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| 52. |
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| 53. |
- Maher, A., et al.
(författare)
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Solubility of the metastable polymorph of piracetam (Form II) in a range of solvents
- 2012
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Ingår i: Journal of Chemical and Engineering Data. - : American Chemical Society (ACS). - 0021-9568 .- 1520-5134. ; 57:12, s. 3525-3531
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Tidskriftsartikel (refereegranskat)abstract
- The solid-liquid solubility of the polymorph known as Form II of 2-oxo-1-pyrolidine acetamide (Piracetam) has been determined gravimetrically in different solvents. Form II is the metastable polymorph of piracetam at ambient conditions and has been isolated and characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Monitoring the solution concentration and the polymorphic composition of the solid phase displayed that this metastable form has a sufficient lifetime when in contact with the solvents to allow measurement of its solubility over the temperature range (278 to 323) K. Four solvents are included: ethanol, 2-propanol, acetone, and 1,4-dioxane. The results show that the solubility of Form II increases with increasing solvent polarity and solvent acidity. Form II has a slightly higher solubility than the stable Form III in all solvents at all temperatures, but the solubility difference is very small. Since Form II is known to transform to Form I below its melting point, a set of regression equations which can be used to extrapolate solubility data to the melting point of Form II were applied to the collected data.
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| 54. |
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| 55. |
- Meehan, A. J., et al.
(författare)
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The International Collaboration of Orthopaedic Nursing: advancing nursing through technology
- 2015
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Ingår i: International Nursing Review. - : Wiley. - 0020-8132 .- 1466-7657. ; 62:2, s. 203-206
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Tidskriftsartikel (refereegranskat)abstract
- AimTo report on the International Collaboration of Orthopaedic Nursing, a mostly virtual network of orthopaedic nursing organizations across four continents. BackgroundFormed by leaders of three national associations, the collaboration is based on recognition of patient problems and challenges shared by orthopaedic nurses globally. Methods/InitiativesThe Collaboration provides a range of services including education, mentoring, and organizational development. Low cost internet-based technologies, such as email and Skype, support global networking in real time. Discussion/Implications for Nursing and Health PolicyThe Collaboration is a cost effective example of how nurses can collaborate internationally to promote the highest standards of orthopaedic nursing.
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| 56. |
- Nopchinda, Dhecha, 1991, et al.
(författare)
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Dual Polarization Coherent Optical Spectrally Efficient Frequency Division Multiplexing
- 2015
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Ingår i: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 28:1, s. 83-86
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Tidskriftsartikel (refereegranskat)abstract
- A new optical spectrally efficient frequency division multiplexing technique, utilizing coherent detection and polarization division multiplexing, is proposed and demonstrated. The proposed system uses non-orthogonal and overlapping subcarriers to provide a significant reduction in both the electrical and optical bandwidth of up to 33%, relative to dual polarization orthogonal frequency division multiplexing (DP-OFDM), with an implementation penalty
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| 59. |
- Ray, K. K., et al.
(författare)
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EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study
- 2021
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 28:11, s. 1279-1289
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Tidskriftsartikel (refereegranskat)abstract
- Aims To provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement. Methods and results An 18 country, cross-sectional, observational study of patients prescribed LLT for primary or secondary prevention in primary or secondary care across Europe. Between June 2017 and November 2018, data were collected at a single visit, including LLT in the preceding 12 months and most recent LDL-C. Primary outcome was the achievement of risk-based 2016 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) LDL-C goal while receiving stabilized LLT; 2019 goal achievement was also assessed. Overall, 5888 patients (3000 primary and 2888 secondary prevention patients) were enrolled; 54% [95% confidence interval (CI) 52-56] achieved their risk-based 2016 goal and 33% (95% CI 32-35) achieved their risk-based 2019 goal. High-intensity statin monotherapy was used in 20% and 38% of very high-risk primary and secondary prevention patients, respectively. Corresponding 2016 goal attainment was 22% and 45% (17% and 22% for 2019 goals) for very high-risk primary and secondary prevention patients, respectively. Use of moderate-high-intensity statins in combination with ezetimibe (9%), or any LLT with PCSK9 inhibitors (1%), was low; corresponding 2016 and 2019 goal attainment was 53% and 20% (ezetimibe combination), and 67% and 58% (PCSK9i combination). Conclusion Gaps between clinical guidelines and clinical practice for lipid management across Europe persist, which will be exacerbated by the 2019 guidelines. Even with optimized statins, greater utilization of non-statin LLT is likely needed to reduce these gaps for patients at highest risk.
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