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21.	Hall, T. R., et al. (author) Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes 2006 In: Clinical and Experimental Immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 146:1, s. 41531-41531 Journal article (peer-reviewed)abstract Autoantibodies to insulin (IAA) are one of the first markers of the autoimmune process leading to type 1 diabetes (T1D). While other autoantibodies in T1D have been studied extensively, relatively little is known about IAA and their binding specificities, especially after insulin treatment is initiated. We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment differ in their epitope specificities from IAA. We analysed insulin antibody binding specificities in longitudinal samples of T1D patients (n = 49). Samples were taken at clinical diagnosis of disease and after insulin treatment was initiated. The epitope specificities were analysed using recombinant Fab (rFab) derived from insulin-specific monoclonal antibodies AE9D6 and CG7C7. Binding of radiolabelled insulin by samples taken at onset of the disease was significantly reduced in the presence of rFab CG7C7 and AE9D6. rFab AE9D6 competed sera binding to insulin significantly better than rFab CG7C7 (P = 0.02). Binding to the AE9D6-defined epitope in the initial sample was correlated inversely with age at onset (P = 0.005). The binding to the AE9D6-defined epitope increased significantly (P < 0.0001) after 3 months of insulin treatment. Binding to the CG7C7-defined epitope did not change during the analysed period of 12 months. We conclude that epitopes recognized by insulin binding antibodies can be identified using monoclonal insulin-specific rFab as competitors. Using this approach we observed that insulin treatment is accompanied by a change in epitope specificities in the emerging IA.
22.	Hammerle, LP, et al. (author) Glutamic acid decarboxylase (GAD) recognition by autoantibodies from GAD antibody-positive phenotypes. 2000 In: DIABETOLOGIA. - 0012-186X. ; 43, s. A104-A104 Conference paper (other academic/artistic)
23.	Hampe, CS, et al. (author) Fab of a human monoclonal antibody specifically inhibits GAD65Ab in Type 1 diabetes. 2003 In: DIABETOLOGIA. - 0012-186X. ; 46, s. A15-A15 Conference paper (other academic/artistic)
24.	Hampe, CS, et al. (author) GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoinimune diabetes 2002 In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 25:8, s. 1481-1482 Journal article (other academic/artistic)
25.	Hampe, CS, et al. (author) Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes 1999 In: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. - : Georg Thieme Verlag KG. - 0018-5043. ; 31:10, s. 553-557 Journal article (peer-reviewed)
26.	Hampe, C, et al. (author) Insulin autoantibodies and antibodies in type 1 diabetes. 2006 In: CLINICAL IMMUNOLOGY. - : Elsevier BV. - 1521-6616. ; 119, s. S172-S172 Conference paper (other academic/artistic)
27.	Hampe, CS, et al. (author) Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes 2000 In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 85:12, s. 4671-4679 Journal article (peer-reviewed)
28.	Hampe, CS, et al. (author) Species-specific autoantibodies in type 1 diabetes 1999 In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 84:2, s. 643-648 Journal article (peer-reviewed)
29.	Hampe, CS, et al. (author) Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset 2002 In: Journal of autoimmunity. - : Elsevier BV. - 0896-8411. ; 18:1, s. 49-53 Journal article (peer-reviewed)
30.	Hamrin, J, et al. (author) EFFECTIVENESS OF A MONO-VALENT ADJUVANTED VACCINE (PANDEMRIX) FOR THE PREVENTION OF HOSPITALISATION FOR INFLUENZA A (H1N1)V INFECTION IN CHILDREN 2010 In: ACTA PAEDIATRICA. - 0803-5253. ; 99, s. 85-85 Conference paper (other academic/artistic)

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Type of publication: journal article (46); conference paper (17)

Type of content: peer-reviewed (44); other academic/artistic (19)

Author/Editor: LERNMARK, A (12); Ortqvist, A (12); Persson, B (11); Kockum, I. (8); Lernmark, Åke (8); Henriques-Normark, B (6); show more...; Ludvigsson, Johnny (6); Bang, P (5); Carlsson, Annelie (5); Stephansson, O (4); Torn, C (4); Landin-Olsson, M (4); Marcus, C (4); Landin-Olsson, Mona (3); Palmer, J (3); Jorup, C (2); Sunyer, J (2); Nilsson, A (2); Almqvist, C (2); Ziegler, M. (2); Kere, J (2); Johansson, C. (2); Melen, E (2); Merid, SK (2); IVARSSON, SA (2); CARLSSON, A (2); FALORNI, A (2); Nord, E (2); Torres, A (2); Ivarsson, Sten (2); Ivarsson, S A (2); Koppelman, GH (2); Bustamante, M (2); Blennow, M. (2); Lahti, J (2); Kajantie, E. (2); Raikkonen, K. (2); Snieder, H. (2); Ludvigsson, J (2); Grahnquist, L (2); Geraghty, Daniel E. (2); Gao, L (2); Marcus, Claude (2); Normark, BH (2); Lindstrand, A (2); Bergstrom, A (2); Kockum, Ingrid (2); Holloway, JW (2); Felix, JF (2); Jaddoe, VWV (2); show less...

University: Karolinska Institutet (60); Lund University (11); Linköping University (8); University of Gothenburg (4); Uppsala University (3)

Language: English (63)

Research subject (UKÄ/SCB): Medical and Health Sciences (13)

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