperspektiv väsentligt förbättrats. Detta har huvudsakligen drivits fram med hjälp av ett förbättrat regelverk, som ofta inkluderat förbättrade provnings- och kvalificeringsmetoder. En generell observation i detta projekt är att regelverket inte hinner utvecklas i samma takt som tekniken. Detta är en ofta återkommande utmaning inom brandsäkerhet, men gäller speciellt för de teknikområden som behandlas i denna rapport där utvecklingen går mycket snabbt, och de ingående komponenterna nästan uteslutande har stor inneboende brandpotential. Rapporten konstaterar att för att skapa ett relevant regelverk behövs tillämpad forskning, så kallad prenormativ forskning, inom prioriterade områden för att besvara de frågor som ställs vid formulerandet av nya regler och standarder. Exempel på områden som bör prioriteras är 1) komplettering av det än så länge magra statistiska underlaget för bränder i solcellsinstallationer med olycksutredningar, och studier av redan befintliga olycksutredningar, 2) studier av branddynamiken i solcellsinstallationer, såväl byggnadsapplicerade som integrerade, och såväl tak- som fasadmonterade sådana, 3) studier av ljusbågars uppkomst och hur dessa kan undvikas, alternativt hur det kan undvikas att de ger upphov till bränder, 4) skapa underlag för säker installation av batterilager, samt 5) kvalitetssäkring av så kallade second-life batterier, dvs. begagnade batterier, som används i batterilager.
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58.
  • Benz, W., et al. (författare)
  • The CHEOPS mission
  • 2021
  • Ingår i: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 51:1, s. 109-151
  • Tidskriftsartikel (refereegranskat)abstract
    • The CHaracterising ExOPlanet Satellite (CHEOPS) was selected on October 19, 2012, as the first small mission (S-mission) in the ESA Science Programme and successfully launched on December 18, 2019, as a secondary passenger on a Soyuz-Fregat rocket from Kourou, French Guiana. CHEOPS is a partnership between ESA and Switzerland with important contributions by ten additional ESA Member States. CHEOPS is the first mission dedicated to search for transits of exoplanets using ultrahigh precision photometry on bright stars already known to host planets. As a follow-up mission, CHEOPS is mainly dedicated to improving, whenever possible, existing radii measurements or provide first accurate measurements for a subset of those planets for which the mass has already been estimated from ground-based spectroscopic surveys. The expected photometric precision will also allow CHEOPS to go beyond measuring only transits and to follow phase curves or to search for exo-moons, for example. Finally, by unveiling transiting exoplanets with high potential for in-depth characterisation, CHEOPS will also provide prime targets for future instruments suited to the spectroscopic characterisation of exoplanetary atmospheres. To reach its science objectives, requirements on the photometric precision and stability have been derived for stars with magnitudes ranging from 6 to 12 in the V band. In particular, CHEOPS shall be able to detect Earth-size planets transiting G5 dwarf stars (stellar radius of 0.9R⊙) in the magnitude range 6 ≤ V ≤ 9 by achieving a photometric precision of 20 ppm in 6 hours of integration time. In the case of K-type stars (stellar radius of 0.7R⊙) of magnitude in the range 9 ≤ V ≤ 12, CHEOPS shall be able to detect transiting Neptune-size planets achieving a photometric precision of 85 ppm in 3 hours of integration time. This precision has to be maintained over continuous periods of observation for up to 48 hours. This precision and stability will be achieved by using a single, frame-transfer, back-illuminated CCD detector at the focal plane assembly of a 33.5 cm diameter, on-axis Ritchey-Chrétien telescope. The nearly 275 kg spacecraft is nadir-locked, with a pointing accuracy of about 1 arcsec rms, and will allow for at least 1 Gbit/day downlink. The sun-synchronous dusk-dawn orbit at 700 km altitude enables having the Sun permanently on the backside of the spacecraft thus minimising Earth stray light. A mission duration of 3.5 years in orbit is foreseen to enable the execution of the science programme. During this period, 20% of the observing time is available to the wider community through yearly ESA call for proposals, as well as through discretionary time approved by ESA’s Director of Science. At the time of this writing, CHEOPS commissioning has been completed and CHEOPS has been shown to fulfill all its requirements. The mission has now started the execution of its science programme.
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59.
  • Boddaert, S., et al. (författare)
  • Fire safety of BIPV : International mapping of accredited and R&D facilities in the context of codes and standards 2023
  • 2023
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The objective of Task 15 of the IEA Photovoltaic Power Systems Programme is to create an enabling framework to accelerate the penetration of BIPV products in the global market of renewables, resulting in an equal playing field for BIPV products, BAPV products and regular building envelope components, respecting mandatory issues, aesthetic issues, reliability issues, and financial issues.Subtask E of Task 15 is focused on pre-normative international research on BIPV characterisation methods and activity E.3 is dedicated to fire safety of BIPV modules and installations.
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60.
  • Boehle, Frederik, et al. (författare)
  • Compression of CEP-stable multi-mJ laser pulses down to 4 fs in long hollow fibers
  • 2014
  • Ingår i: Laser Physics Letters. - : IOP Publishing. - 1612-2011 .- 1612-202X. ; 11:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Carrier-envelope phase stable 4 fs near-IR pulses with 3 mJ energy were generated by spectral broadening of circularly polarized 8 mJ pulses in a differentially pumped 2 m long composite stretched flexible hollow fiber. The pulses were characterized using both second-harmonic generation frequency-resolved optical gating (SHG-FROG) and SHG d-scan methods.
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