| 61. |
- Boehle, Frederik, et al.
(författare)
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Compression of CEP-stable multi-mJ laser pulses down to 4 fs in long hollow fibers
- 2014
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Ingår i: Laser Physics Letters. - : IOP Publishing. - 1612-2011 .- 1612-202X. ; 11:9
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Tidskriftsartikel (refereegranskat)abstract
- Carrier-envelope phase stable 4 fs near-IR pulses with 3 mJ energy were generated by spectral broadening of circularly polarized 8 mJ pulses in a differentially pumped 2 m long composite stretched flexible hollow fiber. The pulses were characterized using both second-harmonic generation frequency-resolved optical gating (SHG-FROG) and SHG d-scan methods.
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| 62. |
- Breitfeld, Jana, et al.
(författare)
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Genetic dissection of serum vaspin highlights its causal role in lipid metabolism
- 2023
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Ingår i: Obesity. - 1930-7381. ; 31:11, s. 2862-2874
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity-related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated. Methods: A meta-analysis of genome-wide association studies for serum vaspin from six independent cohorts (N = 7446) was conducted. Potential functional variants of vaspin were included in Mendelian randomization (MR) analyses to assess possible causal pathways between vaspin and homeostasis model assessment and lipid traits. To further validate the MR analyses, data from Genotype-Tissue Expression (GTEx) were analyzed, db/db mice were treated with vaspin, and serum lipids were measured. Results: A total of 468 genetic variants represented by five independent variants (rs7141073, rs1956709, rs4905216, rs61978267, rs73338689) within the vaspin locus were associated with serum vaspin (all p < 5×10−8, explained variance 16.8%). MR analyses revealed causal relationships between serum vaspin and triglycerides, low-density lipoprotein, and total cholesterol. Gene expression correlation analyses suggested that genes, highly correlated with vaspin expression in adipose tissue, are enriched in lipid metabolic processes. Finally, in vivo vaspin treatment reduced serum triglycerides in obese db/db mice. Conclusions: The data show that serum vaspin is strongly determined by genetic variants within vaspin, which further highlight vaspin's causal role in lipid metabolism.
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| 63. |
- Bukovics, Peter, et al.
(författare)
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Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury
- 2014
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Ingår i: Peptides. - : Elsevier. - 0196-9781 .- 1873-5169. ; 60, s. 18-22
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Tidskriftsartikel (refereegranskat)abstract
- PACAP has well-known neuroprotective potential including traumatic brain injury (TBI). Its level is up-regulated following various insults of the CNS in animal models. A few studies have documented alterations of PACAP levels in human serum. The time course of post-ictal PACAP levels, for example, show correlation with migraine severity. Very little is known about the course of PACAP levels following CNS injury in humans and the presence of PACAP has not yet been detected in cerebrospinal fluid (CSF) of subjects with severe TBI (sTBI). The aim of the present study was to determine whether PACAP occurs in the CSF and plasma (Pl) of patients that suffered sTBI and to establish a time course of PACAP levels in the CSF and Pl. Thirty eight subjects with sTBI were enrolled with a Glasgow Coma Scale ≤8 on admission. Samples were taken daily, until the time of death or for maximum 10 days. Our results demonstrated that PACAP was detectable in the CSF, with higher concentrations in patients with TBI. PACAP concentrations markedly increased in both Pl and CSF in the majority of patients 24-48h after the injury stayed high thereafter. In cases of surviving patients, Pl and CSF levels displayed parallel patterns, which may imply the damage of the blood-brain barrier. However, in patients, who died within the first week, Pl levels were markedly higher than CSF levels, possibly indicating the prognostic value of high Pl PACAP levels.
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| 64. |
- Cherkin, Daniel, et al.
(författare)
-
The Ninth International Forum for Primary Care Research on Low Back Pain
- 2009
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Ingår i: SPINE. - 0362-2436. ; 34:3, s. 304-307
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Tidskriftsartikel (refereegranskat)abstract
- Study Design. Review of oral and poster presentations and of workshop summaries from the Ninth International Forum for Primary Care Research on Low Back Pain held in Majorca, Spain, October 4-6, 2007. Objective. Summarize highlights of the conference. Summary of Background Data. The International Forum for Primary Care Research on Low Back Pain has become the primary conference for presenting research on the advances in primary care for back pain. Methods. Distillation of the key themes and findings of the research presented at the Forum. Results. Presentations at the forum included intervention studies, psychosocial aspects of low back pain, and epidemiological, clinical, and pathologic studies. Conclusion. The research presented at the forum has contributed to the advancement of understanding of how to improve primary care for low back pain. The Tenth International Forum will occur on June 14-17, 2009, in Boston.
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| 65. |
- Crary, John F., et al.
