251. |
- Zhou, Wei, et al.
(författare)
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Global Biobank Meta-analysis Initiative : Powering genetic discovery across human disease
- 2022
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Ingår i: Cell Genomics. - : Elsevier. - 2666-979X. ; 2:10
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Tidskriftsartikel (refereegranskat)abstract
- Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.
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252. |
- Zhou, Zhenjiang, et al.
(författare)
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A 60-years old field experiment demonstrates the benefit of leys in the crop rotation
- 2019
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Ingår i: Acta Agriculturae Scandinavica, Section B - Soil and Plant Science. - : Informa UK Limited. - 0906-4710 .- 1651-1913. ; 69, s. 36-42
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Tidskriftsartikel (refereegranskat)abstract
- In the 1950s, a long-term experiment was initiated at three locations in Northern Sweden. The treatments included four cropping systems, which differed in the number of years with leys or annual crops in the crop rotation. To create awareness of the experiment as a research resource for further scientific studies, we summarise the history (experimental design, materials and methods, main measurements) and scientific findings of the experiment, as well as reflect on its usefulness and opportunities for further studies. So far, scientific focus has been on the effects of cropping systems on soil characteristics. The main findings indicate that soil porosity and hydraulic conductivity were greater in cropping systems with a large proportion of ley, soil bulk density showed the opposite trend. In terms of chemical properties, cropping systems incorporating more ley also have greater soil organic carbon content than annual crops systems, and both soil carbon and N storage decrease over time in cropping systems with only annual crops. The effects of cropping system on crop yields and quality are areas for further investigation.
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