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  • Result 51-60 of 284
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  • Mishra, A, et al. (author)
  • Diminishing benefits of urban living for children and adolescents' growth and development
  • 2023
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 615:7954, s. 874-883
  • Journal article (peer-reviewed)abstract
    • Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
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  • Park, J, et al. (author)
  • Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
  • 2021
  • In: Cancers. - : MDPI AG. - 2072-6694. ; 13:10
  • Journal article (peer-reviewed)abstract
    • In this study we aim to examine gene–environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
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  • Result 51-60 of 284
Type of publication
journal article (261)
conference paper (12)
research review (2)
Type of content
peer-reviewed (251)
other academic/artistic (24)
Author/Editor
Brenner, H (38)
Zheng, W. (33)
Lee, J. (33)
Liu, Y. (32)
Kwon, Y. (31)
Lee, S (31)
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Yang, Y. (30)
Johnson, SC (30)
Jonas, JB (30)
Martinez, G. (30)
Jia, J. (29)
Milov, A. (29)
Tojo, J. (29)
Lebedev, A. (29)
Kim, HJ (29)
Mao, Y. (29)
Alexander, J (29)
Sato, S. (29)
Gustafsson, Hans-Åke (28)
Oskarsson, Anders (28)
Otterlund, Ingvar (28)
Stenlund, Evert (28)
Tydesjö, Henrik (28)
Bathe, S. (28)
Park, J (28)
Aphecetche, L. (28)
Averbeck, R. (28)
Buesching, H. (28)
Chujo, T. (28)
Delagrange, H. (28)
Glenn, A. (28)
Hamagaki, H. (28)
Klein-Boesing, C. (28)
Miake, Y. (28)
Newby, J. (28)
Oyama, K. (28)
Reygers, K. (28)
Santo, R. (28)
Schutz, Y. (28)
Shigaki, K. (28)
Sugitate, T. (28)
Torii, H. (28)
Zhou, S. (28)
Esumi, S. (28)
Bucher, D. (28)
Soldatov, A. (28)
Matsumoto, T. (28)
Belikov, S (28)
Tanaka, Y. (28)
Hoover, A. (28)
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University
Karolinska Institutet (240)
Lund University (71)
Uppsala University (46)
Umeå University (21)
University of Gothenburg (18)
Högskolan Dalarna (13)
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Linköping University (6)
University of Skövde (5)
Chalmers University of Technology (5)
Royal Institute of Technology (4)
Stockholm University (3)
Örebro University (1)
Jönköping University (1)
Malmö University (1)
Linnaeus University (1)
Karlstad University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (284)
Research subject (UKÄ/SCB)
Medical and Health Sciences (86)
Natural sciences (40)
Engineering and Technology (1)
Social Sciences (1)

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