| 51. |
- Mitchell, Jonathan S., et al.
(författare)
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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
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| 52. |
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| 53. |
- Nickel, D., et al.
(författare)
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Large-scale water resources management within the framework of GLOWA-Danube - The water supply model
- 2005
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Ingår i: Physics and Chemistry of the Earth. - : Elsevier BV. - 1474-7065. ; 30:6-7 SPEC. ISS., s. 383-388
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Tidskriftsartikel (refereegranskat)abstract
- The research project GLOWA-Danube, financed by the German Federal Government, investigates long-term changes in the water cycle of the upper Danube river basin in light of global climatic change. Its aim is to build a fully integrated decision support tool "DANUBIA" that combines the competence of eleven institutes in domains covering all major aspects governing the water cycle. The research group "Groundwater and Water Supply" at the Institute of Hydraulic Engineering (IWS), Universitaet Stuttgart, contributes a three-dimensional groundwater flow model and a large-scale water supply model which simulate both water availability and quality and water supply and the related costs for global change scenarios. This article addresses the task of creating an agent-based model of the water supply sector. The water supply model links the various physical models determining water quality and availability on the one hand and the socalled "Actor" models calculating water demand on the other by determining the actual water supply and the costs related, which underlie both technical and physical constraints (e.g., existing infrastructure and its capacity, water availability and quality, geology, elevation, etc.). In reality, water supply within the study is organised through a three-tiered structure: long-distance, regional, and a multitude of community-based suppliers. In order to model this system in which each supply company defines its own optimum, an agent-based modelling approach (implemented using JAVA) was chosen. This approach is novel to modelling water supply in that not only water supply infrastructure but more importantly the decision makers (communities, water supply companies) are represented as generalised objects, capable of performing actions following rules that are determined by the class they belong to. © 2005 Elsevier Ltd. All rights reserved.
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| 54. |
- Nickel, O, et al.
(författare)
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Evaluation of Simple Lateral Flow Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies
- 2022
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Ingår i: Vaccines. - : MDPI AG. - 2076-393X. ; 10:3
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Tidskriftsartikel (refereegranskat)abstract
- Immunization for the generation of protective antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged to be highly effective in preventing hospital admission, need for intensive care treatment and high mortality in the current SARS-CoV-2 pandemic. Lateral flow immune assays (LFIAs) offer a simple and competitive option to monitor antibody production after vaccination. Here, we compared the diagnostic performance of three different lateral flow assays in detecting nucleocapsid protein (NP), S1 subunit (S1) and receptor binding domain (pseudo)-neutralizing antibodies (nRBD) in sera of 107 health care workers prior (V1), two weeks (V2) after first vaccination with BNT162b2 as well as three weeks (V3) and eight months later (V4). In sera at V1, overall specificity was >99%. At V3, LFIAs showed sensitivities between 98.1 and 100%. The comparison of S1 and nRBD LFIA with S1 ELISA and a focus reduction neutralization assay (FRNT) revealed high concordance at V3. Thus, the use of lateral flow immunoassays appears to have reasonable application in the short-term follow-up after vaccination for SARS-CoV-2.
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| 55. |
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| 56. |
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| 57. |
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| 58. |
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| 59. |
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| 60. |
- Suliman, S., et al.
(författare)
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Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes
- 2016
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Ingår i: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 95, s. 11-21
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance osteoinductivity. Culturing early neoplastic dysplastic keratinocytes (DOKLuc) on nDP modified scaffolds reduced significantly their subsequent sphere formation ability and decreased significantly the cells' proliferation in the supra-basal layers of in vitro 3D oral neoplastic mucosa (3D-OT) when compared to DOKLuc previously cultured on nDP-PHY scaffolds. Using an in vivo non-invasive environmentally-induced oral carcinogenesis model, nDP scaffolds were observed to reduce bioluminescence intensity of tumours formed by DOKLuc + carcinoma associated fibroblasts (CAF). nDP modification was also found to promote differentiation of DOKLuc both in vitro in 3D-OT and in vivo in xenografts formed by DOKLuc alone. The nDP-PHY scaffold had the highest number of invasive tumours formed by DOKLuc + CAF outside the scaffold area compared to the nDP and control scaffolds. In conclusion, in vitro and in vivo results presented here demonstrate that nDP modified copolymer scaffolds are able to decrease the tumorigenic potential of DOKLuc, while confirming concerns for the therapeutic use of BMP-2 for reconstruction of bone defects in oral cancer patients due to its tumour promoting capabilities.
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