| 91. |
- Ohlsson, Jonas, 1980
(författare)
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The Practice of Newspaper Ownership: Fifty Years of Control and Influence in the Swedish Local Press
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation deals with a perennial theme in both public and academic debate: how ownership is exercised in the news media. It does so by exploring the main agency through which ownership control is expected to be exerted in the individual media firm: the board of directors. Establishing the board as an intermediary between owners and the executive and editorial management, the study addresses a number of questions pertaining to the role of media boards: who is elected to the boards; which decisions are made in the boardroom, and which are not; who influences them, and who does not. The empirical results come from a historical study of the Swedish newspaper industry. The Swedish press has long been characterized by close ties to the political arena. A more recent characteristic is the growing dominance of not-for-profit foundations as owners of newspapers. It is the consequence of this particular ownership form that is the main focus of the dissertation. The study analyzes the boards of three local, foundation-owned newspapers between 1955 and 2005. The newspapers are Barometern (Kalmar), Borås Tidning (Borås) and Sundsvalls Tidning (Sundsvall). The study builds primarily on two sources: minutes from over twelve-hundred board meetings and meetings of shareholders, and interviews with twenty-three former and current board members. The study shows that the governance processes, including both the role played by the individual board and the relative autonomy of the editorial department, have differed significantly between the three cases. The distinct characteristics have been reinforced not only by the fact that the newspapers are old and exceedingly mature institutions, but also as a result of a very slow circulation of members of the top echelons of the newspaper organizations. Consequently, the most noticeable shifts in the activities and power structures of the companies have followed from the entering of new decision-makers into the organizations. A basic conclusion is thus that there is no single answer concerning the ramifications of foundation ownership in the press. As a result of an increasingly competitive market situation, the companies have since the early 1990s nevertheless come to be increasingly dominated by professional managers and board members, making the traditional governance features less distinct. The process has been spurred by the fact that all three newspapers have been transformed from independents to parts of expanding newspaper groups. As a result, much of the allocative control previously enjoyed by the local boards has been transferred to central levels of the corporate hierarchy.
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| 92. |
- Ohlsson, Jonas, 1980
(författare)
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The Swedish media market
- 2014
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Ingår i: Media development 2014. - Stockholm : The Swedish Broadcasting Authority (Myndigheten för radio och tv). - 9789198048940 ; , s. 66-95
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 93. |
- Ohlsson, Jonas, 1980
(författare)
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Tidningen och demokratin
- 2013
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Ingår i: Bergström, Annika & Jonas Ohlsson (red) En region för alla? Medborgare, människor och medier i Västsverige. - Göteborg : SOM-institutet vid Göteborgs universitet. - 9789189673298 ; , s. 95-113
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 94. |
- Ohlsson, Jonas, 1980, et al.
(författare)
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Vanor och attityder i förändring
- 2013
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Ingår i: Vanor och attityder i förändring : samhälle, opinion och medier i Skåne / Jonas Ohlsson och Annika Bergström (red). - Göteborg : University of Gothenburg. - 9789189673267 ; , s. 9-27
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 95. |
- Ohlsson, Jonas, 1980
(författare)
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Ökade klyftor i nyhetsanvändningen
- 2013
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Ingår i: Vanor och attityder i förändring : samhälle, opinion och medier i Skåne / Jonas Ohlsson och Annika Bergström (red). - Göteborg : University of Gothenburg. - 9789189673267 ; , s. 131-148
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 96. |
- Ossenkoppele, Rik, et al.
(författare)
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Discriminative Accuracy of F-18 flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders
- 2018
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Ingår i: Jama-Journal of the American Medical Association. - : American Medical Association (AMA). - 0098-7484. ; 320:11, s. 1151-1162
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE The positron emission tomography (PET) tracer [F-18]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [F-18]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional study, 719 participants were recruited from 3 dementia centers in South Korea, Sweden, and the United States between June 2014 and November 2017 (160 cognitively normal controls, 126 patients with mild cognitive impairment [MCI], of whom 65.9% were amyloid-beta [A beta]positive [ie, MCI due to AD], 179 patients with AD dementia, and 254 patients with various non-AD neurodegenerative disorders). EXPOSURES The index testwas the [F-18]flortaucipir PET standardized uptake value ratio (SUVR) in 5 predefined regions of interest (ROIs). Cut points for tau positivity were determined using the mean +2 SDs observed in controls and Youden Index for the contrast AD dementia vs controls. MAIN OUTCOMES AND MEASURES The reference standard was the clinical diagnosis determined at the specialized memory centers. In the primary analysis, the discriminative accuracy (ie, sensitivity and specificity) of [F-18]flortaucipir was examined for AD dementia vs all non-AD neurodegenerative disorders. In secondary analyses, the area under the curve (AUC) of [F-18]flortaucipir SUVR was compared with 3 established magnetic resonance imaging measures (hippocampal volumes and AD signature and whole-brain cortical thickness), and sensitivity and specificity of [F-18]flortaucipir in MCI due to AD vs non-AD neurodegenerative disorders were determined. RESULTS Among 719 participants, the overall mean (SD) age was 68.8 (9.2) years and 48.4% were male. The proportions of patients who were amyloid-beta positive were 26.3%, 65.9%, 100%, and 23.8% among cognitively normal controls, patients with MCI, patients with AD dementia, and patients with non-AD neurodegenerative disorders, respectively. [F-18]flortaucipir uptake in the medial-basal and lateral temporal cortex showed 89.9% (95% CI, 84.6%-93.9%) sensitivity and 90.6%(95% CI, 86.3%-93.9%) specificity using the threshold based on controls (SUVR, 1.34), and 96.8%(95% CI, 92.0%-99.1%) sensitivity and 87.9%(95% CI, 81.9%-92.4%) specificity using the Youden Index-derived cutoff (SUVR, 1.27) for distinguishing AD dementia from all non-AD neurodegenerative disorders. The AUCs for all 5 [F-18]flortaucipir ROIs were higher (AUC range, 0.92-0.95) compared with the 3 volumetric MRI measures (AUC range, 0.63-0.75; all ROIs P<.001). Diagnostic performance of the 5 [F-18]flortaucipir ROIs were lower in MCI due to AD (AUC range, 0.75-0.84). CONCLUSIONS AND RELEVANCE Among patients with established diagnoses at a memory disorder clinic, [F-18]flortaucipir PET was able to discriminate AD from other neurodegenerative diseases. The accuracy and potential utility of this test in patient care require further research in clinically more representative populations.
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| 97. |
- Ramdas, S., et al.
(författare)
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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
- 2022
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 109:8, s. 1366-1387
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Tidskriftsartikel (refereegranskat)abstract
- A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
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| 98. |
- Sjøvaag, Helle, et al.
(författare)
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Media Ownership and Journalism
- 2019
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Ingår i: Oxford Research Encyclopedia of Communication. - Oxford : Oxford University Press.
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Bokkapitel (refereegranskat)abstract
- Media ownership is of interest to research on journalism due to the assumption that ownership can have an impact of the contents and practices of journalism. Ownership of news media take many forms: state ownership, family ownership, party ownership, trust ownership, public or corporate ownership. The main concern with ownership in journalism scholarship is market concentration and monopolization, and the undue effects this may have on media diversity, public opinion formation, democracy and journalistic autonomy. Throughout the research, ownership motivations are assumed to lie with the potential financial and political benefits of owning journalistic media. Benevolence is seldom assumed, as the problematic aspects of ownership are treated both from the management side of the research, and from the critical political economy perspective. News and journalism are largely understood as public goods, the quality of which is often seen as threatened by commercialism and market realities, under the economic aims of owners. However, the many forms and shapes that ownership of news media assume have different impacts on the competition between media outlets, the organization of editorial production, journalistic and professional cultures, and the intensity of corporate and profit maximizing philosophies that journalists work under. Ownership, however, assumes different forms in different media systems.
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| 99. |
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| 100. |
- Smith, Ruben, et al.
(författare)
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In vivo retention of (18)F-AV-1451 in corticobasal syndrome.
- 2017
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Ingår i: Neurology. - 1526-632X. ; 89:8, s. 845-853
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Tidskriftsartikel (refereegranskat)abstract
- To study the usefulness of (18)F-AV-1451 PET in patients with corticobasal syndrome (CBS).We recruited 8 patients with CBS, 17 controls, 31 patients with Alzheimer disease (AD), and 11 patients with progressive supranuclear palsy (PSP) from the Swedish BioFINDER study. All patients underwent clinical assessment, (18)F-AV-1451 PET, MRI, and quantification of β-amyloid pathology. A subset of participants also underwent (18)F-FDG-PET.In the 8 patients with CBS, 6 had imaging findings compatible with the corticobasal degeneration pathology and 2 with typical AD pathology. In the 6 patients with CBS without typical AD pathology, there were substantial retentions of (18)F-AV-1451 in the motor cortex, corticospinal tract, and basal ganglia contralateral to the most affected body side. These patients could be clearly distinguished from patients with AD dementia or PSP using (18)F-AV-1451. However, cortical atrophy was more widespread than the cortical retention of (18)F-AV1451 in these CBS cases, and cortical AV-1451 uptake did not correlate with cortical thickness or glucose hypometabolism. These results are in sharp contrast to AD dementia, where (18)F-AV-1451 retention was more widespread than cortical atrophy, and correlated well with cortical thickness and hypometabolism.Patients with CBS without typical AD pathology exhibited AV-1451 retention in the motor cortex, corticospinal tract, and basal ganglia contralateral to the affected body side, clearly different from controls and patients with AD dementia or PSP. However, cortical atrophy measured with MRI and decreased (18)F-fluorodeoxyglucose uptake were more widespread than (18)F-AV-1451 uptake and probably represent earlier, yet less specific, markers of CBS.This study provides Class III evidence that (18)F-AV-1451 PET distinguishes between CBS and AD or PSP.
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