| 21. |
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| 22. |
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| 23. |
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| 24. |
- Hagbert, Pernilla, Dr, 1986-, et al.
(författare)
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Futures Beyond GDP Growth : Final report from the research program 'Beyond GDP Growth: Scenarios for sustainable building and planning'
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A future society no longer based on economic growth – what would that look like?The research program “Beyond GDP Growth: Scenarios for sustainable building and planning” (www.bortombnptillvaxt.se) is a strong research environment funded by the Swedish Research CouncilFormas, which has run between 2014 and 2018. In collaboration with societal partners, the program hasgathered researchers from diferent disciplines to explore key issues and conditions for planning for asustainable future beyond GDP growth. This is a relevant contribution to a largely under-researchedarea, where few scientific studies have explored what a sustainable society could look like, and what asustainable economy that is not based on growth might actually mean.In economic and political discussions, the notion of continuous economic growth is often taken forgranted and seen as a prerequisite for a safe and sustainable societal development. At the same time,a blind faith in and expectations surrounding growth can constitute a threat to the development of asustainable society if growth declines. Also an optimistic prognosis from the OECD indicates that it islikely that future GDP growth will be lower than what has come to be seen as the normal level duringthe second half of the 20th century. Declining economic growth could mean risks for increased socialgaps and unemployment. However, economic models show that the possibilities for handling these risksincrease if there is an awareness of them, and if this is addressed politically. Therefore, it is important tonot just assume continued economic growth, but to plan also for alternative scenarios.A starting point for the research program has been an understanding of the significant transitionsneeded to approach a safe and just operating space for humanity within planetary boundaries. Fourgoals that should be met in order to consider the societal development sustainable were specified: twoenvironmental goals related to climate and land use, and two social goals regarding power, influence andparticipation, and welfare and resource security.Four scenarios for Sweden 2050 were developed, which show the diferent directions society could taketo reach the set sustainability goals. The scenarios illustrate future societies that do not have to build onthe current economic logic, but that instead are centred around four alternative strategies:Collaborative EconomyLocal Self-SufciencyAutomation for Quality of LifeCircular Economy in the Welfare StateSo, can we reach the selected sustainability targets in the four future scenarios? A transformation ofhistorical proportions are needed – and it needs to start immediately. According to the sustainabilityassessment conducted within the project, the environmental goals of climate and land use can be reachedin all scenarios, even though it demands changing multiple parameters at the same time. Nothing pointsto it being impossible or generally difcult to achieve the social goals in the four scenarios, however theremight be diferent aspects that are particularly tricky. There are both development potentials and risks,which can be diametrically opposite for diferent social groups and parts of the country, depending onthe local prerequisites.Many diferent images of sustainable futures are needed. The scenarios should be seen as a tool fordiscussion and analysis when it comes to planning for a sustainable societal development beyondGDP growth. They challenge notions of what is possible, what changes that can and should be made,6what decisions that are needed and what should be prioritized. The scenarios all suggest a largechange compared the current development trajectory, and for example all point towards the need forredistribution of resources. It might involve economic resources, but could also relate to power andinfluence over production, or the possibility to use land for production of food, materials and energy.This redistribution could happen according to diferent principles in the diferent scenarios.In all the scenarios, the consumption of goods and of meat is reduced. Flight travel also needs to bedrastically reduced to reach the climate target. There is furthermore a need for reducing the constructionof both housing and road infrastructure, although to varying extents in the four scenarios. Other aspectssuch as working hours, the organization of welfare systems, the characteristics of the built environmentand the amount of infrastructure needed are on the other hand diferent in the diferent scenarios.The research program has explored what a development that isn't based on economic growth, in linewith the strategies that are depicted in the scenarios, would mean for rural as well as urban conditions.Three case study municipalities were selected with regards to their diferent geographical location,built form, economic development and size of the population: Övertorneå, Alingsås and Malmö. Insome sub-studies in these diferent contexts, descriptions emerged of cognitive as well as structuralbarriers, a sense of powerlessness and a weak capacity for transition among diferent actors. This isconnected to expectations and general assumptions regarding growth, partly irrespective of the context.Municipalities and companies to a large extent plan for and expect a societal development that buildsupon a further expansion of infrastructure, transport and consumption. Despite visions for sustainabledevelopment, in practice this often leads to a reproduction of current unsustainable structures and waysof life.At the same time, specific empirical studies within the project point toward stories of self-sufciency,of regional upswings and that the population is more important than GDP. There is an increasedawareness and a multitude of examples of experimenting with new sustainable practices that constituteseeds for change. Critiques against planning for continuous growth is being taken more seriously andclearer political visions are demanded. New forms of organizing the economy, society and welfare arealso being developed. Some examples include working from a perspective on socio-ecological justice,integration of sustainability targets in all planning, and developing new roles for consumers andproducers. These ideas can be seen as windows of opportunity, but also show that change can happenwithin the current system.The future means change. In this research program, we point towards some possible futures that aimat reaching certain sustainability targets. The scenarios and the discussion and analysis that they havebrought about show that there is an opportunity to move towards a sustainable development withmaintained or even increased well-being – provided that the understanding of well-being is based onother values than those of our current society. For these possible future trajectories to gain support,there is a need of political instruments and measures that actively drive the development towards a justand safe operating space for humanity
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| 25. |
- Hallberg, Pär, et al.
