| 11. |
- Larsson, Andreas, et al.
(författare)
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Rethinking virtual teams for streamlined development
- 2007
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Ingår i: Higher creativity for virtual teams. - Hershey, PA : Information Science Reference. - 9781599041292 - 1599041294 - 9781599041315 - 1599041316 ; , s. 138-156
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Drawing from experiences in automotive and aerospace development, the authors argue that it is time to radically progress our current understanding of how creativity could be introduced in organizations where factors like legal demands and contractual agreements severely restrict ‘outside-the-box' thinking, and where well-known creativity enablers such as trust, shared goals, and shared culture are becoming increasingly difficult to accomplish.
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| 12. |
- Larsson, Gunilla, 1960-
(författare)
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Ship and Society : Maritime Ideology in Late Iron Age Sweden
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyses the relation between ship and society against a background of ideological and technological changes in Late Iron Age Sweden. It discusses the factors behind the development of ‘a maritime society’, why ships and seafaring came to play an important role that was also reflected in the use of the ship as a symbol and a metaphor in a military context, as well as in religion, administration, jurisdiction and social life. The author argues that this society is disappearing when it is first encountered in the Early Middle Ages, because of a fundamental ideological change.There is a myth about the appearance of the ‘Viking ship’ and the Iron Age seafarer. The ships are supposed to be big and wide. An analysis of the archaeological material presented here shows that this picture is not correct. Instead the ships of the Svear were quite small and built in a way that made them very light. This was a result of shipbuilding methods introduced in the Late Iron Age, and it had consequences for the trade communication network as well as for naval operations. Because of the light ships, it was possible to land on any shallow shore and navigate the shallow rivers in the East.The ship became a key symbol used by the authorities to structure the society for administrative and military purposes, using a terminology based on the Late Iron Age warship.In the Middle Ages, ideology, shipbuilding and seafaring changed. New key symbols were introduced, and they were used by an increasing royal power to consolidate what would become a united Sweden, inspired by feudal Europe.
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| 13. |
- Larsson, Tobias, et al.
(författare)
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Project: ProViking THINK - Team för Heterogen Innovationskunskap
- 2008
-
Annan publikation (populärvet., debatt m.m.)abstract
- Begreppet product-service systems (PSS), eller funktionella produkter, förutspås ha betydande påverkan för ett framtida hållbart samhälle. Ett PSS-synsätt kommer att förändra hur produkter och tjänster används, men också förändra tillvägagångssättet i utvecklingen, eftersom ansvaret för den fysiska produkten genom hela dess livscykel kvarstår hos företaget eller konsortiet som utvecklar PSS-lösningen. I och med detta kan aktiviteterna med omkonstruktion, återanvändning och återvinning, utföras på ett totalt annorlunda sätt än i dag. I den här situationen blir kapaciteten att ständigt förbättra kundupplevt värde genom nya lösningar en viktig förmåga. Således står utvecklingsteam idag inför två stora utmaningar; dels ska de kunna hantera mer abstrakta kundbehov, dels ska de på ett effektivt sätt ständigt bidra till nya lösningar. Det här projektets mål är att stödja PSS-utvecklingsteamets innovationsprocess genom att föreslå faciliterande metoder och verktyg. Specifikt fokus ligger på följande aspekter för att bidra till utvecklingen av en sammanhängande metodologi för team-baserad innovation:- Identifiering, analys och kommunikation av kundbehov samt modellering av värde- Tvärfunktionella team- Effektiv kunskapsdelning- Modellering och visualisering av lösningar baserat på ett kunskapslivscykel perspektiv Projektet kommer att vara en gemensam prestation av industri- och akademirepresentanter. Det praktiska arbetet kommer att utföras i ett nära samarbete. I stort vägleds projektet av antagandet att – visualisering av affärs- och utvecklingsrelaterad kunskap samt snabba modellerings- och simuleringsmöjligheter i tidiga faser stödjer PSS-teamets förmåga att finna nya lösningar och genomföra hållbar utveckling. Förutom ökad kunskap om strategier och tillvägagångssätt för team-baserad innovation kommer demonstratorer av verktyg och metoder vara ett resultat av projektarbetet.
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| 14. |
- Larsson, Tobias, et al.
(författare)
-
Project: VIVACE - Value Improvement Through a Virtual Aeronautical Collaborative Enterprise
- 2006
-
Annan publikation (populärvet., debatt m.m.)abstract
- VIVACE is an Aeronautical Collaborative Design Environment with associated Processes, Models and Methods. This environment will help to design an aircraft and its engines as a whole, providing to the aeronautics supply chain in an extended enterprise, virtual products with all requested functionality and components in each phase of the product engineering life cycle
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| 15. |
- Larsson, Tobias, et al.
