| 21. |
- Mullins, N., et al.
(författare)
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
- 2021
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 53, s. 817-829
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Tidskriftsartikel (refereegranskat)abstract
- Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies. Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.
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| 22. |
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| 23. |
- Aaron, F. D., et al.
(författare)
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Measurement of isolated photon production in deep-inelastic scattering at HERA
- 2008
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 54:3, s. 371-387
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Tidskriftsartikel (refereegranskat)abstract
- The production of isolated photons in deep-inelastic scattering ep -> e gamma X is measured with the H1 detector at HERA. The measurement is performed in the kinematic range of negative four-momentum transfer squared 4 < Q(2)< 150 GeV2 and a mass of the hadronic system W-X > 50 GeV. The analysis is based on a total integrated luminosity of 227 pb(-1). The production cross section of isolated photons with a transverse energy in the range 3 < E-T(gamma)< 10 GeV and pseudorapidity range -1.2
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| 24. |
- Aaron, F. D., et al.
(författare)
-
Three- and four-jet production at low x at HERA
- 2008
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 54:3, s. 389-409
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Tidskriftsartikel (refereegranskat)abstract
- Three- and four-jet production is measured in deep-inelastic ep scattering at low x and Q(2) with the H1 detector using an integrated luminosity of 44.2 pb(-1). Several phase space regions are selected for the three-jet analysis in order to study the underlying parton dynamics from global topologies to the more restrictive regions of forward jets close to the proton direction. The measurements of cross sections for events with at least three jets are compared to fixed order QCD predictions of O(alpha(2)(s)) and O(alpha(3)(s)) and with Monte Carlo simulation programs where higher order effects are approximated by parton showers. A good overall description is provided by the O(alpha(3)(s)) calculation. Too few events are predicted at the lowest x similar to 10(-4), especially for topologies with two forward jets. This hints to large contributions at low x from initial state radiation of gluons close to the proton direction and unordered in transverse momentum. The Monte Carlo program in which gluon radiation is generated by the colour dipole model gives a good description of both the three- and the four-jet data in absolute normalisation and shape.
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| 25. |
- Adloff, C, et al.
(författare)
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Measurement of D*(+/-) meson production and F-2(c) in deep-inelastic scattering at HERA
- 2002
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 528:3-4, s. 199-214
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Tidskriftsartikel (refereegranskat)abstract
- The inclusive production of D*+/-(2010) mesons in deep-inelastic scattering is studied with the HI detector at HERA. In the kinematic region 1 < Q(2) < 100 GeV2 and 0.05 < y < 0.7 an e(+) p cross section for inclusive D*+/- meson production of 8.50 +/- 0.42(stat.)(-100)(+1.21)(syst.) nb is measured in the visible range p(tD*) > 1.5 GeV and eta(D*) < 1.5. Single and double differential inclusive D*+/- meson cross sections are compared to perturbative QCD calculations in two different evolution schemes, The charm contribution to the proton structure, F-c(2)(x, Q(2)), is determined by extrapolating the visible charm cross section to the full phase space. This contribution is found to rise from about 10% at Q(2) = 1.5 GeV2 to more than 25% at Q(2) = 60 GeV2 corresponding to x values ranging from 5 x 10(-5) to 3 x 10(-3). (C) 2002 Elsevier Science B.V. All rights reserved.
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| 26. |
- Aaron, F. D., et al.
(författare)
-
Study of charm fragmentation into D (* +/-) mesons in deep-inelastic scattering at HERA
- 2009
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 59:3, s. 589-606
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Tidskriftsartikel (refereegranskat)abstract
- The process of charm quark fragmentation is studied using D (* +/-) meson production in deep-inelastic scattering as measured by the H1 detector at HERA. The parameters of fragmentation functions are extracted for QCD models based on leading order matrix elements and DGLAP or CCFM evolution of partons together with string fragmentation and particle decays. Additionally, they are determined for a next-to-leading order QCD calculation in the fixed flavour number scheme using the independent fragmentation of charm quarks to D (* +/-) mesons. Two different regions of phase space are investigated defined by the presence or absence of a jet containing the D (* +/-) meson in the event. The fragmentation parameters extracted for the two phase space regions are found to be different.