(författare)
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B2 bradykinin receptor (B2BKR) polymorphism and change in left ventricular mass in response to antihypertensive treatment : results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial
- 2003
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 21:3, s. 621-4
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Hypertension is associated with a number of adverse morphologic and functional changes in the cardiovascular system, including left ventricular (LV) hypertrophy. Studies have demonstrated that bradykinin, through the B2 bradykinin receptor (B2BKR), mediates important cardiovascular effects that may protect against LV hypertrophy. Recently, a +9/-9 exon 1 polymorphism of the B2BKR was shown to be strongly associated with LV growth response among normotensive males undergoing physical training. We aimed to clarify whether the processes found in exercise-induced LV growth in normotensive people also occur in pathological LV hypertrophy. DESIGN AND METHODS: We determined the B2BKR genotype of 90 patients with essential hypertension and echocardiographically diagnosed LV hypertrophy, included in a double-blind study to receive treatment for 48 weeks with either the angiotensin II type 1 (AT1) receptor antagonist irbesartan or the beta1-adrenoceptor antagonist atenolol. RESULTS: B2BKR +9/+9 genotypes responded poorly in LV mass regression, independent of blood pressure reduction or treatment, as compared to the other genotypes (adjusted mean change in LV mass index = -10.0 +/- 4.6 versus -21.6 +/- 2.2 g/m2, P = 0.03). CONCLUSIONS: Our results suggest an impact of the B2BKR polymorphism on LV mass regression during antihypertensive treatment.
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| 26. |
- Hallberg, Pär, et al.
(författare)
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The CYP2C9 genotype predicts the blood pressure response to irbesartan : results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial
- 2002
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 20:10, s. 2089-2093
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The cytochrome P450 CYP2C9 enzyme (CYP2C9) metabolizes many clinically important drugs, for example, phenytoin, warfarin and the angiotensin II type 1 (AT(1)) receptor antagonists, losartan and irbesartan. Single nucleotide polymorphisms in the CYP2C9 gene result in the expression of three important variants, CYP2C9*1(wild-type), CYP2C9*2 and CYP2C9*3, the last two exhibiting reduced catalytic activity compared with the wild-type. The CYP2C9 genotype is known to determine sensitivity to and dose requirements for both warfarin and phenytoin, and also the rate of metabolism of losartan. However, its influence on clinical response to treatment with the AT(1) receptor antagonist, irbesartan, has not been investigated. OBJECTIVE: To determine whether the CYP2C9genotype influences the blood pressure-decreasing response to antihypertensive treatment with irbesartan. DESIGN AND METHODS: One hundred and two patients with essential hypertension and left ventricular hypertrophy were allocated randomly to groups to receive double-blind treatment with either irbesartan (n = 49) or the beta(1)-adrenergic receptor blocker, atenolol ( n= 53). Blood pressure was measured before and after 12 weeks of treatment. genotyping was performed using solid-phase minisequencing. RESULTS: The diastolic blood pressure (DBP) response differed in relation to the CYP2C9 genotype in patients given irbesartan: the reduction in patients with genotype CYP2C9*1/CYP2C9*1 (n = 33) was 7.5% and that with CYP2C9*1/CYP2C9*2 (n = 12) was 14.4% ( P= 0.036). A similar trend was seen for systolic blood pressure. In contrast, no relation was seen between the CYP2C9 genotype and blood pressure response to atenolol, a drug not metabolized via CYP2C9. CONCLUSIONS: The CYP2C9 genotype seems to predict the DBP response to irbesartan, but not to atenolol, in patients with essential hypertension.