(författare)
-
Value Simulation in Conceptual Phases of PSS Design
- 2012
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Konferensbidrag (refereegranskat)abstract
- This paper discuss the change in early design imposed by a Product-Service Systems (PSS) perspective onto the design and development phases of engineering design and how this affects the today de-facto standard of virtual modelling of product properties. The approach is exemplified via PSS situations related to aerospace and automotive industry in order to clarify “parameters of change” due to PSS reasoning, and challenges are displayed regarding early modelling and simulation.
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| 16. |
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| 17. |
- Wallin, Johanna, 1981, et al.
(författare)
-
Measuring Innovation Capability – Assessing Collaborative Performance
- 2011
-
Ingår i: Proceedings of the 3rd CIRP International Conference on Industrial Product Service Systems, Braunschweig, Germany.
-
Konferensbidrag (refereegranskat)abstract
- This paper reports on a qualitative study, carried out at a Swedish aero engine manufacturer. The study was initiated to explore key indicators related to innovation capability in a Product-Service System (PSS) context. Developing PSS changes the dynamics of collaboration, since the offering of such systems usually involves a network of partners sharing the responsibility for a delivered function over a full lifecycle. In particular, this paper focuses on describing aspects related to external and internal collaboration, and it further discusses how to measure the company’s collaborativeperformance, taking into account both activity and effect measures.
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| 18. |
- Wallin, Johanna, et al.
(författare)
-
Measuring Innovation Capability – Assessing Collaborative Performance in Product-Service System Innovation
- 2011
-
Ingår i: - Braunschweig, Germany : Springer. ; , s. 207-2012
-
Konferensbidrag (refereegranskat)abstract
- This paper reports on a qualitative study, carried out at a Swedish aero engine manufacturer. The study was initiated to explore key indicators related to innovation capability in a Product-Service System (PSS) context. Developing PSS changes the dynamics of collaboration, since the offering of such systems usually involves a network of partners sharing the responsibility for a delivered function over a full lifecycle. In particular, this paper focuses on describing aspects related to external and internal collaboration, and it further discusses how to measure the company’s collaborative performance, taking into account both activity and effect measures.
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| 19. |
- Wallin, Johanna, et al.
(författare)
-
Measuring innovation capability in technology-focused development
- 2010
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Ingår i: 17th International Product Development Management Conference. - : University of Murcia.
-
Konferensbidrag (refereegranskat)abstract
- Product development in the aerospace industry is associated with relatively long lead times and product lifecycles, which means that it takes years and even decades to find out if a novel product or technology concept fully realizes its potential and becomes an innovation on the market. How can a company in such an industry context know, preferably already in the conceptual stages, that they are on the path to innovation? How do they know how innovative they are? How can they increase their innovation capability? A project together with Volvo Aero, an aero engine manufacturer, was initiated to explore potential answers to these questions. The paper reports on an ongoing study of the company’s current state-of-practice with regard to measuring innovation capability, starting from a range of innovation indicators provided within a previous research project, which Volvo Aero contributed to. Based on interviews with project managers of advanced engineering projects within the company, six areas were found to be of importance in order to more effectively measure the innovation capability at Volvo Aero: Project selection, Customer involvement, Interaction between functions, Team climate, Innovation methodology and Innovation rewards.Within these areas a selection of preliminary metrics was established, which will be presented in this article along with a discussion on the advantages and drawbacks of combining activity and effect measures to better relate particular activities to particular outcomes.
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| 20. |
- Aaltonen, Kristina E., et al.
(författare)
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Molecular characterization of circulating tumor cells from patients with metastatic breast cancer reflects evolutionary changes in gene expression under the pressure of systemic therapy
- 2017
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:28, s. 45544-45565
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Tidskriftsartikel (refereegranskat)abstract
- Resistance to systemic therapy is a major problem in metastatic breast cancer (MBC) that can be explained by initial tumor heterogeneity as well as by evolutionary changes during therapy and tumor progression. Circulating tumor cells (CTCs) detected in a liquid biopsy can be sampled and characterized repeatedly during therapy in order to monitor treatment response and disease progression. Our aim was to investigate how CTC derived gene expression of treatment predictive markers (ESR1/HER2) and other cancer associated markers changed in patient blood samples during six months of first-line systemic treatment for MBC. CTCs from 36 patients were enriched using CellSearch (Janssen Diagnostics) and AdnaTest (QIAGEN) before gene expression analysis was performed with a customized gene panel (TATAA Biocenter). Our results show that antibodies against HER2 and EGFR were valuable to isolate CTCs unidentified by CellSearch and possibly lacking EpCAM expression. Evaluation of patients with clinically different breast cancer subgroups demonstrated that gene expression of treatment predictive markers changed over time. This change was especially prominent for HER2 expression. In conclusion, we found that changed gene expression during first-line systemic therapy for MBC could be a possible explanation for treatment resistance. Characterization of CTCs at several time-points during therapy could be informative for treatment selection.
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