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- El Khoury, A, et al.
(författare)
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Decreased plasma prolactin release in euthymic lithium-treated women with bipolar disorder
- 2003
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Ingår i: Neuropsychobiology. - : S. Karger AG. - 0302-282X .- 1423-0224. ; 48:1, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- In order to evaluate the effect of treatment with citalopram (CIT) and lithium (Li) on hormone levels in women with bipolar disorder, morning plasma prolactin (PRL) and cortisol (CORT) were measured in 14 nonmedicated depressed patients, 13 depressed patients responding to CIT treatment, 17 euthymic patients on long-term Li treatment, and 11 healthy controls. Plasma PRL values in the Li group were significantly lower than those of the three other groups, suggesting a net inhibitory impact of augmentative effects of Li on dopaminergic activity and serotonergic neurotransmission in the central nervous system. Plasma CORT values in nonmedicated depressed patients were significantly higher than those of healthy controls, indicating hyperactivity of the hypothalamic-pituitary-adrenal system in depression, which appears to be a state-dependent phenomenon, and is normalized upon successful treatment with Li and CIT.
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17. |
- Pereira, H. A., et al.
(författare)
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Capacitor voltage balance performance comparison of MMC-STATCOM using NLC and PS-PWM strategies during negative sequence current injection
- 2016
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Ingår i: 18th European Conference on Power Electronics and Applications, EPE 2016 ECCE Europe, Karlsruhe, Germany, 5-9 September 2016. - 2325-0313. - 9789075815245
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Konferensbidrag (refereegranskat)abstract
- This paper addresses the modular multilevel converter applied as a static synchronous compensator. The main objective of this work is to compare the converter performance considering two different submodule capacitor voltage balancing strategies: nearest level control and phase-shifted pulse width modulation, during positive and negative sequence current injection. Results of a 15 MVA MMC STATCOM show that the nearest level control strategy has lower average switching frequency compared to the phase-shifted pulse width modulation strategy, considering comparable submodule capacitance voltage ripple.
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19. |
- Sheils, T. K., et al.
(författare)
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TCRD and Pharos 2021: mining the human proteome for disease biology
- 2021
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 49:D1, s. D1334-D1346
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Tidskriftsartikel (refereegranskat)abstract
- In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecules or biologics. Two resources produced from these efforts are: The Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/) and Pharos (https://pharos.nih.gov/), a web interface to browse the TCRD. The ultimate goal of these resources is to highlight and facilitate research into currently understudied proteins, by aggregating a multitude of data sources, and ranking targets based on the amount of data available, and presenting data in machine learning ready format. Since the 2017 release, both TCRD and Pharos have produced two major releases, which have incorporated or expanded an additional 25 data sources. Recently incorporated data types include human and viral-human protein-protein interactions, protein-disease and protein-phenotype associations, and drug-induced gene signatures, among others. These aggregated data have enabled us to generate new visualizations and content sections in Pharos, in order to empower users to find new areas of study in the druggable genome.
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20. |
- Aghajanian, G. K., et al.
(författare)
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Torgny Svensson, M.D., Ph.D. (1945-2020)
- 2020
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Ingår i: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. - : Springer Science and Business Media LLC. - 1740-634X. ; 45:11
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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