| 491. |
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| 492. |
- Ask, S., et al.
(författare)
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Luminosity measurement at ATLAS - Development, construction and test of scintillating fibre prototype detectors
- 2006
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 568:2, s. 588-600
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Tidskriftsartikel (refereegranskat)abstract
- We are reporting about a scintillating fibre tracking detector which is proposed for the precise determination of the absolute luminosity of the CERN LHC at interaction point 1 where the ATLAS experiment is located. The detector needs to track protons elastically scattered under mu rad angles in direct vicinity to the LHC beam. It is based on square shaped scintillating plastic fibres read out by multianode photomultiplier tubes and is housed in Roman Pots. We describe the design and construction of prototype detectors and the results of a beam test experiment at DESY. The excellent detector performance established in this test validates the detector design and supports the feasibility of the proposed challenging method of luminosity measurement. (c) 2006 Elsevier B.V. All rights reserved.
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| 493. |
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| 494. |
- Galon, Jerome, et al.
(författare)
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Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
- 2014
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Ingår i: Journal of Pathology. - : Wiley-Blackwell. - 0022-3417 .- 1096-9896. ; 232:2, s. 199-209
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Forskningsöversikt (refereegranskat)abstract
- The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune).
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| 495. |
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| 496. |
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| 497. |
- Mapelli, A., et al.
(författare)
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Development of a detector (ALFA) to measure the absolute LHC luminosity at ATLAS
- 2008
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Ingår i: Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 10th Conference. - 9812819088 - 9789812819086 ; , s. 984-988
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Konferensbidrag (refereegranskat)abstract
- The ATLAS collaboration plans to determine the absolute luminosity of the CERN LHC at Interaction Point 1 by measuring the trajectory of protons elastically scattered at very small angles (μrad). A scintillating fibre tracker system called ALFA (Absolute Luminosity For ATLAS) is proposed for this measurement. Detector modules will be placed above and below the LHC beam axis in roman pot units at a distance of 240 m on cach side of the ATLAS interaction point. They allow the detectors to approach the beam axis to millimeter distance. Overlap detectors also based on the scintillating fibre technology, will measure the precise relative position of the two detector modules, Results obtained during beam tests at DESY and at CERN validate the detectors design and demonstrate the achievable resolution. We also report about radiation hardness studies of the scintillating fibres to estimate the lifetime of the ALFA system at different operating conditions of the LHC.
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| 498. |
- Scaffaro, R., et al.
(författare)
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Advanced piezoresistive sensor achieved by amphiphilic nanointerfaces of graphene oxide and biodegradable polymer blends
- 2018
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Ingår i: Composites Science And Technology. - : Elsevier. - 0266-3538 .- 1879-1050. ; 156, s. 166-176
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Tidskriftsartikel (refereegranskat)abstract
- This work focuses on the preparation of a piezoresistive sensor device, by exploiting an amphiphilic sample of graphene oxide (GO) as a compatibilizer for poly (lactic acid) (PLA)-Poly (ethylene-glycol) (PEG) blends. The presence of GO determined a high stiffening and strengthening effect, without affecting toughness, and allowed a good stability of mechanical properties up to 40 days. Moreover, GO endowed the materials with electrical properties highly sensitive to pressure and strain variations: the biodegradable pressure sensor showed a responsivity of 35 μA/MPa from 0.6 to 8.5 MPa, a responsivity around 19 μA/MPa from 8.5 to 25 MPa. For lower pressure values (around 0.16–0.45 MPa), instead, the responsivity increases up to 220 μA/MPa in terms of ΔI/ΔP (i.e. (ΔI/ΔI0)/P close to 1 kPa−1). Furthermore, this novel sensor is able to monitor submicrometric displacements with an impressive sensitivity (up to 25 μA/μm in terms of ΔI/ΔL, or 70 in terms of (ΔI/I0)/ε). We implemented a model able to predict pressure changes up to 25 MPa, by monitoring and measuring variations in electrical conductivity, thus paving the road to use these biodegradable, ecofriendly materials as low-cost sensors for a large pressure range.
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| 499. |
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| 500. |
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