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| 27. |
- Hallberg, Pär, et al.
(författare)
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Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment : results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
- 2004
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 27:3, s. 169-73
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Angiotensin II, via the angiotensin II type 1 (AT1) receptor, may mediate myocardial fibrosis and myocyte hypertrophy seen in hypertensive left ventricular (LV) hypertrophy through production of transforming growth factor beta1 (TGF-beta1); AT1-receptor antagonists reverse these changes. The TGF-beta1 G + 915C polymorphism is associated with interindividual variation in TGF-beta1 production. No study has yet determined the impact of this polymorphism on the response to antihypertensive treatment. HYPOTHESIS: We aimed to determine whether the TGF-beta1 G + 915C polymorphism was related to change in LV mass during antihypertensive treatment with either an AT1-receptor antagonists or a beta1-adrenoceptor blocker. The polymorphism was hypothesized to have an impact mainly on the irbesartan group. METHODS: We determined the association between the TGF-beta1 genotype and regression of LV mass in 90 patients with essential hypertension and echocardiographically diagnosed LV hypertrophy, randomized in a double-blind study to receive treatment for 48 weeks with either the AT1-receptor antagonist irbesartan or the beta1-adrenoceptor blocker atenolol. RESULTS: Irbesartan-treated patients who were carriers of the C-allele, which is associated with low expression of TGF-beta1, responded with a markedly greater decrease in LV mass index (LVMI) than subjects with the G/G genotype (adjusted mean change in LVMI -44.7 g/m2 vs. -22.2 g/m2, p = 0.007), independent of blood pressure reduction. No association between genotype and change in LVMI was observed in the atenolol group. CONCLUSIONS: The TGF-beta1 G + 915C polymorphism is related to the change in LVMI in response to antihypertensive treatment with the AT1-receptor antagonist irbesartan.
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| 28. |
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| 29. |
- Hjort, Marcus, et al.
(författare)
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Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries
- 2019
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Ingår i: Clinical Chemistry. - : AMER ASSOC CLINICAL CHEMISTRY. - 0009-9147 .- 1530-8561. ; 65:8, s. 1023-1030
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD).METHODS: Ninety-one biomarkers were measured with a proximity extension assay 3 months after MI in 97 MINOCA patients, 97 age-and sex-matched MI-CAD patients, and 98 controls. Lasso analyses (penalized logistic regression models) and adjusted multiple linear regression models were used for statistical analyses.RESULTS: In the Lasso analysis (MINOCA vs MI-CAD), 8 biomarkers provided discriminatory value: P-selectin glycoprotein ligand 1, C-X-C motif chemokine 1, TNF-related activation-induced cytokine, and pappalysin-1 (PAPPA) with increasing probabilities of MINOCA, and tissue-type plasminogen activator, B-type natriuretic peptide, myeloperoxidase, and interleukin-1 receptor antagonist protein with increasing probabilities of MI-CAD. Comparing MINOCA vs controls, 7 biomarkers provided discriminatory value: N-terminal pro-B-type natriuretic peptide, renin, NF-kappa-B essential modulator, PAPPA, interleukin-6, and soluble urokinase plasminogen activator surface receptor with increasing probabilities of MINOCA, and agouti-related protein with increasing probabilities of controls. Adjusted multiple linear regression analyses showed that group affiliation was associated with the concentrations of 7 of the 8 biomarkers in the comparison MINOCA vs MI-CAD and 5 of the 7 biomarkers in MINOCA vs controls.CONCLUSIONS: Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts.
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| 30. |
- Högfeldt, Anna-Karin, et al.
(författare)
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Program leadership from a nordic perspective : Program leaders' power to influence their program
- 2013
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Ingår i: Proceedings of the 9th International CDIO Conference.
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Konferensbidrag (refereegranskat)abstract
- In this paper a continuation research at five technical universities in Nordic countries (N5T network) in 2012 is presented, wheretheaim was to find out how the program leadersconceived their function, role and mandate, and the work situations between the universitieswere compared. The previous research demonstrated that programleadershave quite different positions, strategies and methods when it comes to monitoring and developing their programs.In this paper, a deeper investigationis carried out ofthe (im-) possibilitiesto make realinfluence on the study courses that constitutesthe respective Engineering study programs. Eightprogram leaders from thefiveN5Tuniversities have been interviewed, and theanalysis of these studies, has culminatedina model for the analysis of program leadership for Engineering educationdevelopment.
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