(författare)
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Primary age-related tauopathy (PART) : a common pathology associated with human aging
- 2014
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 128:6, s. 755-766
-
Tidskriftsartikel (refereegranskat)abstract
- We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer's disease (AD), in the absence of amyloid (A beta) plaques. For these "NFT+/A beta-aEuroe brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as "tangle-only dementia" and "tangle-predominant senile dementia", are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of A beta accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
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| 66. |
- Dalenbäck, Jan-Olof, et al.
(författare)
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Solvärme i fjärrvärmesystem : Utvärdering av primärkopplade system
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Sverige ärett föregångsland när det gälleratt använda solvärme i när-och fjärr-värmesystem.Under perioden 1982 till 1992 byggde vi en serie av anläggningar som alla var större än man byggt i något annat land. Stora bioenergitillgångar och ett stort behov att hitta ersättning för olja i fjärrvärme-systemen ledde parallellt till en mycket positiv utveckling för biobränsle i fjärr-värmesystem, främst flis, och tillsammans med ändrade villkor för demonstrations-anläggningar, kom intresset för stora solvärmeanläggningar av sig i Sverige.Med Bo01 i Malmö 2001 introducerades lokala solvärmesystem i fjärrvärme och med stöd från EU-direktiv med byggnadsfokus har det nu byggts ett antal mindre solvärmeanläggningar i anslutning till olika byggnader med fjärrvärme. De anläggningar som uppfördes på 80-och 90-talet ingick ofta i ett samordnat program med investeringsbidrag och tredjepartsutvärdering och det finns en mängd utvärderingsrapporter.De anläggningar som uppförts under 2000-talet har inte haft samma förutsättningar.Dessutom är det förhållandevis många som anslutits i fjärr-värmesystem.De har ofta initierats genom politiska beslut till del som ett resultat av nya krav på byggnaders energiprestanda och det finns inga andra utvärderingar än anläggningsägarnas egna. I den här rapporten görs en övergripande dokumentation och utvärdering av 22solvärmesystem som anslutits direkt till fjärrvärmesystemen och tagits i drift under perioden 2000till 2010. Utvärdering fokuserar på systemutformning, installation, driftuppföljning och värmeutbyte som kan ligga till grund för rekommendationer till nya anläggningar.Utvärderingen visar att många av anläggningarna har brister såväl med avseende på systemutformning som pådriftuppföljning och värmeutbyte.Det finns anlägg-ningar som ger mer än 300 kWh/år.m2solfångare, vilket får anses acceptabelt, men som medelvärde ger de 8 senast uppförda anläggningarna endast 240 kWh/år.m2 solfångare (2011-2012), varför det finns stort utrymme för förbättringar.Som en övergripande rekommendation föreslås att det bör genomföras ett upp-följningsprojekt under 2013 där de utvärderade anläggningarna följas upp under minst ett år så att alla fås att fungera på ett relevant sätt utgående från dess förutsättningar. Sedan bör erfarenheterna från de utvärderade anläggningarna sammanställas i en enkel projekteringsmall som kan användas i framtida anläggningar.
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| 67. |
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| 68. |
- Damkjær, Jakob T, 1976-, et al.
(författare)
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The photosystem II light-harvesting protein Lhcb3 affects the macrostructure of photosystem II and the rate of state transitions in Arabidopsis
- 2009
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Ingår i: The Plant Cell. - : Oxford University Press (OUP). - 1040-4651 .- 1532-298X. ; 21, s. 3245-3256
-
Tidskriftsartikel (refereegranskat)abstract
- The main trimeric light-harvesting complex of higher plants (LHCII) consists of three different Lhcb proteins (Lhcb1-3). We show that Arabidopsis thaliana T-DNA knockout plants lacking Lhcb3 (koLhcb3) compensate for the lack of Lhcb3 by producing increased amounts of Lhcb1 and Lhcb2. As in wild-type plants, LHCII-photosystem II (PSII) supercomplexes were present in Lhcb3 knockout plants (koLhcb3), and preservation of the LHCII trimers (M trimers) indicates that the Lhcb3 in M trimers has been replaced by Lhcb1 and/or Lhcb2. However, the rotational position of the M LHCII trimer was altered, suggesting that the Lhcb3 subunit affects the macrostructural arrangement of the LHCII antenna. The absence of Lhcb3 did not result in any significant alteration in PSII efficiency or qE type of nonphotochemical quenching, but the rate of transition from State 1 to State 2 was increased in koLhcb3, although the final extent of state transition was unchanged. The level of phosphorylation of LHCII was increased in the koLhcb3 plants compared with wild-type plants in both State 1 and State 2. The relative increase in phosphorylation upon transition from State 1 to State 2 was also significantly higher in koLhcb3. It is suggested that the main function of Lhcb3 is to modulate the rate of state transitions.
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| 69. |
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| 70. |
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