| 31. |
- Lindahl, Bengt, et al.
(författare)
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Prospective malignancy grading of invasive squamous carcinoma of the uterine cervix. Prognostic significance in a long-term follow-up.
- 2007
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Ingår i: Anticancer research. - 1791-7530 .- 0250-7005. ; 27:4C, s. 2829-2832
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Tidskriftsartikel (refereegranskat)abstract
- A multifactorial grading score (MGS) for invasive squamous cell carcinoma of the uterine cervix has demonstrated its capacity to predict survival in a 5-10 year perspective and metastasis frequencies, and is a valuable tool for treatment schedules. In this study it was shown that the power of prognosis is valid even up to 20 years. In this material from 619 cervical carcinoma patients the MGS scores turned out to remain as strong as earlier proven. Earlier studies have shown that MGS is superior to other mono- and multifactorial grading systems, histological differentiation into cell types, age, clinical stage, irradiation and DNA-analysis. Treatment of cervical squamous cell carcinoma is more specific today to meet the patients' need for instance to preserve fertility or to minimize operation and eventually radiotherapy. The MGS score is a strong prognostic tool in patients with cervical carcinoma.
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| 32. |
- Lindahl, Bengt, et al.
(författare)
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Relapse of Endometrial Carcinoma : Follow-up of 272 Patients with Relapse
- 2012
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 32:8, s. 3391-3395
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Tidskriftsartikel (refereegranskat)abstract
- A total of 2090 patients with endometrial carcinoma were followed-up for at least five years. The treatment modalities, as well as the results of treatment, regarding 272 patients with disease relapse are presented. The results are not encouraging. We found no statistically significant difference regarding overall survival, when the patients were divided according to initial stage or ploidy status. There was also no significant difference between overall survival and the mode of treatment. 108 out of 272 patients with relapse died of their disease. Regarding patients in stage I-II we present the survival for every studied year, where we compared those with more than one site of metastasis (n=108), more than one metastasis (n=59), or no relapse at all (n=1289) with an age-corrected Swedish female population. We found that the vast majority of patients did not die from their cancer-related illnesses, and also found an increased death-rate among those with cancer without relapse, compared to those without cancer (20% compared to 14%, 5 year follow-up). We conclude that the majority of patients would benefit from an increased effort to cure other illnesses rather than concentrating on cancer treatment alone.
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| 33. |
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| 34. |
- Lindahl, Camilla, 1969-
(författare)
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Tecken av betydelse : En studie av dialog i ett multimodalt, teckenspråkigt tvåspråkigt NO-klassrum.
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Ett gemensamt meningsskapande i skolans naturvetenskapliga klassrum förutsätter en interaktion som i allt högre grad kommer att präglas av ett naturvetenskapligt språkbruk. Utvecklingen av ett naturvetenskapligt ämnesspråk innebär ofta en stor utmaning för flerspråkiga elever som lär sig naturvetenskap på sitt andraspråk och vars behov av stöttning därför är särskilt stort. Denna studie utforskar döva och hörselskadade elevers lärande naturvetenskap i ett tvåspråkigt NO-klassrum där meningsskapandet sker genom svenskt teckenspråk och skriven svenska. Avhandlingens övergripande frågor är hur svenskt teckenspråk och svenska används i dialogen och hur dessa språk, i interaktion med andra modaliteter, bidrar till meningsskapandet i naturvetenskap. En grupp på två lärare och åtta elever, alla döva och teckenspråkig tvåspråkiga, filmades i totalt sjutton NO-lektioner. Klassrumskommunikation i denna teckenspråkigt tvåspråkiga miljö med naturvetenskapliga artefakter som modeller, tabeller och övrig naturvetenskaplig utrustning analyseras sedan från ett multimodalt socialsemiotiskt perspektiv där språk och modaliteter diskuteras som potentiella resurser i meningsskapandet. Resultaten visar en komplex dialog där språk och modaliteter hela tiden växlar på ett sätt som starkt bidrar till att driva dialogen framåt. Vidare framstår det visuella-gestuella teckenspråket som en kraftfull modalitet. I synnerhet spelar avbildande tecken en framträdande roll i dialogen och i det naturvetenskapliga meningsskapandet. Språkväxlingar i den teckenspråkiga dialogen sker dynamiskt i form av sömlösa och spontana växlingar men utnyttjas även som pedagogiskt verktyg. Teckenspråkets kontextbundenhet kräver dessutom ibland tvärspråkliga resonemang på metanivå där oklarheter såväl som likheter och skillnader mellan olika språkliga uttryck kan redas ut. Resultaten uppmärksammar också lärarnas viktiga roll för att stötta eleverna i det naturvetenskapliga meningsskapandet liksom för utvecklingen av ett naturvetenskapligt språk. I diskussionen lyfts behovet av pedagogiska strategier som stärker stöttningen av döva och hörselskadade elevers teckenspråkiga tvåspråkiga meningsskapande i naturvetenskap.
