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Träfflista för sökning "WFRF:(Ma Ronald C. W.) "

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21.
  • Gudbjartsson, Daniel F., et al. (author)
  • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
  • 2009
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41:3, s. 342-347
  • Journal article (peer-reviewed)abstract
    • Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
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  • Result 21-21 of 21
Type of publication
journal article (18)
research review (2)
other publication (1)
Type of content
peer-reviewed (20)
other academic/artistic (1)
Author/Editor
Ma, Ronald C W (11)
Groop, Leif (9)
McCarthy, Mark I (9)
Tuomilehto, Jaakko (9)
Peters, Annette (9)
Metspalu, Andres (9)
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Morris, Andrew P. (9)
Salomaa, Veikko (8)
Linneberg, Allan (8)
Mohlke, Karen L (8)
Hattersley, Andrew T (8)
Wong, Tien Yin (8)
Lindgren, Cecilia M. (8)
Wareham, Nicholas J. (7)
Mahajan, Anubha (7)
Froguel, Philippe (7)
Elliott, Paul (7)
Frayling, Timothy M (7)
Cheng, Ching-Yu (7)
Tai, E. Shyong (7)
So, Wing-Yee (7)
Tuomi, Tiinamaija (6)
Lind, Lars (6)
Franks, Paul W. (6)
Stancáková, Alena (6)
Kuusisto, Johanna (6)
Laakso, Markku (6)
Hansen, Torben (6)
Langenberg, Claudia (6)
Boehnke, Michael (6)
Scott, Robert A (6)
Locke, Adam E. (6)
Gieger, Christian (6)
Strauch, Konstantin (6)
Palmer, Colin N. A. (6)
Thorand, Barbara (6)
Loos, Ruth J F (6)
Morris, Andrew D (6)
Franco, Oscar H. (6)
Meisinger, Christa (6)
Prokopenko, Inga (6)
Aguilar-Salinas, Car ... (6)
Fischer, Krista (6)
Lim, Wei-Yen (6)
Collins, Francis S. (6)
Grallert, Harald (6)
Perry, John R.B. (6)
Chambers, John C. (6)
Kwak, Soo Heon (6)
Park, Kyong Soo (6)
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University
Lund University (15)
Uppsala University (11)
Umeå University (8)
University of Gothenburg (7)
Karolinska Institutet (6)
Högskolan Dalarna (3)
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Luleå University of Technology (2)
Halmstad University (1)
Stockholm University (1)
Örebro University (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
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Language
English (21)
Research subject (UKÄ/SCB)
Medical and Health Sciences (19)
Natural sciences (1)

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