| 21. |
- Cordtz, Rene Lindholm, et al.
(author)
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Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitors : a Nordic cohort study
- 2022
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In: RMD Open. - : BMJ Publishing Group Ltd. - 2056-5933. ; 8:2
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Journal article (peer-reviewed)abstract
- Objectives To evaluate the risk of haematological malignancies in patients with psoriatic arthritis (PsA) overall, and in relation to treatment with tumour necrosis factor inhibitors (TNFi).Methods We identified that patients with PsA starting a first TNFi from the clinical rheumatology registers (CRR) in the five Nordic countries (n=10 621) and biologics-naive PsA patients from (1) the CRR (n=18 705) and (2) the national patient registers (NPR, n=27 286, Sweden and Denmark) from 2006 through 2019. For Sweden and Denmark, general population comparators were matched 5:1 to PsA patients on birth year, year at start of follow-up and sex. By linkage to the national cancer registers in all countries, we collected information on haematological malignancies overall, and categorised into lymphoid or myeloid types. We estimated incidence rate ratios (IRRs) with 95% CIs using modified Poisson regression for TNFi-treated versus biologics-naive PsA patients and versus the general population adjusted for age, sex, calendar period and country.Results During 59 827 person-years, 40 haematological malignancies occurred among TNFi-treated patients with PsA resulting in a pooled IRR of 0.96 (0.68-1.35) versus biologics-naive PsA from CRR and an IRR of 0.84 (0.64-1.10) versus biologics-naive PsA from NPR. The IRR of haematological malignancies in PsA overall versus general population comparators was 1.35 (1.17-1.55). The estimates were largely similar for lymphoid and myeloid malignancies.Conclusions Treatment with TNFi in patients with PsA was not associated with an increased incidence of haematological malignancies. Conversely, a moderately increased underlying risk was seen in patients with PsA compared with the general population.
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| 22. |
- Dahlgren, Liselotte, et al.
(author)
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Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients.
- 2004
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 112:6, s. 1015-9
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Journal article (peer-reviewed)abstract
- The frequency of human papilloma virus (HPV) and its influence on clinical outcome was analyzed retrospectively in pre-treatment paraffin embedded biopsies from 110 patients with tongue cancer. The presence of HPV DNA was examined in 85 mobile tongue tumors and 25 base of tongue tumors by a polymerase chain reaction (PCR) with 2 general primer pairs, GP5+/6+ and CPI/IIG. When HPV-DNA was found, HPV-type specific primers and direct sequencing were used for HPV sub-type verification. Twelve of 110 (10.9%) samples were HPV-positive; 9 for HPV-16, 1 for HPV-33, 1 for HPV-35 and 1 could not be analyzed because of shortage of DNA. HPV was significantly more common in base of tongue tumors (10/25, 40.0%) compared to tumors of the mobile tongue (2/85, 2.3%). The influence of HPV on clinical outcome in mobile tongue cancer could not be studied, due to that HPV was present in too few cases. Of the 19 patients with base of tongue cancer that were included in the survival analysis, however, 7 patients with HPV-positive base of tongue cancer had a significantly favorable 5-year survival rate compared to the 12 HPV-negative patients. In conclusion, HPV is significantly more common in base of tongue cancer than in mobile tongue cancer, and has a positive impact on disease-specific survival in patients with base of tongue cancer.
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| 23. |
- Derlén, Mattias, 1976-, et al.