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| 35. |
- Lindahl, Göran, et al.
(författare)
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Stavanger : Innerstaden - Utvecklingshistoria och Utvecklingsmöjligheter
- 1972
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Rapport (populärvet., debatt m.m.)abstract
- Föreliggande arbete bör inte uppfattas som något slags generalplan eller dispositionsplan utan snarare som en presentation av ett synsätt, som konkretiserats på ett antal fritt valda områden. Framställningen har två tyngdpunkter. Stort intresse har ägnats det historiska perspektivet. Syftet har varit att besvara frågan: Varför ser Stavanger ut som det gör? Varför skiljer sig denna stad så mycket från jämförbara orter i Sverige? De svar som ges för över till bokens huvudtema, frågan hur den befintliga bebyggelsen skall användas i framtiden. Bakom ligger en grundsyn som uppfattar rivning och nybyggande som åtgärder i sista hand, underhåll, upprustning och ombyggnad som det normala, något som kan sträckas ut generation eftel" generation.
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| 36. |
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| 37. |
- Lindahl, Mats, 1957-, et al.
(författare)
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Nasal lavage fluid and proteomics as means to identify the effects of the irritating epoxy chemical dimethylbenzylamine
- 2004
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Ingår i: Biomarkers. - : Informa UK Limited. - 1354-750X .- 1366-5804. ; 9:1, s. 56-70
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Tidskriftsartikel (refereegranskat)abstract
- The aims of this study were to describe the changes in the nasal lavage fluid (NLF) protein pattern after exposure to the irritating epoxy chemical dimethylbenzylamine (DMBA) and to identify the affected proteins using a proteomic approach. The protein patterns of NLF from six healthy subjects and eight epoxy workers with airway irritation were analysed using two-dimensional gel electrophoresis (2-DE) before and after exposure to 100 μg m-3 DMBA for 2 h in an exposure chamber. NLF proteins were identified by (i) comparison with a 2-DE NLF reference database, (ii) N-terminal amino acid sequencing, and (iii) mass spectrometry. In NLF from healthy subjects, the levels of immunoglobulin A increased and the levels of Clara cell protein 16 (CC16) decreased after chamber exposure, while in NLF from epoxy workers, α2-macroglobulin and caeruloplasmin increased. Two previously unidentified proteins decreased in NLF from epoxy workers after exposure, these were identified as statherin and calgranulin B. In addition, the subjects who developed high counts of eosinophils in their nasal mucosa after chamber exposure had significantly lower levels of immunoglobulin-binding factor (IgBF) before exposure than subjects with low eosinophil infiltration. These results show that short-term exposure to DMBA causes distinct changes in NLF proteins. Moreover, three proteins that have previously not been associated with upper airway irritation were identified: statherin, calgranulin B and IgBF. Further studies are needed to investigate whether these proteins may be used as biomarkers of airway irritation and to give new insight into the ways in which occupational exposure to irritants causes inflammation of the airways.
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| 38. |
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| 39. |
- Lindahl, Odd, et al.
(författare)
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Toxicity of Dinophysis spp. in relation to population density and environmental conditions on the Swedish west coast
- 2007
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Ingår i: Harmful Algae. - 1568-9883. ; 6:2, s. 218-231
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study in the field was to investigate whether there are differences between the outer archipelago (Gullmar Fjord) and a semi-enclosed fjord system (Koljo Fjord) in occurrences of D. acuta and D. acuminata as well as in their content of diarrheic shellfish toxin (DST) per cell. When all data pairs of cell toxicity of D. acuminata and the corresponding number of cells l(-1) from the two sites were tested in a regression analysis, a statistically significant negative correlation became evident and was apparent as a straight line on a log-log plot (p < 0.0001). Obviously, there was an overall inverse relationship between the population density of D. acuminata and the toxin content per cell. Plotted on a linear scale, all data-pairs of cell toxicity and cell number made up a parabolic curve. On this curve the data-pairs could be separated into three groups: (i) D. acuminata occurring in numbers of fewer than approximately 100 cells l(-1), and with a toxin content per cell above 5 rho g cell(-1); (ii) cell numbers between 100 and approximately 250 cells l(-1) with a cell toxin content from 5 to 2 rho g cell(-1); (iii) when the population became greater than 250 cells l(-1), the toxicity, with few exceptions, was less than 2 rho g cell(-1). By applying this subdivision, some clear patterns of the distribution of the differently toxic D. acuminata became evident. When comparing the cell toxicity of the two sites, it was obvious that the D. acuminata cells from all depths from the Gullmar Fjord as a mean were significantly more toxic compared to the Koljo Fjord samples. The results have demonstrated that approximately 100 high-toxicity cells in a low-density population at surface may lead to the same accumulation of DST in a mussel as the ingestion of 1500 low-toxicity cells from a high-density pycnocline population. (c) 2006 Elsevier B.V. All rights reserved.
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| 40. |
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