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Numrering	Referens	Omslagsbild	Hitta
41.	Clark, DW, et al. (författare) Associations of autozygosity with a broad range of human phenotypes 2019 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957- Tidskriftsartikel (refereegranskat)abstract In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
42.	Delahunt, B, et al. (författare) Active surveillance for prostate cancer: the role of the pathologist 2015 Ingår i: Pathology. - 1465-3931. ; 47:1, s. 1-3 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
43.	Eden, M, et al. (författare) Impact of variation in cancer registration practice on observed international cancer survival differences between International Cancer Benchmarking Partnership (ICBP) jurisdictions 2019 Ingår i: Cancer epidemiology. - : Elsevier BV. - 1877-783X .- 1877-7821. ; 58, s. 184-192 Tidskriftsartikel (refereegranskat)
44.	Kaput, J, et al. (författare) The case for strategic international alliances to harness nutritional genomics for public and personal health 2005 Ingår i: The British journal of nutrition. - : Cambridge University Press (CUP). - 0007-1145 .- 1475-2662. ; 94:5, s. 623-632 Tidskriftsartikel (refereegranskat)abstract Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.
45.	Kendrick, PJ, et al. (författare) Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019 2021 Ingår i: The Lancet. Public health. - : Elsevier. - 2468-2667. ; 6:7, s. E482-E499 Tidskriftsartikel (refereegranskat)
46.	Lambert, JC, et al. (författare) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease 2013 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:12, s. 1452-U206 Tidskriftsartikel (refereegranskat)
47.	Li, M, et al. (författare) Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility 2014 Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 19:4, s. 452-461 Tidskriftsartikel (refereegranskat)
48.	Lin, IH, et al. (författare) Time-Dependent Changes in the Biofluid Levels of Neural Injury Markers in Severe Traumatic Brain Injury Patients-Cerebrospinal Fluid and Cerebral Microdialysates: A Longitudinal Prospective Pilot Study 2023 Ingår i: Neurotrauma reports. - : Mary Ann Liebert Inc. - 2689-288X. ; 4:1, s. 107-117 Tidskriftsartikel (refereegranskat)
49.	Montironi, R, et al. (författare) Consensus statement with recommendations on active surveillance inclusion criteria and definition of progression in men with localized prostate cancer: the critical role of the pathologist 2014 Ingår i: Virchows Archiv : an international journal of pathology. - : Springer Science and Business Media LLC. - 1432-2307. ; 465:6, s. 623-628 Tidskriftsartikel (refereegranskat)
50.	Pathak, GA, et al. (författare) A first update on mapping the human genetic architecture of COVID-19 2022 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 608:7921, s. E1-E10 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)

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Författare/redaktör: Ikram, MA (18); Kim, J. (16); Brenner, H (16); Gudnason, V (16); Jonas, JB (15); Metspalu, A (15); visa fler...; Gill, M. (14); Evans, A. (13); Nothen, MM (13); He, J (13); Zheng, W. (12); Lee, J. (12); Cheng, CY (12); Wong, TY (12); Khaw, KT (12); Wang, YX (12); Liu, J. (11); Gupta, A. (11); Peters, A (11); Gupta, R. (11); Riboli, E. (11); Ma, J (11); Amouyel, P (11); Lehtimaki, T. (11); Taylor, A (11); Salomaa, V (11); O'Donovan, MC (11); Owen, MJ (11); Chen, S. (10); Yang, Y. (10); Li, J. (10); Kumar, S (10); Ruiz, A. (10); Farzadfar, F (10); Malekzadeh, R (10); Sepanlou, SG (10); Singh, A (10); Santos, R. (10); Wang, Q. (10); Johnson, R (10); Ribeiro, R (10); Launer, LJ (10); Easton, DF (10); Elliott, P (10); Vollenweider, P. (10); Jones, L (10); Bauer, M (10); Chen, FF (10); Boehnke, M (10); Hakonarson, H (10); visa färre...

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Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (32); Naturvetenskap (9)

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