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Sökning: WFRF:(Larsson KJ)

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21.
  • Lindenberg, AM, et al. (författare)
  • Atomic-scale visualization of inertial dynamics
  • 2005
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 308:5720, s. 392-395
  • Tidskriftsartikel (refereegranskat)abstract
    • The motion of atoms on interatomic potential energy surfaces is fundamental to the dynamics of liquids and solids. An accelerator-based source of femtosecond x-ray pulses allowed us to follow directly atomic displacements on an optically modified energy landscape, leading eventually to the transition from crystalline solid to disordered liquid. We show that, to first order in time, the dynamics are inertial, and we place constraints on the shape and curvature of the transition-state potential energy surface. Our measurements point toward analogies between this nonequilibrium phase transition and the short-time dynamics intrinsic to equilibrium liquids.
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  • Reynolds, SJ, et al. (författare)
  • Comparison of endotoxin assays using agricultural dusts
  • 2002
  • Ingår i: AIHA journal : a journal for the science of occupational and environmental health and safety. - : Informa UK Limited. - 1542-8117. ; 63:4, s. 430-438
  • Tidskriftsartikel (refereegranskat)
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  • Smith, LK, et al. (författare)
  • Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma
  • 2022
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1100-
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often characterized by non-genetic adaptive resistance, that in melanoma is characterised by altered metabolism. Here, we examine how targeted therapy reprograms metabolism in BRAF-mutant melanoma cells using a genome-wide RNA interference (RNAi) screen and global gene expression profiling. Using this systematic approach we demonstrate post-transcriptional regulation of metabolism following BRAF inhibition, involving selective mRNA transport and translation. As proof of concept we demonstrate the RNA processing kinase U2AF homology motif kinase 1 (UHMK1) associates with mRNAs encoding metabolism proteins and selectively controls their transport and translation during adaptation to BRAF-targeted therapy. UHMK1 inactivation induces cell death by disrupting therapy induced metabolic reprogramming, and importantly, delays resistance to BRAF and MEK combination therapy in multiple in vivo models. We propose selective mRNA processing and translation by UHMK1 constitutes a mechanism of non-genetic resistance to targeted therapy in melanoma by controlling metabolic plasticity induced by therapy.
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  • Resultat 21-30 av 36

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