| 2671. |
- McGinn, Steven, et al.
(författare)
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New Technologies for DNA analysis-A review of the READNA Project.
- 2016
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Ingår i: New Biotechnology. - : Elsevier BV. - 1876-4347 .- 1871-6784.
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Forskningsöversikt (refereegranskat)abstract
- The REvolutionary Approaches and Devices for Nucleic Acid analysis (READNA) project received funding from the European Commission for 4 1/2 years. The objectives of the project revolved around technological developments in nucleic acid analysis. The project partners have discovered, created and developed a huge body of insights into nucleic acid analysis, ranging from improvements and implementation of current technologies to the most promising sequencing technologies that constitute a 3(rd) and 4(th) generation of sequencing methods with nanopores and in situ sequencing, respectively.
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| 2672. |
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| 2673. |
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| 2674. |
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| 2675. |
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| 2676. |
- Mege, D, et al.
(författare)
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Surgical management of esophageal sarcoma: a multicenter European experience
- 2018
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Ingår i: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. - : Oxford University Press (OUP). - 1442-2050. ; 31:3
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Tidskriftsartikel (refereegranskat)abstract
- Esophageal sarcomas are rare and evidence in literature is scarce making their management difficult. The objective is to report surgical and oncological outcomes of esophageal sarcoma in a large multicenter European cohort. This is a retrospective multicenter study including all patients who underwent en-bloc esophagectomy for esophageal sarcoma in seven European tertiary referral centers between 1987 and 2016. The main outcomes and measures are pathological results, early and long-term outcomes. Among 10,936 esophageal resections for cancer, 21 (0.2%) patients with esophageal sarcoma were identified. The majority of tumors was located in the middle (n = 7) and distal (n = 9) third of the esophagus. Neoadjuvant chemoradiotherapy was performed in five patients. All the patients underwent en-bloc transthoracic esophagectomy (19 open, 2 minimally invasive). Postoperative mortality occurred in 1 patient (5%). One patient received adjuvant chemotherapy. Definitive pathological results were carcinosarcoma (n = 7), leiomyosarcoma (n = 5), and other types of sarcoma (n = 9). Microscopic R1 resection was present in one patient (5%) and seven patients (33%) had positive lymph nodes. Median follow-up was 16 (3–79) months in 20 of 21 patients (95%). One-, 3-, and 5-year overall survival rates were 74%, 43%, and 35%, respectively. One-, 3- and 5-years disease-free survival rates were 58%, 40%, and 33%, respectively. Median overall survival was 6 months in N+ patients vs. 37 months for N0 patients (p = 0.06). At the end of the follow-up period, nine patients had died from cancer recurrences (43%), three patients died from other reasons (14%), one patient was still alive with recurrence (5%) and the seven remaining patients were free of disease (33%). Recurrence was local (n = 3), metastatic (n = 3), or both (n = 4). In conclusion, carcinosarcoma and leiomyosarcoma were the most common esophageal sarcoma histological subtypes. Lymph node involvement was seen in one third of cases. A transthoracic en-bloc esophagectomy with radical lymphadenectomy should be the best surgical option to achieve complete resection. Long-term survival remained poor with a high local and distant recurrence rate.
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| 2677. |
- Melin, L. Gunnar, et al.
(författare)
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A study of Mode-I delamination cracks by high-magnification moiré interferometry
- 1998
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Ingår i: Composites Science And Technology. - 0266-3538 .- 1879-1050. ; 58:3-4, s. 515-525
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Tidskriftsartikel (refereegranskat)abstract
- Delamination cracks in carbon-fibre/epoxy composites loaded in Mode-I have been studied by high-magnification moiré interferometry. The moiré interferometer has the capability of switching between laser illumination for acquiring the displacement field and white-light illumination for visualisation of the underlying microstructure. Four specimens with different stacking geometries have been investigated. The delamination cracks have been simulated by using Teflon films. The resulting displacement fields have been compared to numerical solutions calculated by the finite-element method. The comparisons indicate that the Teflon films for some of the specimens did not delaminate fully. Otherwise the agreement is good, confirming that the displacement field around such cracks is satisfactorily described by linear-elastic fracture mechanics. The agreement was improved when a matrix-rich region in front of the crack tip was included in the finite-element model.
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| 2678. |
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| 2679. |
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| 2680. |
- Méndez, Alexis, et al.
(författare)
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Packaging process of fiber Bragg grating strain sensors for use in high-temperature applications
- 2005
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Konferensbidrag (refereegranskat)abstract
- In this paper, we report the development of a new bonding agent and method for the surface mounting of optical fiber Bragg grating (FBG) strain and temperature sensors for use in high temperature environments--where there is a presence of water, moisture, dust, susceptibility to corrosion and/or elevated temperatures up to 800°C. To ensure a stable reflectivity response of FBGs and their survival at elevated temperatures, we are using chemical composition gratings (CCGs). The refractive index modulation in these gratings is caused by a chemical change, which results in a higher activation energy and stable behavior up to 1000°C. Samples of CCGs were successfully encapsulated and mounted onto metal shims. The packaged sensors were tested for strain (+/- 1000με) and temperature (to +400 °C) response. The encapsulated sensors display a linear response with an increase in the temperature sensitivity of the FBG, with a factor of ~ 28.34pm/°C, and a strain gauge factor of 1.7pm/με.
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