(author)
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Att bli jurist : råd för att lyckas och trivas på juristutbildningen
- 2020
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In: Vänbok till Ulf Israelsson. - Umeå : Juridiska institutionen, Umeå universitet. - 9789178553174 ; , s. 25-41
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Book chapter (other academic/artistic)abstract
- Ulf Israelsson, mångårig studierektor, medarbetare och juridiska institutionens primus motor, vet vad som krävs för att bli en bra jurist. Ulf har, bland mycket annat, bidragit till juristutbildningens kvalitetsarbete genom att utföra enkäter med studenter som tagit examen. I enkäten som genomfördes 2018 kommenterade en tidigare student att "[d]et var 4,5 fantastiska år där jag lärde mig otroligt mycket". Det är naturligtvis tillfredställande för alla oss som undervisar på juristprogrammet när en student är nöjd med sin utbildning, men det viktiga är den senare delen av citatet. Att bli jurist kräver mycket arbete. Nio terminers hårt arbete kommer också att förändra de som börjar programmet. Vissa går så långt som att hävda att många juriststudenter upplever en intellektuell pånyttfödelse under första året på utbildningen. Det är inte möjligt att i detta sammanhang beskriva alla de utmaningar som studenter på juristprogrammet kommer att möta, men vi har identifierat tre centrala aspekter som alla juriststudenter måste förhålla sig till. Studenterna måste för det första lära sig att prata som en jurist, för det andra att arbeta som en jurist och för det tredje att hantera andra juriststudenter. Det kommer inte att vara enkelt, men vi lovar att det är värt det.
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| 24. |
- Derlén, Mattias, 1976-, et al.
(author)
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Bosman : a legacy beyond sports
- 2016
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In: The legacy of Bosman. - Hague : T.M.C. Asser Press. - 9789462651197 - 9789462651203 ; , s. 31-49
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Book chapter (peer-reviewed)abstract
- The 1995 Bosman case from the CJEU is one of the most famous judgments ever delivered by the Luxembourg court. It is well-known in sporting contexts, but this article takes the discussion beyond that area, demonstrating Bosman's importance in other areas of law by using network analysis. This illustrates that Bosman is an exceptional case, both in its own right and as a source of further cases, citing Bosman directly or indirectly. We also demonstrate that Bosman is primarily cited for four reasons: the jurisdiction of the CJEU in matters of preliminary rulings, the use of the fundamental freedoms against private entities, non-discriminatory obstacles on the internal market and the temporal effects of CJEU judgments. However, when analyzed further it becomes clear that the Bosman case contains few truly original contributions to EU law and largely builds on existing case law to draw important conclusions. Thus, the Court must have other reasons for citing Bosman. Given the characteristics of the case many such reasons are plausible. Bosman is well-written, well-reasoned, well-known and well-connected, making it an excellent source to use in future cases.
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| 25. |
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| 26. |
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| 27. |
- Derlén, Mattias, 1976-, et al.
(author)
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Characteristics of Precedent : The Case Law of the European Court of Justice in Three Dimensions
- 2015
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In: German Law Journal. - 2071-8322. ; 16:5, s. 1073-1098
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Journal article (peer-reviewed)abstract
- The case law of the Court of Justice of the European Union (CJEU) is one of the most important sources of European Union law. However, case law’s role in EU law is not uniform. By empirically studying how the Court uses its own case law as a source of law, we explore the correlation between, on the one hand, the characteristics of a CJEU case— type of action, actors involved, and area of law—and, on the other hand, the judgment’s “embeddedness” in previous case law and value as a precedent in subsequent cases. Using this approach, we test, confirm, and debunk existing scholarship concerning the role of CJEU case law as a source of EU law. We offer the following conclusions: that CJEU case law cannot be treated as a single entity; that only a limited number of factors reliably affect a judgment’s persuasive or precedential power; that the Court’s use of its own case law as a source of law is particularly limited in successful infringement proceedings; that case law is particularly important in preliminary references—especially those concerning fundamental freedoms and competition law; and that initiating Member State and the number of observations affects the behavior of the Court.
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| 28. |
- Derlén, Mattias, 1976-, et al.
(author)
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Coherence out of chaos : mapping European union law by running randomly through the maze of CJEU case law
- 2013
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In: Europarättslig tidskrift. - Stockholm : Institutet för europarätt. - 1403-8722 .- 2002-3561. ; :3, s. 517-535
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Journal article (peer-reviewed)abstract
- Recent research has demonstrated the ability of network analysis to better understand law. In this study we apply network analysis to the case law of the European Court of Justice (CJEU) in order understand its role as a source of law. In doing so, we apply network analysis tools not previously used in legal scholarship, most significantly (i) a modified version of the PageRank algorithm, (ii) the Map Equation, and (iii) resampling to infer “missing” links. In the article we demonstrate that this method can help us to understand not only the CJEU’s case law but law generally.
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