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| 27. |
- Adloff, C, et al.
(författare)
-
Energy flow and rapidity gaps between jets in photoproduction at HERA
- 2002
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 24:4, s. 517-527
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Tidskriftsartikel (refereegranskat)abstract
- Dijet events in photon-proton collisions in which there is a large pseudorapidity separation, Deltaeta > 2.5 between the two highest E-T jets are studied with the H1 detector at HERA. The inclusive dijet cross sections are measured as functions of the longitudinal momentum fractions of the proton and photon which participate in the production of the jets, x(p)(jets) and x(gamma)(jets) respectively, Deltaeta, the pseudorapidity P separation between the two highest E-T jets, and E-T(gap), the total summed transverse energy between the jets. Rapidity gap events are defined as events in which E-T(gap) is less than E-T(cut), for E-T(cut) varied between jets 0.5 and 2.0 GeV. The fraction of dijet events with a rapidity gap is measured differentially in Deltaeta, x(p)(jets) and x(gamma)(jets). An excess of events with rapidity gaps at low values of E-T(cut) is observed above the expectation from standard photoproduction processes. This excess can be explained by the exchange of a strongly interacting colour singlet object between the jets.
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| 28. |
- Adloff, C, et al.
(författare)
-
Measurement of dijet electroproduction at small jet separation
- 2002
-
Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 24:1, s. 33-41
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Tidskriftsartikel (refereegranskat)abstract
- Deep-inelastic scattering data in the range 150 < Q(2) < 35000 GeV2 are used to investigate the minimum jet separation necessary to allow accurate description of the rate of dijet production using next-to-leading order perturbative QCD calculations. The required jet separation is found to be small, allowing about 1/3 of DIS data to be classified as dijet, as opposed to approximately 1/10 with more typical jet analyses. A number of precision measurements made using this dijet sample are well described by the calculations. The data are also described by the combination of leading order matrix elements and parton showers, as implemented in the QCD based Monte Carlo model RAPGAP.
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| 29. |
- Adloff, C, et al.
(författare)
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Search for excited neutrinos at HERA
- 2002
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 525:1-2, s. 9-16
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for excited neutrinos using e(-) p data taken by the H1 experiment at HERA at a center-of-mass energy of 318 GeV with an integrated luminosity of 15 pb(-1). No evidence for excited neutrino production is found. Mass dependent exclusion limits are determined for the ratio of the coupling to the compositeness scale, f/Lambda, independently of the relative couplings to the SU(2) and U(1) gauge bosons. These limits extend the excluded region to higher masses than has been possible in previous searches at other colliders.
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| 30. |
- Adloff, C, et al.
(författare)
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Search for odderon-induced contributions to exclusive pi(0) photoproduction at HERA
- 2002
-
Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 544:1-2, s. 35-43
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Tidskriftsartikel (refereegranskat)abstract
- A search for contributions to the reaction ep --> epi(0)N* from photon-odderon fusion in the photoproduction regime at HERA is reported, at an average photon-proton centre-of-mass energy = 215 GeV. The measurement proceeds via detection of the pi(0) decay photons, a leading neutron from the N* decay, and the scattered electron. No pi(0) signal is observed and an upper limit on the cross section for the photon-odderon fusion process of sigma(gammap --> pi(0)N*) < 49 nb at the 95% confidence level is derived, integrated over the experimentally accessible range of the squared four-momentum transfer at the nucleon vertex 0.02 < < 0.3 GeV2. This excludes a recent prediction from a calculation based on a non-perturbative QCD model of a photon-odderon fusion cross section above 200 nb. (C) 2002 Elsevier Science B.V. All rights reserved.
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