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Search: WFRF:(Oreland L.)

  • Result 41-50 of 158
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  • DeYoung, Colin G., et al. (author)
  • Variation in the catechol-O-methyltransferase Val(158)Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
  • 2010
  • In: Psychiatric Genetics. - 0955-8829 .- 1473-5873. ; 20:1, s. 20-24
  • Journal article (peer-reviewed)abstract
    • Objective Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results The Val allele of the Val(158)Met polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion The Val(158)Met polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population. Psychiatr Genet 20:20-24 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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  • Ekblom, J, et al. (author)
  • Elevated activity of semicarbazide-sensitive amine oxidase in blood from patients with skeletal metastases of prostate cancer.
  • 1999
  • In: Clinical science (London, England : 1979). - 0143-5221. ; 97:1, s. 111-5
  • Journal article (peer-reviewed)abstract
    • The semicarbazide-sensitive amine oxidases constitute a group of copper-containing enzymes whose physiological function is unclear. The enzymes are present in various tissues, including blood plasma. At present, the source of the plasma enzyme in humans is not known. Results of a recent study suggested that semicarbazide-sensitive amine oxidase is expressed in the skeleton, e.g. in the spine. Using an indirect autoradiographic method in mice, we provide evidence that semicarbazide-sensitive amine oxidase is present in high abundance in bone tissue. Specific activities of semicarbazide-sensitive amine oxidase were estimated in blood samples from subjects with femoral bone fractures. Moreover, enzyme activities were also measured in patients suffering from prostate cancer with skeletal metastases. The level of specific semicarbazide-sensitive amine oxidase activity in serum was significantly elevated in patients with skeletal metastases compared with both healthy controls and patients having prostate cancer without signs of skeletal metastases. Based on the results of the present study, we propose that semicarbazide-sensitive amine oxidase in blood plasma may originate, at least in part, from the skeleton.
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  • Result 41-50 of 158
Type of publication
journal article (139)
conference paper (10)
book chapter (6)
other publication (1)
doctoral thesis (1)
review (1)
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Type of content
peer-reviewed (137)
other academic/artistic (21)
Author/Editor
Oreland, L (135)
Garpenstrand, H (32)
Ekblom, J (30)
Harro, J (28)
Hallman, J (22)
Oreland, Lars (21)
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Damberg, M (17)
af Klinteberg, B. (12)
Leppert, Jerzy (11)
Sjöberg, Rickard L (11)
af Klinteberg, Britt (10)
Nilsson, Kent W. (10)
Prince, J (9)
Eller, M (8)
Grigorenko, Elena L. (8)
Forslund, K (7)
Koposov, Roman A. (7)
Lindström, Leif (6)
Rylander, G (6)
Öhrvik, John (5)
Lofberg, C (5)
Ruchkin, Vladislav V ... (5)
Jonsson, EG (4)
von Knorring, L. (4)
Sedvall, GC (4)
Gottfries, C G (4)
Asberg, M (4)
Norton, N (4)
Yassin, M (4)
Gomes-Trolin, C (4)
Rinken, A (4)
Getchell, Marya (4)
Yrigollen, Carolyn M ... (4)
Haeffel, Gerald J. (4)
Arai, Y. (3)
Fredrikson, Mats (3)
LIDBERG, L (3)
Hokfelt, T (3)
Alm, Per-Olof (3)
Gustavsson, P (3)
Leppert, J (3)
Owen, MJ (3)
Tadano, T. (3)
Prince, JA (3)
Damberg, Mattias (3)
Wargelius, Hanna-Lin ... (3)
Mattila-Evenden, M (3)
Allik, J (3)
DeYoung, Colin G. (3)
Pakstis, Andrew J. (3)
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University
Uppsala University (132)
Karolinska Institutet (30)
Stockholm University (14)
Umeå University (9)
Mälardalen University (9)
University of Gothenburg (2)
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Lund University (1)
Mid Sweden University (1)
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Language
English (152)
Undefined language (3)
Swedish (2)
Norwegian (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (19)
Social Sciences (13)
Natural sciences (1)

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