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Sökning: WFRF:(Magnus MC)

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31.
  • Magnus, MC, et al. (författare)
  • Fetal death after the introduction of COVID-19 mitigation measures in Sweden, Denmark and Norway: a registry-based study
  • 2022
  • Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1, s. 20625-
  • Tidskriftsartikel (refereegranskat)abstract
    • It remains unclear whether the rate of fetal death has changed during the COVID-19 pandemic. We assessed the impact of COVID-19 mitigation measures on fetal death in Sweden (449,347 births), Denmark (290,857 pregnancies) and Norway (261,057 pregnancies) using robust population-based registry data. We used Cox regression to assess the impact of the implementation of pandemic mitigation measures on March 12th, 2020, on miscarriage (fetal loss before gestational week 22) and stillbirth (fetal loss after gestational week 22). A total of 11% of 551,914 pregnancies in Denmark and Norway ended in miscarriage, while the proportion of stillbirths among 937,174 births across the three countries was 0.3%. There was no difference in the risk of fetal death during the year following pandemic mitigation measures. For miscarriage, the combined hazard ratio (HR) for Norway and Denmark was 1.01 (95% CI 0.98, 1.03), and for stillbirth, the combined HR for all three countries was 0.99 (95% CI 0.89, 1.09). We observed a slightly decreased risk of miscarriage during the first 4 months, with an HR of 0.94 (95% CI 0.90, 0.99) after lockdown. In conclusion, the risk of fetal death did not change after the implementation of COVID-19 pandemic mitigation measures in the three Scandinavian countries.
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34.
  • Marinovich, ML, et al. (författare)
  • Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: protocol for an international cohort study
  • 2019
  • Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 9:1, s. e027941-
  • Tidskriftsartikel (refereegranskat)abstract
    • Short interpregnancy interval (IPI) has been linked to adverse pregnancy outcomes. WHO recommends waiting at least 2 years after a live birth and 6 months after miscarriage or induced termination before conception of another pregnancy. The evidence underpinning these recommendations largely relies on data from low/middle-income countries. Furthermore, recent epidemiological investigations have suggested that these studies may overestimate the effects of IPI due to residual confounding. Future investigations of IPI effects in high-income countries drawing from large, population-based data sources are needed to inform IPI recommendations. We aim to assess the impact of IPIs on maternal and child health outcomes in high-income countries.Methods and analysisThis international longitudinal retrospective cohort study will include more than 18 million pregnancies, making it the largest study to investigate IPI in high-income countries. Population-based data from Australia, Finland, Norway and USA will be used. Birth records in each country will be used to identify consecutive pregnancies. Exact dates of birth and clinical best estimates of gestational length will be used to estimate IPI. Administrative birth and health data sources with >99% coverage in each country will be used to identify maternal sociodemographics, pregnancy complications, details of labour and delivery, birth and child health information. We will use matched and unmatched regression models to investigate the impact of IPI on maternal and infant outcomes, and conduct meta-analysis to pool results across countries.Ethics and disseminationEthics boards at participating sites approved this research (approval was not required in Finland). Findings will be published in peer-reviewed journals and presented at international conferences, and will inform recommendations for optimal IPI in high-income countries. Findings will provide important information for women and families planning future pregnancies and for clinicians providing prenatal care and giving guidance on family planning.
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36.
  • Mc Carthy, Rebecka, et al. (författare)
  • Early root development of poplars (Populus spp.) in relation to moist and saturated soil conditions
  • 2018
  • Ingår i: Scandinavian Journal of Forest Research. - : Informa UK Limited. - 0282-7581 .- 1651-1891. ; 33, s. 125-132
  • Tidskriftsartikel (refereegranskat)abstract
    • Poplars (Populus spp.) are among the fastest growing trees raised in temperate regions of the world. Testing of newly developed cultivars informs assessment of potential planting stock for local environments. Initial rooting by nine poplar clones was tested in moist and saturated soil conditions during an 18-day greenhouse experiment. Clones responded differently to soil moisture, particularly in number of roots, root distribution, and root dry mass accumulation. About 73% of cuttings planted in moist soil produced roots from callus tissue, whereas only 1% of cuttings planted in saturated soil developed such roots. This drove root distribution towards the basal section of cuttings in moist soil, while in saturated soil roots were more evenly distributed among all three below-ground sections of cuttings. Roots originating from the basal section of cuttings planted in moist soil were longer than roots originating from apical and middle sections. Conversely, roots from the apical and middle sections of cuttings planted in saturated soil were longer than those originating from the basal section. Initial rooting among poplar clones established under two soil moisture regimes has implications for genotype deployment in the field, but long-term effects in the field are still unknown.
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37.
  • Mc Carthy, Rebecka, et al. (författare)
  • Reliability of stump sprouting as a regeneration method for poplars: clonal behavior in survival, sprout straightness and growth
  • 2014
  • Ingår i: Silva Fennica. - : Finnish Society of Forest Science. - 0037-5330 .- 2242-4075. ; 48
  • Tidskriftsartikel (refereegranskat)abstract
    • The interest in poplars (Populus spp.) has increased globally as a result of the current incentive to expand the use of biomass for energy. So far, knowledge about poplar stump sprouting is generally poor. The objective of this study was to investigate poplar stump sprouting as regeneration method in harvested plantations. A 19-year-old poplar clonal test, including 23 different clones, on former arable land was harvested in the winter. After one year, stumps were assessed for sprout survival, sprout straightness, number of sprouts, sprout height and basal diameter. Differences between clones were found for survival and sprout straightness. Clonal differences were also found in mean size of sprouts (basal diameter and height). However, no differences were found between clones when comparing size of the tallest sprout or number of sprouts produced on stumps. This study indicates that stump sprouts from various poplar clones differ in survival, sprout straightness and mean growth, which should be taken into account when planning for the next tree generation. The study needs to be complemented with other studies to better assess sprouting characteristics for different clones.
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38.
  • Menditto, Enrica, et al. (författare)
  • Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study
  • 2019
  • Ingår i: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 49:4, s. 442-460
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
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