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Sökning: WFRF:(Olsson Caroline 1970 )

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41.
  • Olsson, Caroline, 1970, et al. (författare)
  • Patient-reported genitourinary toxicity for long-term prostate cancer survivors treated with radiation therapy.
  • 2013
  • Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 108:10, s. 1964-70
  • Tidskriftsartikel (refereegranskat)abstract
    • Background:The objective of this study is to provide comprehensive overviews of patient-reported urinary symptoms for long-term prostate cancer survivors treated with radiation therapy and for untreated, healthy men.Methods:We performed a population-based cross-sectional study using a study-specific postal questionnaire assessing symptoms among 1007 men consecutively treated at the Sahlgrenska University Hospital, Göteborg, Sweden from 1993-2006 (primary or salvage external beam radiation therapy (EBRT) or EBRT and high-dose rate brachytherapy). We also randomly recruited 350 non-pelvic-irradiated matched control men from the Swedish Total Population Register. Symptom prevalence and prevalence ratios were computed.Results:Survey participation rate was 89% (874/985) for eligible survivors and 73% (243/332) for eligible controls. Median time from treatment to follow-up was 5 years (range, 1-14 years). Among the 21 investigated symptoms reflecting obstruction, frequency, urgency, pain and incontinence, we found significantly higher prevalence compared with controls for 9 symptoms in the EBRT group, 10 in the EBRT+brachytherapy group and 5 in the salvage EBRT group. The prevalence for a majority of the symptoms was stable over time.Conclusion:The presented toxicity profiles provide a thorough understanding of patient-reported urinary symptoms that can assist in developing personalised therapy for prostate cancer.
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44.
  • Olsson, Caroline, 1970 (författare)
  • Predicting Normal Tissue Complications after External Beam Radiation Therapy
  • 2010
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Although modern external beam radiation (EBRT) therapy has the ability to conform the dose tightly around the volume to be treated, unwanted irradiation to surrounding normal tissue is still a problem. The probability of a side effect arising in normal tissue after EBRT is commonly modelled by an s-shaped dose-volume response curve where dose or volume are plotted against response (i.e. the frequency with which the side effect occurs). The models are based on sigmoid mathematical functions and are fitted to input data representing the outcome (absence or presence of the studied symptom associated with the side effect) and the dose distribution for potentially injured organs using statistical methods. The purpose of this thesis is to give an overview of the current forms of outcome and dose data, how they are generated and used to model side effects today, some of their limitations, and potential future directions. The results are based on concepts from the literature as well as from the three appended papers. The first two present questionnaire-collected outcome data and 2D dose-volume histogram data of the pubic bone for 650 long-term gynecological cancer survivors treated with pelvic radiation therapy between 1991 and 2003 where one in every ten women reported pubic bone pain. The mean dose to the pubic bone proved critical for pain occurrence and the risk to experience pubic bone pain two or more years after pelvic radiation therapy is expected to be 5 % for a mean absorbed dose of 25 Gy. The third paper presents dose differences between non-corrected and fractionation-corrected combined doses in sequential two-phase treatments using 16 combined dose distributions over a model organ at risk (OAR) “irradiated” with a conventional fractionation schedule (2 Gy per fraction; 46 Gy + 22 Gy). Dose differences up to 6 Gy (50 % of a reference total dose
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45.
  • Olsson, Caroline, 1970 (författare)
  • Radiation Oncology Data and Modelling Side Effects after Radiation Therapy
  • 2012
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Although modern radiation therapy techniques have the ability to conform the dose distribution of ionizing radiation tightly around the volume to be treated, unwanted irradiation to surrounding organs remains a problem. The probability of a side effect arising in the normal tissue of a patient after radiation therapy can be modelled by sigmoid mathematical functions known as normal tissue complication probability (NTCP) models. Using statistical methods, these are fitted to input data representing the absence or presence of a studied symptom associated with the side effect in question and the dose distribution for potentially injured organs. NTCP models are increasingly being used in the clinic both for treatment evaluation and to guide optimization algorithms for inverse treatment planning although their predictions are associated with uncertainties to varying degrees. The purpose of this thesis is to investigate how different means to represent dose and ways to grade side effects contribute to uncertainties in radiation therapy side effect modelling. Using concepts from the literature and results from two recent Swedish studies including data on parotid gland complications in head and neck cancer patients and pubic bone pain in gynaecological cancer patients, respectively, current generations and representations of dose and side effect data and how these are used in modelling side effects are surveyed. Using similarities and differences in the data by the literature and these two studies, it is concluded that dose data for modelling purposes today is described by dose-volume histograms but can be made more detailed using a three-dimensional format like the structure-specific dose matrix as introduced in this thesis with additional information on dose representation. Side effect data are described by different scales to grade the same or similar symptoms, but also need to include information on factors which may influence modelling results such as effect-modifying factors as well as baseline symptom frequencies in non-irradiated individuals. Altogether, 15 items that capture the essential information needed for radiation therapy side effect modelling are identified, and the outlook for data integration and interoperability in radiation oncology would be improved by using these to form a semantic basis for this domain.
