SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Li BB) "

Search: WFRF:(Li BB)

  • Result 61-70 of 90
Sort/group result
   
EnumerationReferenceCoverFind
61.
  •  
62.
  •  
63.
  • Du, SH, et al. (author)
  • Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
  • 2021
  • In: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 11, s. 603278-
  • Journal article (peer-reviewed)abstract
    • The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases. However, the role of the immunoproteasome in the pathogenesis of immune thrombocytopenia (ITP) remains unknown. We found that the expression of the immunoproteasome catalytic subunit, large multifunctional protease 2 (LMP2), was significantly upregulated in peripheral blood mononuclear cells of active ITP patients compared to those of healthy controls. No significant differences in LMP7 expression were observed between patients and controls. ML604440, an specific LMP2 inhibitor, had no significant impact on the platelet count of ITP mice, while ONX-0914 (an inhibitor of both LMP2 and LMP7) increased the number of platelets. In vitro assays revealed that ONX-0914 decreased the expression of FcγRI in ITP mice and decreased that of FcγRIII in ITP patients, inhibited the activation of CD4+ T cells, and affected the differentiation of Th1 cells in patients with ITP. These results suggest that the inhibition of immunoproteasome is a potential therapeutic approach for ITP patients.
  •  
64.
  •  
65.
  •  
66.
  •  
67.
  •  
68.
  • Haagsma, JA, et al. (author)
  • Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017
  • 2020
  • In: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785 .- 1353-8047. ; 26:SUPP_1Supp 1, s. 12-26
  • Journal article (peer-reviewed)abstract
    • The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates.MethodsInjury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm—the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate.ResultsFor many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced.ConclusionsThe overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum.
  •  
69.
  •  
70.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 61-70 of 90
Type of publication
journal article (82)
conference paper (1)
research review (1)
Type of content
peer-reviewed (81)
other academic/artistic (3)
Author/Editor
Mokdad, AH (37)
Fischer, F (35)
Jonas, JB (35)
Monasta, L (35)
Nangia, V (34)
Negoi, I (33)
show more...
Shaikh, MA (33)
Hay, SI (32)
Mohammed, S (32)
Singh, JA (32)
Majeed, A (30)
Mendoza, W (30)
Miller, TR (30)
Mirrakhimov, EM (30)
Ronfani, L (30)
Khader, YS (29)
Olagunju, AT (29)
Rawaf, S (29)
Samy, AM (29)
Schwebel, DC (29)
Shiri, R (29)
Gupta, R. (28)
Fereshtehnejad, SM (28)
Kisa, A (28)
Radfar, A (28)
Sepanlou, SG (28)
Shigematsu, M (28)
Andrei, CL (27)
Bensenor, IM (27)
Butt, ZA (27)
Castaneda-Orjuela, C ... (27)
Dandona, R (27)
Hamadeh, RR (27)
Islam, SMS (27)
Defo, BK (27)
Malta, DC (27)
Mansournia, MA (27)
Meretoja, TJ (27)
Oh, IH (27)
Aljunid, SM (26)
Arabloo, J (26)
Cardenas, R (26)
Dandona, L (26)
Hosseinzadeh, M (26)
Jha, RP (26)
Khan, EA (26)
Krishan, K (26)
Morrison, SD (26)
Roever, L (26)
Sathian, B (26)
show less...
University
Karolinska Institutet (85)
Uppsala University (21)
Högskolan Dalarna (18)
Lund University (17)
University of Gothenburg (10)
Chalmers University of Technology (6)
show more...
Umeå University (5)
Royal Institute of Technology (3)
Stockholm University (3)
Linköping University (2)
Jönköping University (2)
Mid Sweden University (1)
Södertörn University (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (90)
Research subject (UKÄ/SCB)
Medical and Health Sciences (41)
Natural sciences (5)
Social Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view