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46.
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47.
  • Olsson, Caroline, 1970, et al. (författare)
  • Standardizing radiation oncology data for future modelling of side effects after radiation therapy
  • 2011
  • Ingår i: 1st International Workshop on Managing Interoperability and compleXity in Health Systems, MIXHS'11, Collocated with the 20th ACM International Conference on Information and Knowledge Management, CIKM 2011 Glasgow 28 October 2011 through 28 October 2011. - New York, NY, USA : ACM. - 9781450309547 ; oct 28, s. 67-70
  • Konferensbidrag (refereegranskat)abstract
    • Wider acceptance of data standards in radiation oncology would facilitate pooling of data from different studies. In turn, this would help clinicians and medical physicists to better understand the relationships between radiation treatments and consequent late developing side effects, and to design treatment plans that improve patients' quality of life. In this paper, we describe challenges of collecting and integrating radiation oncology data from medical records and treatment planning systems for the purpose of modelling side effects after radiation therapy. © 2011 ACM.
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48.
  • Pettersson, Niclas, 1974, et al. (författare)
  • A method to estimate composite doses for organs at risk in prostate cancer patients treated with EBRT in combination with HDR BT.
  • 2014
  • Ingår i: Acta oncologica (Stockholm, Sweden). - 1651-226X. ; 53:6, s. 815-821
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. When evaluating late toxicity after combined external beam radiation therapy (EBRT) and high-dose rate brachytherapy (HDR BT) prostate cancer treatments, it is important that the composite dose distribution is taken into account. This can be challenging if organ-at-risk (OAR) dose data are incomplete, i.e. due to a limited ultrasound imaging field-of-view in the HDR BT procedure. This work proposes a method that provides estimates of composite OAR doses for such situations. Material and methods. Original EBRT, simulated HDR BT, and composite dose-volume histograms (DVHs) for 10 pelvic OARs in 30 prostate cancer cases were used for method implementation and evaluation (EBRT: 25 × 2.0 Gy + BT: 2 × 10.0 Gy). The proposed method used information from the EBRT DVH to estimate OAR BT doses (with or without fractionation correction). Coefficients of determination (R(2)) were calculated for linear relationships between several EBRT DVH parameters and a BT DVH parameter of interest. The largest R(2) value decided the relationship that best predicted the BT DVH parameter. The composite dose value was then calculated by adding the EBRT DVH and the estimated BT DVH parameter values and was compared to the reference composite value (in 1200 OAR/patient/parameter cases). Results. The linear relationships had an average R(2) of 0.68 (range 0.42-0.88). Only one ninth of the 1200 estimated composite DVH values differed more than 2 Gy from their reference values. Conclusion. Given a successful implementation, the proposed method only requires original or simulated BT plan data for a subset of patients to estimate composite doses for large study populations in a time-efficient manner. This can assist in evaluating radiation-induced late toxicity in multimodality treatments with limited OAR dose data.
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49.
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50.
  • Thor, Maria, et al. (författare)
  • Radiation Dose to the Penile Structures and Patient-Reported Sexual Dysfunction in Long-Term Prostate Cancer Survivors.
  • 2015
  • Ingår i: The journal of sexual medicine. - : Oxford University Press (OUP). - 1743-6109 .- 1743-6095. ; 12:12
  • Tidskriftsartikel (refereegranskat)abstract
    • The involvement of various penile structures in radiotherapy (RT)-induced sexual dysfunction among prostate cancer survivors remains unclear and domains beyond erectile dysfunction such as orgasm, and pain have typically not been considered. The purpose of this study was to investigate sexual dysfunction post-RT for localized prostate cancer and to examine whether radiation dose to different penile structures can explain these symptoms.
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  • Resultat 41-50 av 57
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Olsson, Caroline, 19 ... (52)
Steineck, Gunnar, 19 ... (19)
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